Výsledky vyhledávání - "Raouf El Cheikh"

Akademický článek

Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

Autor: Hagen B. Huttner, Olaf Bergmann, Mehran Salehpour, Raouf El Cheikh, Makoto Nakamura, Angelo Tortora, Paula Heinke, Roland Coras, Elisabet Englund, Ilker Y. Eyüpoglu, Joji B. Kuramatsu, Sebastian S. Roeder, Stephan P. Kloska, Iris Muehlen, Arnd Doerfler, Stefan Schwab, Göran Possnert, Samuel Bernard, Jonas Frisén

Publikováno v: EBioMedicine, Vol 27, Iss C, Pp 176-181 (2018)

It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum,

Externí odkaz: https://doaj.org/article/5d03953551da44fba56402ba139644f6

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Data from Implication of the Autologous Immune System in BCR–ABL Transcript Variations in Chronic Myelogenous Leukemia Patients Treated with Imatinib

Autor: Doron Levy, Franck E. Nicolini, Hélène Labussière-Wallet, Jérémy Ruby, Samuel Bernard, Raouf El Cheikh, Thomas Lepoutre, Geoffrey D. Clapp

Imatinib and other tyrosine kinase inhibitors (TKI) have improved treatment of chronic myelogenous leukemia (CML); however, most patients are not cured. Deeper mechanistic understanding may improve TKI combination therapies to better control the resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c27bf527d0a2c1957063530e927f79
https://doi.org/10.1158/0008-5472.c.6507360

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PK/PD modeling analysis for dosing regimen selection of isatuximab as single agent and in combination therapy in patients with multiple myeloma

Autor: Marie-Laure Risse, Raouf El-Cheikh, Christine Veyrat-Follet, Laurent Nguyen, Jean-Baptiste Fau, Kimiko Koiwai, Hoai-Thu Thai, Claire Brillac, Dorothée Semiond, Helgi van de Velde

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 928-940 (2021)
CPT: Pharmacometrics & Systems Pharmacology

This analysis describes the pharmacokinetic/pharmacodynamic (PK/PD) modeling framework that supported selection of the isatuximab (anti‐CD38 monoclonal antibody) dosing regimen alongside its early clinical development in patients with relapsed/refr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a997ea428917d8421071c0e38a2a3e3
https://doaj.org/article/af2cc48054174339a0403cbbf840ec73

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Drug‐Disease Interaction and Time‐Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients

Autor: Frank Campana, Claire Brillac, Laurent Nguyen, Dorothée Semiond, Jean-Baptiste Fau, Nathalie Mace, Kimiko Koiwai, Raouf El-Cheikh

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 11, Pp 649-658 (2020)
CPT: Pharmacometrics & Systems Pharmacology

Isatuximab, a monoclonal antibody (mAb) of immunoglobulin G (IgG) isotype, specifically targets the cluster of differentiation 38 antigen overexpressed in malignant plasma cells. Isatuximab is used to treat multiple myeloma (MM), characterized by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b98ba770f1c9d065062922141573327
https://doaj.org/article/0b977e74df2045d28990c4247039121a

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A multiscale modelling approach for the regulation of the cell cycle by the circadian clock

Autor: Samuel Bernard, Nader El Khatib, Raouf El Cheikh

Publikováno v: Journal of Theoretical Biology
Journal of Theoretical Biology, Elsevier, 2017, 426, pp.117-125. ⟨10.1016/j.jtbi.2017.05.021⟩
Journal of Theoretical Biology, 2017, 426, pp.117-125. ⟨10.1016/j.jtbi.2017.05.021⟩

International audience; We present a multiscale mathematical model for the regulation of the cell cycle by the circadian clock. Biologically, the model describes the proliferation of a population of heterogeneous cells connected to each other. The mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c97112a259c76011f73974ea20153cb
https://doi.org/10.1016/j.jtbi.2017.05.021

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Validation of Neutrophil Count as An Algorithm-Based Predictive Factor of Progression-Free Survival in Patients with Metastatic Soft Tissue Sarcomas Treated with Trabectedin

Autor: Sébastien Salas, Maeva Andriantsoa, Dominique Barbolosi, Alexandre de Nonneville, Florence Duffaud, François Bertucci, Raouf El-Cheikh

Publikováno v: Contemporary Southeast Asia
Contemporary Southeast Asia, 2019, 11 (3), pp.432. ⟨10.3390/cancers11030432⟩
Cancers
Cancers, MDPI, 2019, 11 (3), pp.432. ⟨10.3390/cancers11030432⟩
Cancers, Vol 11, Iss 3, p 432 (2019)
Contemporary Southeast Asia, Taylor & Francis, 2019, 11 (3), pp.432. ⟨10.3390/cancers11030432⟩
Volume 11
Issue 3

Introduction: Based on a mathematical model of trabectedin-induced neutropenia, we assessed the predictive value of absolute neutrophil count (ANC) on progression-free survival (PFS) in an independent validation cohort of patients treated with trabec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839e097b9788ad9204ce9a1df713d016
https://hal-amu.archives-ouvertes.fr/hal-02461464

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Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

Autor: Elisabet Englund, Angelo Tortora, Roland Coras, Sebastian S. Roeder, Jonas Frisén, Joji B. Kuramatsu, Makoto Nakamura, Arnd Doerfler, Samuel Bernard, Ilker Y. Eyüpoglu, Raouf El Cheikh, Iris Muehlen, Olaf Bergmann, Mehran Salehpour, Stefan Schwab, Göran Possnert, Stephan P. Kloska, Hagen B. Huttner, Paula Heinke

Publikováno v: EBioMedicine
EBioMedicine, 2018, 27, pp.176-181. ⟨10.1016/j.ebiom.2017.12.020⟩
EBioMedicine, Elsevier, In press, 27, pp.176-181. ⟨10.1016/j.ebiom.2017.12.020⟩
EBioMedicine, Vol 27, Iss C, Pp 176-181 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4938881ece1768136349d1e15613554a
https://hal.science/hal-01671339/file/huttner2017ebiomedicine.pdf

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Exposure-Response Analyses and Disease Modeling for Selection and Confirmation of Optimal Dosing Regimen of Isatuximab in Combination Treatment in Patients with Multiple Myeloma

Autor: Helgi van de Velde, Frank Campana, Claire Brillac, Kimiko Koiwai, Jean Baptiste Fau, Fatiha Rachedi, Christine Veyrat-Follet, Dorothée Semiond, Hoai-Thu Thai, Raouf El-Cheikh, Nadia Gaudel-Dedieu, Li Liu, Bernard Sebastien, Laurent Nguyen

Publikováno v: Blood. 134:1897-1897

Background: Isatuximab (Isa) is an anti-CD38 monoclonal antibody with multiple modes of action for killing tumor cells through direct tumor targeting and immune cell engagement. Exposure-Response (E-R) analysis and disease modelling of tumor burden w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::898280446b5a0ffc7c8a5b47b4021889
https://doi.org/10.1182/blood-2019-128875

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