Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Rao Koganty"'
Autor:
R. Rao Koganty, Teresa Gilewski, Maura N. Dickler, Clifford A. Hudis, Alan N. Houghton, K. Panageas, Sonal Bhuta, Larry Norton, Govind Ragupathi, Philip O. Livingston, Jeannette Chin-Eng, Shemeeakah Powell
Publikováno v:
Clinical Cancer Research. 13:2977-2985
Purpose: To determine the clinical toxicities and antibody response against sTn and tumor cells expressing sTn following immunization of high-risk breast cancer patients with clustered sTn-KLH [sTn(c)-KLH] conjugate plus QS-21.Experimental Design: Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7974667889d2751bfc43654177fe5e2
https://doi.org/10.1158/1078-0432.ccr-06-2189
https://doi.org/10.1158/1078-0432.ccr-06-2189
Publikováno v:
Carbohydrate Research. 342:784-796
Structurally defined immunostimulatory adjuvants play important roles in the development of new generation vaccines. Here described are the syntheses of three monophosphoryl lipid A analogues (1-3) with different substitution at 3-O-position of the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327df714effc185fb894f7d736efa11
https://doi.org/10.1016/j.carres.2007.01.012
https://doi.org/10.1016/j.carres.2007.01.012
Autor:
R. Rao Koganty, Zi-Hua Jiang
Publikováno v:
Current Medicinal Chemistry. 10:1423-1439
A clear understanding of the mechanism of function of immune stimulatory adjuvants, which commonly accompany vaccines, is beginning to emerge. Recent investigations have demonstrated that Toll-like receptors (TLRs) are the critical link between the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc161eff26ba66539ce1945c78467f6
https://doi.org/10.2174/0929867033457340
https://doi.org/10.2174/0929867033457340
Autor:
Mimi V. Bach, Wladyslaw Budzynski, Mark J. Krantz, B. Michael Longenecker, Zi-Hua Jiang, R. Rao Koganty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2193-2196
Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2df99eea6663bc0ae30462b11068fdd
https://doi.org/10.1016/s0960-894x(02)00362-1
https://doi.org/10.1016/s0960-894x(02)00362-1
Publikováno v:
Glycoconjugate Journal. 17:835-848
Synthetic oligosaccharide vaccines based on core STn (sialyl α2-6 GalNAc) carbohydrate epitopes are being evaluated by a number of biopharmaceutical firms as potential immunotherapeutics in the treatment of mucin-expressing adenocarcinomas. The STn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba2c3c59191b25c16cf8f65391731bc
https://doi.org/10.1023/a:1010909011496
https://doi.org/10.1023/a:1010909011496
Autor:
R. Rao Koganty, Malcolm S. Mitchell, G D MacLean, Mark A. Reddish, B. Michael Longenecker, June Kan-Mitchell, Vicky Jones
Publikováno v:
International Journal of Cancer. 76:817-823
Sixteen metastatic breast cancer patients were immunized with a low dose (5 micrograms) of a 16 amino acid MUC1 peptide (GVTSAPDTRPAPGSTA) conjugated to KLH (BP16-KLH) plus DETOX adjuvant and evaluated for antibody titers against MUC1 peptide and KLH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43afd1f92350b6fc5d8ca68b1b02bcec
https://doi.org/10.1002/(sici)1097-0215(19980610)76:6<817::aid-ijc9>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19980610)76:6<817::aid-ijc9>3.0.co
Autor:
M J Krantz, Wladyslaw Budzynski, B. M. Longenecker, J. A. Rogers, R. Rao Koganty, H. H. Guan, Mark A. Reddish, John Samuel
Publikováno v:
Bioconjugate Chemistry. 9:451-458
Synthetic human MUC1 peptides are important candidates for therapeutic cancer vaccines. To explore whether a human MUC1 peptide BP25 (STAPPAHGVTSAPDTRPAPGSTAPP) can be rendered immunogenic by incorporation in liposomes, the effects of physical associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d9ff7cc7c7c2b280d81e96520c4fb3
https://doi.org/10.1021/bc970183n
https://doi.org/10.1021/bc970183n
Autor:
John Samuel, R. Rao Koganty, Wladyslaw Budzynski, B. M. Longenecker, G L Zimmermann, Mark A. Reddish, M J Krantz, Lei Ding
Publikováno v:
International Journal of Cancer. 75:295-302
A human MUC1-transfected mouse mammary adenocarcinoma cell line (GZHI) was used to develop both subcutaneous and intravenous tumor models. A vaccine formulation comprised of a 24 mer (human MUC1) synthetic peptide encapsulated with monophosphoryl lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8fd84d333d536554ae444b774704ba
https://doi.org/10.1002/(sici)1097-0215(19980119)75:2<295::aid-ijc20>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19980119)75:2<295::aid-ijc20>3.0.co
Publikováno v:
Glycoconjugate Journal. 15:217-221
STn (NeuAcalpha2 --> 6GalNAc alpha-O-Ser/Thr) is a carbohydrate epitope overexpressed in various human carcinomas. Clinical trials are underway using synthetic STn or STn trimeric glycopeptides [STn, cluster; STn(c)] conjugated with keyhole limpet he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d3d18d804247606e9e34c60de1fd6d
https://doi.org/10.1023/a:1006936826730
https://doi.org/10.1023/a:1006936826730
Autor:
R. Rao Koganty, Dongxu Qiu
Publikováno v:
Tetrahedron Letters. 38:961-964
Trichloroacetimidate at 1 and 3 position of 4,6-benzylidenyl N-acetylgalactosamine serves as a leaving group for glycosylation and a selective and acid sensitive protecting group respectively. This versatile donor, while forming exclusive α-glycosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b62700d0d4ab4a8cbf176565d307a98
https://doi.org/10.1016/s0040-4039(96)02490-2
https://doi.org/10.1016/s0040-4039(96)02490-2