Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning

Autor: Luo, Yi, Joung, Hyou-Arm, Esparza, Sarah, Rao, Jingyou, Garner, Omai, Ozcan, Aydogan

Publikováno v: Lab on a Chip (2021)

Particle agglutination assays are widely adapted immunological tests that are based on antigen-antibody interactions. Antibody-coated microscopic particles are mixed with a test sample that potentially contains the target antigen, as a result of whic

Externí odkaz: http://arxiv.org/abs/2106.01837

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Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

Autor: Estevam GO; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States.; Tetrad Graduate Program, UCSF, San Francisco, CA, United States., Linossi EM; Cardiovascular Research Institute, UCSF, San Francisco, CA, United States.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, United States., Rao J; Department of Computer Science, UCLA, Los Angeles, CA, United States., Macdonald CB; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States., Ravikumar A; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States., Chrispens KM; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States.; Biophysics Graduate Program, UCSF, San Francisco, CA, United States., Capra JA; Bakar Computational Health Sciences Institute and Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States., Coyote-Maestas W; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States.; Quantitative Biosciences Institute, UCSF, San Francisco, CA, United States., Pimentel H; Department of Computer Science, UCLA, Los Angeles, CA, United States.; Department of Computational Medicine and Human Genetics, UCLA, Los Angeles, CA, United States.; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States., Collisson EA; Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Medicine, University of Washington, Seattle, Washington, United States., Jura N; Cardiovascular Research Institute, UCSF, San Francisco, CA, United States.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, United States.; Quantitative Biosciences Institute, UCSF, San Francisco, CA, United States., Fraser JS; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, United States.; Quantitative Biosciences Institute, UCSF, San Francisco, CA, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.