Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Ranpirnase"'
Autor:
Eric G. Romanowski, Kathleen A. Yates, Eric J. Daniels, Brian M. Strem, John E. Romanowski, Regis P. Kowalski
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1485 (2022)
Adenovirus ocular infections are common ocular viral infections seen worldwide, for which there is no approved antiviral therapy available. Ranpirnase is a novel ribonuclease which preferentially degrades tRNA resulting in an inhibition of protein sy
Externí odkaz:
https://doaj.org/article/e6dfd7ae89a540419bd1f53424162552
Akademický článek
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Autor:
Todd G. Smith, Felix R. Jackson, Clint N. Morgan, William C. Carson, Brock E. Martin, Nadia Gallardo-Romero, James A. Ellison, Lauren Greenberg, Thomas Hodge, Luis Squiquera, Jamie Sulley, Victoria A. Olson, Christina L. Hutson
Publikováno v:
Viruses, Vol 12, Iss 2, p 177 (2020)
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity. TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated ag
Externí odkaz:
https://doaj.org/article/71fa94ae4d28456faa8722a4ab986a90
Publikováno v:
Drug and Drug Abuse. :1-8
A novel approach of antitumor treatment, that involves targeting RNA either using specific antisense oligonucleotides or cytostatic/cytotoxic ribonucleases (RNases), is being promoted. Among recently described cytotoxic RNases, amphibian RNases, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48ef4170e0090785aaa9c064415bcfa
https://doi.org/10.31487/j.dda.2020.01.04
https://doi.org/10.31487/j.dda.2020.01.04
Autor:
Luciano Mutti, Giovanni Gaudino
Publikováno v:
Oncology Reviews, Vol 2, Iss 1, Pp 61-65 (2011)
Ribonucleases are a superfamily of RNA-cleaving enzymes that can be cytotoxic since the cleavage of RNA makes its information indecipherable. Ranpirnase is a novel ribonuclease which preferentially degrades tRNA, thus leading to an inhibition of prot
Externí odkaz:
https://doaj.org/article/84b5497be7ce42c2bcdc1545ed84c7ea
Autor:
Sandra Jordaan, Olusiji A. Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 6, Iss 1, p 28 (2018)
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic pro
Externí odkaz:
https://doaj.org/article/66c4f9f9103a4660be7438b5d9de26a3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Christina L. Hutson, Felix R. Jackson, Clint N Morgan, William C. Carson, Jamie Sulley, Todd G. Smith, Thomas Hodge, Lauren Greenberg, Brock E. Martin, James A. Ellison, Luis Squiquera, Nadia F. Gallardo-Romero, Victoria A. Olson
Publikováno v:
Viruses
Viruses, Vol 12, Iss 2, p 177 (2020)
Volume 12
Issue 2
Viruses, Vol 12, Iss 2, p 177 (2020)
Volume 12
Issue 2
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity. TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bdfaeb7d91beea2eb3b3d30b0a2dbc
https://pubmed.ncbi.nlm.nih.gov/32033253
https://pubmed.ncbi.nlm.nih.gov/32033253
Publikováno v:
Cytometry Part A. 95:683-690
Described is the new cytometric approach do detect either stimulation or a collapse of lysosomal proton pump (lysosomes rupture) combined with activation of transglutaminase 2 (TG2) during induction of apoptosis. Apoptosis of human lymphoblastoid TK6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b825d73ceeca0d1d7972901869e28
https://doi.org/10.1002/cyto.a.23652
https://doi.org/10.1002/cyto.a.23652
Autor:
Randall E. Brand, Jamie Sulley, Ashley Myerski, E. Metter, Thomas W. Hodge, Jarret Engstrom, Aaron Siegel, Ian McGowan, Rhonda M. Brand, Luis Squiquera, Ross D. Cranston
Publikováno v:
AIDS Research and Human Retroviruses. 34:838-848
Ranpirnase (RNP) is a low molecular weight type III endoribonuclease, which demonstrates broad antiviral and antitumor properties. We sought to characterize the antiviral activity of RNP against HIV-1 and to determine whether RNP modulates local infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdd1a6977f92f1fe2d23316829e8185
https://doi.org/10.1089/aid.2017.0308
https://doi.org/10.1089/aid.2017.0308