Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Raoul Kuiper"'
Publikováno v:
Viruses, Vol 15, Iss 12, p 2450 (2023)
Salmonid alphavirus strain 3 is responsible for outbreaks of pancreas disease in salmon and rainbow trout in Norway. Although the extensive amount of research on SAV3 focused mainly on the heart and pancreas (of clinical importance), tropism and path
Externí odkaz:
https://doaj.org/article/fffcb9338c0546b2a7afbbe046f74eda
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0285242 (2023)
Deficiency in thymidine kinase 2 (TK2) causes mitochondrial DNA depletion. Liver mitochondria are severely affected in Tk2 complete knockout models and have been suggested to play a role in the pathogenesis of the Tk2 knockout phenotype, characterize
Externí odkaz:
https://doaj.org/article/6876bf47e36e442e95ca1b6b4130f731
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270418 (2022)
Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO). The mice showed dilated hearts and markedly reduced
Externí odkaz:
https://doaj.org/article/bc4eac1f3f7c434ebabaf5da28e4397b
Autor:
Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regu
Externí odkaz:
https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Claudin-low breast cancer is a molecular subtype associated with poor prognosis and without targeted treatment options. The claudin-low subtype is defined by certain biological characteristics, some of which may be clinically acti
Externí odkaz:
https://doaj.org/article/3b7657205c914ee5a07ce3794a02b748
Autor:
Ning Liang, Anastasius Damdimopoulos, Saioa Goñi, Zhiqiang Huang, Lise-Lotte Vedin, Tomas Jakobsson, Marco Giudici, Osman Ahmed, Matteo Pedrelli, Serena Barilla, Fawaz Alzaid, Arturo Mendoza, Tarja Schröder, Raoul Kuiper, Paolo Parini, Anthony Hollenberg, Philippe Lefebvre, Sven Francque, Luc Van Gaal, Bart Staels, Nicolas Venteclef, Eckardt Treuter, Rongrong Fan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.
Externí odkaz:
https://doaj.org/article/90508a91d07f4ebf99f099ffd68ebc8f
Autor:
Jens Henrik Norum, Ellen Skarpen, Andreas Brech, Raoul Kuiper, Jo Waaler, Stefan Krauss, Therese Sørlie
Publikováno v:
Biological Research, Vol 51, Iss 1, Pp 1-13 (2018)
Abstract Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 a
Externí odkaz:
https://doaj.org/article/c602d1f4a91649c89ddb1447f21d1b87
Autor:
Ioannis Zerdes, Vaia Karafousia, Artur Mezheyeuski, Maria Stogiannitsi, Raoul Kuiper, Pablo Moreno Ruiz, George Rassidakis, Jonas Bergh, Thomas Hatschek, Theodoros Foukakis, Alexios Matikas
Publikováno v:
Cancers, Vol 13, Iss 18, p 4655 (2021)
We aimed to assess if the discrepant prognostic information between Programmed Death Ligand 1 (PD-L1) protein versus mRNA expression in early breast cancer (BC) could be attributed to heterogeneity in its expression. PD-L1 protein and mRNA expression
Externí odkaz:
https://doaj.org/article/ef6772e8b7224629a7c4efa27498c188
Autor:
John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E Kennedy, Nicholas E Gott, Louise A Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205775 (2018)
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alope
Externí odkaz:
https://doaj.org/article/54573e0a95f049668de7342ab1349d2c
Autor:
Roel Hermsen, Pim Toonen, Ewart Kuijk, Sameh A Youssef, Raoul Kuiper, Sebastiaan van Heesch, Alain de Bruin, Edwin Cuppen, Marieke Simonis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122066 (2015)
Tumorigenesis is often associated with loss of tumor suppressor genes (such as TP53), genomic instability and telomere lengthening. Previously, we generated and characterized a rat p53 knockout model in which the homozygous rats predominantly develop
Externí odkaz:
https://doaj.org/article/cd1fdc2f53104ad8b71c5f5850273ebb