Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Raoxian Bai"'
Autor:
Ruo Wu, Bing Bai, Feng Li, Raoxian Bai, Yan Zhuo, Zhengna Zhu, Rongfang Jia, Shangang Li, Yongchang Chen, Xiaoping Lan
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionPolycystic kidney disease (PKD) is a common autosomal dominant or recessive genetic disease, often accompanied by polycystic liver disease (PLD). Many cases of PKD in animals have been reported. However, little is known about the genes th
Externí odkaz:
https://doaj.org/article/4fb52562663745f4b3aa19ded96e5ebb
Autor:
Shuaiwei Ren, Mei Huang, Raoxian Bai, Lijiao Chen, Jiao Yang, Junyu Zhang, Wenting Guo, Weizhi Ji, Yongchang Chen
Publikováno v:
Research, Vol 6 (2023)
Splice-switching antisense oligonucleotides (ASOs) and engineered U7 small nuclear ribonucleoprotein (U7 Sm OPT) are the most commonly used methods for exon skipping. However, challenges remain, such as limited organ delivery and repeated dosing for
Externí odkaz:
https://doaj.org/article/3eb6bbb0d25c42debfbc3283139a7e1e
Autor:
Shangang Li, Weizhi Ji, Bin Shen, Yongchang Chen, Ting Zhang, Yu Hou, Lijiao Chen, Ruo Wu, Yuyu Niu, Puhao Xiao, Raoxian Bai
Publikováno v:
Science Bulletin. 66:2061-2064
Autor:
Liyun Yang, Lijiao Chen, Yang Zheng, Li Deng, Raoxian Bai, Ting Zhang, Zhengbo Wang, Shangang Li
Background The CRISPR/Cas9 system can induce off-target effects in programmed gene editing, but there have been few reports on cleavage detection and characterization in early embryos. To study these events, sgRNAs with different off-target rates wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af537715c4fe837e61fb93039dfc29d
https://doi.org/10.21203/rs.3.rs-1725345/v1
https://doi.org/10.21203/rs.3.rs-1725345/v1
Autor:
Puhao Xiao, Yuyu Niu, Raoxian Bai, Shuang Wang, Qin Zhou, Weizhi Ji, Yongchang Chen, Shuaiwei Ren, Zhigang Zhou, Yin Zhou
Publikováno v:
Journal of Biological Chemistry. 293:11654-11658
CRISPR/Cas9 is now widely used in biomedical research and has great potential for clinical applications. However, the safety and efficacy of this gene-editing technique are significant issues. Recent reports on mouse models and human cells have raise
Autor:
Lichuan Yang, Shuang Wang, Weizhi Ji, Yongchang Chen, Yuyu Niu, Yuanye Ma, Shuaiwei Ren, Raoxian Bai
Publikováno v:
Cell Cycle. 17:1146-1153
The tumor suppressor p53 is a key regulator of cell apoptosis and cell cycle arrest. Recent studies show that the delicate balance of p53 expression is important for neural tube defects, neuronal degeneration, embryonic lethality, as well as differen
Autor:
Weizhi Ji, Shuaiwei Ren, Yin Zhou, Nannan Gong, Ting Zhang, Ruo Wu, Bin Shen, Raoxian Bai, Puhao Xiao, Yuyu Niu, Yongchang Chen, Jie Liu, Zhigang Zhou, Shangang Li, Yan Zhuo
The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4c280e1f192860c24dc49dbd8e6a9e
https://doi.org/10.1101/588913
https://doi.org/10.1101/588913
Autor:
Chenyang Si, Shuang Wang, Rui Geng, Shaoyong Huang, Yongchang Chen, Xinhua Bao, Hailiang Liu, Zhenzhen Chen, Yu Kang, Aibin Liang, Raoxian Bai, Xiaojing Liu, Kunhua Wu, Junbang Wang, Yuanye Ma, Xiaoying Chen, Juehua Yu, Jing He, Weizhi Ji, Kunshan Zhang, Yingzhou Hu, Dinggang Shen, Siguang Li, Jiaojian Wang, Xintian Hu, Yuyu Niu, Yong Jiang, Jie Liu, Yuping Luo, Tianzi Jiang, Fuxing Li, Jingkuan Wei, Qingping Zhang, Dongdong Qin, Yi Lu, Gang Li, Yi Eve Sun
Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b29778190f8392f225296302d514b1
Autor:
Shuang Wang1,2, Shuaiwei Ren1,2, Raoxian Bai1,2, Puhao Xiao1,2, Qin Zhou1,2, Yin Zhou1,2, Zhigang Zhou1,2, Yuyu Niu1,2, Weizhi Ji1,2 wji@lpbr.cn, Yongchang Chen1,2 chenyc@lpbr.cn
Publikováno v:
Journal of Biological Chemistry. 7/27/2018, Vol. 293 Issue 30, p11654-11658. 5p.