Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Raphaël B. Di Roberto"'
Autor:
Darya Palianina, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice Schlatter, Sai T. Reddy, Nina Khanna
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 147-160 (2023)
Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients. Determining the fate of T cells following patient infusion hing
Externí odkaz:
https://doaj.org/article/fea1c089820d4784ba1fddc771bbef48
Autor:
Rocío Castellanos-Rueda, Raphaël B. Di Roberto, Florian Bieberich, Fabrice S. Schlatter, Darya Palianina, Oanh T. P. Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T. Reddy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Chimeric antigen receptors (CAR) are a promising option for cell-based immunotherapy for cancer and other immune diseases. Here the authors develop speedingCARs, an integrated CAR design and screening platform based on modular signaling domain shuffl
Externí odkaz:
https://doaj.org/article/425fba4bd9014be0893eb9301c9410e9
Autor:
Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Sai T. Reddy, Bruno E. Correia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches ac
Externí odkaz:
https://doaj.org/article/abf45e9fa38440d9ad04bb724c9f71ce
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions wi
Externí odkaz:
https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
Autor:
Darya Palianina, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice Schlatter, Sai T. Reddy, Nina Khanna
Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients. Determining the fate of T cells following patient infusion hing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b457c7c7df433e661f6de943a9f3b0
https://doi.org/10.1101/2022.10.31.514542
https://doi.org/10.1101/2022.10.31.514542
Autor:
Roy A. Ehling, Cédric R. Weber, Derek M. Mason, Simon Friedensohn, Bastian Wagner, Florian Bieberich, Edo Kapetanovic, Rodrigo Vazquez-Lombardi, Raphaël B. Di Roberto, Kai-Lin Hong, Camille Wagner, Michele Pataia, Max D. Overath, Daniel J. Sheward, Ben Murrell, Alexander Yermanos, Andreas P. Cuny, Miodrag Savic, Fabian Rudolf, Sai T. Reddy
Publikováno v:
Cell Reports
Cell Reports, 38 (3)
Cell Reports, 38 (3)
Characterization of COVID-19 antibodies has largely focused on memory B cells; however, it is the antibody-secreting plasma cells that are directly responsible for the production of serum antibodies, which play a critical role in resolving SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9780eee78187f0a54828d4403ac33a2e
https://pubmed.ncbi.nlm.nih.gov/34998467
https://pubmed.ncbi.nlm.nih.gov/34998467
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
G protein-coupled receptors (GPCRs) must discriminate between hundreds of related signal molecules. In order to better understand how GPCR specificity can arise from a common promiscuous ancestor, we used laboratory evolution to invert the specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8b358e4612abc34b5faeb10494074
http://link.springer.com/article/10.1038/s41598-017-16332-2
http://link.springer.com/article/10.1038/s41598-017-16332-2
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1596
The ability to sense and process cues about changing environments is fundamental to life. Cells have evolved elaborate signaling pathways in order to respond to both internal and external stimuli appropriately. These pathways combine protein receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aeb60b943698c160a6758a8581de4424
https://pubmed.ncbi.nlm.nih.gov/28293896
https://pubmed.ncbi.nlm.nih.gov/28293896
Publikováno v:
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 322:65-72
In a seminal paper entitled "Evolution and Tinkering," Francois Jacob affirmed that: "Novelties come from previously unseen association of old material. To create is to recombine" [Jacob F. (1977) Science 196:1161-1166]. In the 35 years that have pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf83ba4694eb68bf7b6f4122c4b7756
https://doi.org/10.1002/jez.b.22551
https://doi.org/10.1002/jez.b.22551
Publikováno v:
Di Roberto, R B, Chang, B, Trusina, A & Peisajovich, S G 2016, ' Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions ', Nature Communications, vol. 7, 12344 . https://doi.org/10.1038/ncomms12344
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
All cellular functions depend on the concerted action of multiple proteins organized in complex networks. To understand how selection acts on protein networks, we used the yeast mating receptor Ste2, a pheromone-activated G protein-coupled receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cca20da989756a48556f5ad793e17c
https://curis.ku.dk/ws/files/168060899/ncomms12344.pdf
https://curis.ku.dk/ws/files/168060899/ncomms12344.pdf