Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rao, Kalla"'
Autor:
Robert M. Cox, Josef D. Wolf, Carolin M. Lieber, Julien Sourimant, Michelle J. Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T. Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L. Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L. Greninger, John P. Bilello, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2
Externí odkaz:
https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
Autor:
Richard L. Mackman, Rao Kalla, Darius Babusis, Jared Pitts, Kimberly T. Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B. Michael O’Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Elodie Dempah, Elaine Bunyan, Nicholas C. Riola, Xianghan Lu, Renmeng Liu, Ashley Davie, Tien-Ying Hsiang, Michael Gale, Anita Niedziela-Majka, Joy Y. Feng, Charlotte Hedskog, John P. Bilello, Raju Subramanian, Tomas Cihlar
Remdesivir1is an amidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells thereby forming the bioactive triphosphate2-NTP.2-NTP, an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f124f071d22852c94170b2ccfc17e415
https://doi.org/10.1101/2023.04.28.538473
https://doi.org/10.1101/2023.04.28.538473
Autor:
John P. Bilello, Darius Babusis, Michelle J. Lin, Venice DuPont, Carolin M. Lieber, Kwon Soo Chun, Kim T. Barrett, Chengjin Ye, Robert M. Cox, Rao Kalla, Tomas Cihlar, Diane Lye, Alexander L. Greninger, Josef D. Wolf, Richard L. Mackman, Richard K. Plemper, Julien Sourimant, Luis Martinez-Sobrido, Julie Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may boost therapeutic benefit by facilitating early administration to non-hospitalized patients
Autor:
Alexandra Schäfer, David R. Martinez, John J. Won, Rita M. Meganck, Fernando R. Moreira, Ariane J. Brown, Kendra L. Gully, Mark R. Zweigart, William S. Conrad, Samantha R. May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T. Barrett, Blake J. Bleier, Roy Bannister, Joy Y. Feng, John P. Bilello, Tomas Cihlar, Richard L. Mackman, Stephanie A. Montgomery, Ralph S. Baric, Timothy P. Sheahan
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 3
article-version (status) pre
article-version (number) 3
The coronavirus disease 2019 (COVID-19) pandemic remains uncontrolled despite the rapid rollout of safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, underscoring the need to develop highly effective antivirals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414bac2018cc4bd1b40a45769213931b
Autor:
Jennifer Tang, Timothy P. Sheahan, Stephanie A. Montgomery, Kendra Gully, John J. Won, Ariane J. Brown, Tomas Cihlar, Joy Y. Feng, Ralph S. Baric, Fernanado R Moreira, Kimberly T Barrett, Eisuke Murakami, Roy Bannister, Raju Subramanian, John P. Bilello, Richard L. Mackman, Darius Babusis, Venice Du Pont, Rao Kalla, David R. Martinez, Blake J. Bleier, Kwon Soo Chun, Alexandra Schäfer
The COVID-19 pandemic remains uncontrolled despite the rapid rollout of safe and effective SARS-CoV-2 vaccines, underscoring the need to develop highly effective antivirals. In the setting of waning immunity from infection and vaccination, breakthrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce6015bc48077307a089bd765f513bb
https://doi.org/10.1101/2021.09.13.460111
https://doi.org/10.1101/2021.09.13.460111
Autor:
Rao Kalla, Julien Sourimant, Alexander L. Greninger, Michelle Lin, Kwon Soo Chun, John P Bilello, Richard L. Mackman, Darius Babusis, Chengjin Ye, Venice Du Pont, Luis Martinez-Sobrido, Julie Chan, Robert M. Cox, Richard K. Plemper, Carolin M. Lieber, Kim T. Barrett, Tomas Cihlar, Josef D. Wolf
Remdesivir is the only small-molecule antiviral approved to date for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may boost therapeutic benefit by facilitating early administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd58dd1d75c30dae4af9b940700096c
https://doi.org/10.21203/rs.3.rs-662905/v1
https://doi.org/10.21203/rs.3.rs-662905/v1
Publikováno v:
International Journal of Vehicle Information and Communication Systems. 7:161
Autor:
Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu
Publikováno v:
Journal of Medicinal Chemistry. 59:9005-9017
Late sodium current (late INa) is enhanced during ischemia by reactive oxygen species (ROS) modifying the Nav 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-6615, eleclazine) a novel, potent, and selective inhibitor of late INa, is
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Autor:
Leanna Lagpacan, Christopher Allen Ziebenhaus, Bruno Marchand, Elfatih Elzein, Jason K. Perry, Bernard P. Murray, Scott Preston Simonovich, Parkhill Eric Q, Armando G. Villaseñor, WaiLok K. Hung, Nikos Pagratis, Rao Kalla, Jeff Zablocki, Dmitry Koltun, John R. Somoza, Timothy R. Hansen, Ron Aoyama, Thao Perry, Magdeleine Hung, Xiaofen Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
We hereby disclose the discovery of inhibitors of CaMKII (7h and 7i) that are highly potent in rat ventricular myocytes, selective against hERG and other off-target kinases, while possessing good CaMKII tissue isoform selectivity (cardiac γ/δ vs. n