RAD51B in Familial Breast Cancer

Autor: Pelttari, Liisa M., Khan, Sofia, Vuorela, Mikko, Kiiski, Johanna I., Vilske, Sara, Nevanlinna, Viivi, Ranta, Salla, Schleutker, Johanna, Winqvist, Robert, Kallioniemi, Anne, Dörk, Thilo, Bogdanova, Natalia V., Figueroa, Jonine, Pharoah, Paul D. P., Schmidt, Marjanka K., Dunning, Alison M., García-Closas, Montserrat, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Hopper, John L., Southey, Melissa C., Rosenberg, Efraim H., Fasching, Peter A., Beckmann, Matthias W., Peto, Julian, dos-Santos-Silva, Isabel, Sawyer, Elinor J., Tomlinson, Ian, Burwinkel, Barbara, Surowy, Harald, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E., Nordestgaard, Børge G., Benitez, Javier, González-Neira, Anna, Neuhausen, Susan L., Anton-Culver, Hoda, Brenner, Hermann, Arndt, Volker, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Brüning, Thomas, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Hartikainen, Jaana M., Van Dyck, Laurien, Janssen, Hilde, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Peterlongo, Paolo, Hallberg, Emily, Olson, Janet E., Giles, Graham G., Milne, Roger L., Haiman, Christopher A., Schumacher, Fredrick, Simard, Jacques, Dumont, Martine, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Zheng, Wei, Beeghly-Fadiel, Alicia, Grip, Mervi, Andrulis, Irene L., Glendon, Gord, Devilee, Peter, Seynaeve, Caroline, Hooning, Maartje J., Collée, Margriet, Cox, Angela, Cross, Simon S., Shah, Mitul, Luben, Robert N., Hamann, Ute, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Couch, Fergus J., Yannoukakos, Drakoulis, Orr, Nick, Swerdlow, Anthony, Darabi, Hatef, Li, Jingmei, Czene, Kamila, Hall, Per, Easton, Douglas F., Mattson, Johanna, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of

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RAD51B in Familial Breast Cancer.

Autor: Pelttari LM; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Khan S; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Vuorela M; Laboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland., Kiiski JI; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Vilske S; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Nevanlinna V; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Ranta S; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Schleutker J; BioMediTech, University of Tampere, Tampere, Finland.; Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.; Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland.; Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland., Kallioniemi A; BioMediTech, University of Tampere, Tampere, Finland.; Fimlab Laboratories, Tampere, Finland., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Bogdanova NV; Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany., Figueroa J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America., Pharoah PD; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Schmidt MK; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., García-Closas M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia., Southey MC; Department of Pathology, The University of Melbourne, Melbourne, Australia., Rosenberg EH; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands., Fasching PA; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.; David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California, United States of America., Beckmann MW; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Peto J; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Dos-Santos-Silva I; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Sawyer EJ; Research Oncology, Guy's Hospital, King's College London, London, United Kingdom., Tomlinson I; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Burwinkel B; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Surowy H; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Guénel P; Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.; University Paris-Sud, Villejuif, France., Truong T; Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.; University Paris-Sud, Villejuif, France., Bojesen SE; Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nordestgaard BG; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Benitez J; Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain., González-Neira A; Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain., Neuhausen SL; Beckman Research Institute of City of Hope, Duarte, California, United States of America., Anton-Culver H; Department of Epidemiology, University of California Irvine, Irvine, California, United States of America., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Meindl A; Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany., Schmutzler RK; Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Brauch H; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Margolin S; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Mannermaa A; Cancer Center, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Hartikainen JM; Cancer Center, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Chenevix-Trench G; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Van Dyck L; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Janssen H; Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rudolph A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy., Peterlongo P; IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy., Hallberg E; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America., Olson JE; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Milne RL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Schumacher F; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada., Dumont M; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada., Kristensen V; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway., Borresen-Dale AL; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Beeghly-Fadiel A; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Grip M; Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland., Andrulis IL; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Glendon G; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada., Devilee P; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Seynaeve C; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Hooning MJ; Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Collée M; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Cox A; Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom., Cross SS; Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom., Shah M; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Luben RN; Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Torres D; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America., Yannoukakos D; Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens, Greece., Orr N; Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom., Swerdlow A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom., Darabi H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Li J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Mattson J; Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Blomqvist C; Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Aittomäki K; Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Publikováno v: PloS one [PLoS One] 2016 May 05; Vol. 11 (5), pp. e0153788. Date of Electronic Publication: 2016 May 05 (Print Publication: 2016).