EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Autor: Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity o

Externí odkaz: https://doaj.org/article/840ba9a727064edb97ff673ade34b357

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

Autor: Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z. Shahidian, Ivaylo Vassilev, Nicolas Servant, Damarys Loew, Eric Pasmant, Sophie Postel-Vinay, Michel Wassef, Raphaël Margueron

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silenci

Externí odkaz: https://doaj.org/article/92338fdb37b04b3b97a5b2deb5e4d404

Rare germline heterozygous missense variants in BRCA1-associated protein 1, BAP1, cause a syndromic neurodevelopmental disorder

Autor: Sébastien Küry, Frédéric Ebstein, Alice Mollé, Thomas Besnard, Ming-Kang Lee, Virginie Vignard, Tiphaine Hery, Mathilde Nizon, Grazia M.S. Mancini, Jacques C. Giltay, Benjamin Cogné, Kirsty McWalter, Wallid Deb, Hagar Mor-Shaked, Hong Li, Rhonda E. Schnur, Ingrid M. Wentzensen, Anne-Sophie Denommé-Pichon, Cynthia Fourgeux, Frans W. Verheijen, Eva Faurie, Rachel Schot, Cathy A. Stevens, Daphne J. Smits, Eileen Barr, Ruth Sheffer, Jonathan A. Bernstein, Chandler L. Stimach, Eliana Kovitch, Vandana Shashi, Kelly Schoch, Whitney Smith, Richard H. van Jaarsveld, Anna C.E. Hurst, Kirstin Smith, Evan H. Baugh, Suzanne G. Bohm, Emílie Vyhnálková, Lukáš Ryba, Capucine Delnatte, Juanita Neira, Dominique Bonneau, Annick Toutain, Jill A. Rosenfeld, Séverine Audebert-Bellanger, Brigitte Gilbert-Dussardier, Sylvie Odent, Frédéric Laumonnier, Seth I. Berger, Ann C.M. Smith, Franck Bourdeaut, Marc-Henri Stern, Richard Redon, Elke Krüger, Raphaël Margueron, Stéphane Bézieau, Jeremie Poschmann, Bertrand Isidor

Publikováno v: American Journal of Human Genetics
American Journal of Human Genetics, 2022, 109 (2), pp.361-372. ⟨10.1016/j.ajhg.2021.12.011⟩
American Journal of Human Genetics, 109(2), 361-372. Cell Press
Am J Hum Genet

International audience; Nuclear deubiquitinase BAP1 (BRCA1-associated protein 1) is a core component of multiprotein complexes that promote transcription by reversing the ubiquitination of histone 2A (H2A). BAP1 is a tumor suppressor whose germline l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30291939060519e6db8780d53aed2bef
https://doi.org/10.1016/j.ajhg.2021.12.011

Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Autor: Sophie Postel-Vinay, Christopher J. Lord, Jessica A. Downs, Eric Deutsch, Jean-Charles Soria, Geneviève Almouzni, Jyoti S. Choudhary, Raphaël Margueron, Stephen J. Pettitt, Christophe Massard, Elaine Del Nery, Asha Konde, Clémence Astier, Asuka Kawai-Kawachi, Clémence Hénon, Samuel Jouny, Theodoros I. Roumeliotis, Suzanna R. Hopkins, Carine Ngo, Andrew Lamb, Cornelia Meisenberg, Marlène Garrido, Nicolas Dorvault, Ilirjana Bajrami, Léo Colmet-Daage, Thomas Eychenne, Daphné Morel, Roman M. Chabanon

Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91bf09169c717b744a215d84d8cf834
https://doi.org/10.1158/0008-5472.22429903.v1

Data from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Autor: Sophie Postel-Vinay, Christopher J. Lord, Jessica A. Downs, Eric Deutsch, Jean-Charles Soria, Geneviève Almouzni, Jyoti S. Choudhary, Raphaël Margueron, Stephen J. Pettitt, Christophe Massard, Elaine Del Nery, Asha Konde, Clémence Astier, Asuka Kawai-Kawachi, Clémence Hénon, Samuel Jouny, Theodoros I. Roumeliotis, Suzanna R. Hopkins, Carine Ngo, Andrew Lamb, Cornelia Meisenberg, Marlène Garrido, Nicolas Dorvault, Ilirjana Bajrami, Léo Colmet-Daage, Thomas Eychenne, Daphné Morel, Roman M. Chabanon

Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell carcinomas (ccRCC). To identify novel therapeutic approaches to targeting PBRM1-defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6091fc71a7c522b42ba404c337832524
https://doi.org/10.1158/0008-5472.c.6513481.v1