Výsledky vyhledávání - "Raphaël Bergès"

Akademický článek

Anti-migratory effect of vinflunine in endothelial and glioblastoma cells is associated with changes in EB1 C-terminal detyrosinated/tyrosinated status.

Autor: Amandine Rovini, Géraldine Gauthier, Raphaël Bergès, Anna Kruczynski, Diane Braguer, Stéphane Honoré

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65694 (2013)

We previously showed that vinflunine, a microtubule-targeting drug of the Vinca-alkaloid family exerted its anti-angiogenic/anti-migratory activities through an increase in microtubule dynamics and an inhibition of microtubule targeting to adhesion s

Externí odkaz: https://doaj.org/article/10aa21802b7c4e93ad22b7b54eebd9c8

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Data from The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like Cells

Autor: Diane Braguer, Heidi A. Lane, Felix Bachmann, Dominique Figarella-Branger, Marie-Anne Estève, Stéphane Honoré, Aurélie Tchoghandjian, Raphaël Bergès

Glioblastoma patients have limited treatment options. Cancer stem-like cells (CSLC) contribute to glioblastoma invasiveness and repopulation; hence, they represent promising targets for novel therapies. BAL101553 is a prodrug of BAL27862, a novel mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8597a7d9a92e091a8aa184b25993cdaf
https://doi.org/10.1158/1535-7163.c.6538392.v1

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Supplementary Figure 1 from The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like Cells

Autor: Diane Braguer, Heidi A. Lane, Felix Bachmann, Dominique Figarella-Branger, Marie-Anne Estève, Stéphane Honoré, Aurélie Tchoghandjian, Raphaël Bergès

Chemical structure of BAL27862 and BAL101553

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b56f9a196a1212cd3d155afdf23645
https://doi.org/10.1158/1535-7163.22506411

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Supplementary data from The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like Cells

Autor: Diane Braguer, Heidi A. Lane, Felix Bachmann, Dominique Figarella-Branger, Marie-Anne Estève, Stéphane Honoré, Aurélie Tchoghandjian, Raphaël Bergès

Materials and methods: EB1 Western blot analysis GBM stem cells were lysed (lysis buffer: Tris 50 mM pH 8.0, NaCl 250 mM, Triton-X100 1%, SDS 0.1% with a cocktail of proteases and phosphatases inhibitors added freshly (all from Sigma-Aldrich). Thirty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbc668269fdcdfe4c080a1d5452ca34
https://doi.org/10.1158/1535-7163.22506402

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Supplementary Table 1 from The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like Cells

Autor: Diane Braguer, Heidi A. Lane, Felix Bachmann, Dominique Figarella-Branger, Marie-Anne Estève, Stéphane Honoré, Aurélie Tchoghandjian, Raphaël Bergès

Sequences of primers used in RT-qPCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e9ec4dee2895b21f6c694662f37b1b
https://doi.org/10.1158/1535-7163.22506405.v1

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Akademický článek

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergismsResearch in context

Publikováno v: EBioMedicine, Vol 95, Iss , Pp 104752- (2023)

Summary: Background: Pharmacological synergisms are an attractive anticancer strategy. However, with more than 5000 approved-drugs and compounds in clinical development, identifying synergistic treatments represents a major challenge. Methods: High-t

Externí odkaz: https://doaj.org/article/4e5974d9a61641e8a0393d2342009fa9

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Akademický článek

Bcl-2—Enhanced Efficacy of Microtubule-Targeting Chemotherapy through Bim Overexpression: Implications for Cancer Treatment

Autor: Amandine Savry, Manon Carre, Raphael Berges, Amandine Rovini, Isabelle Pobel, Christine Chacon, Diane Braguer, Véronique Bourgarel-Rey

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 1, Pp 49-60 (2013)

Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2– overexpressing lung and breast

Externí odkaz: https://doaj.org/article/6afa7a48fb074511bf561ba859ff26c3

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Akademický článek

Structure-function analysis of the glioma targeting NFL-TBS.40-63 peptide corresponding to the tubulin-binding site on the light neurofilament subunit.

Autor: Raphael Berges, Julien Balzeau, Masayuki Takahashi, Chantal Prevost, Joel Eyer

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49436 (2012)

We previously reported that a 24 amino acid peptide (NFL-TBS.40-63) corresponding to the tubulin-binding site located on the light neurofilament subunit, selectively enters in glioblastoma cells where it disrupts their microtubule network and inhibit

Externí odkaz: https://doaj.org/article/26ab9759462b464bae3cd08d80586852

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