Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ranmal A. Samarasinghe"'
Autor:
Ranmal A. Samarasinghe, Prasad S. Kanuparthi, J. Timothy Greenamyre, Donald B. DeFranco, Roberto Di Maio
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 252-261 (2014)
While aberrant cell proliferation and differentiation may contribute to epileptogenesis, the mechanisms linking an initial epileptic insult to subsequent changes in cell fate remain elusive. Using both mouse and human iPSC-derived neural progenitor/s
Externí odkaz:
https://doaj.org/article/b9a3185841d84a14a7a62b5bdbec7856
Autor:
Ranmal A. Samarasinghe, Prasad S. Kanuparthi, J. Timothy Greenamyre, Donald B. DeFranco, Roberto DiMaio
Publikováno v:
Neurobiology of Disease, Vol 71, Iss , Pp 43- (2014)
Externí odkaz:
https://doaj.org/article/ee4623dfa4d5477fb1607c9d2a0921ee
Autor:
Andrew J. Lund, Istvan Mody, John Huang, Inma Cobos, William E. Lowry, Marcos Otero-Garcia, Justin Langerman, Ranmal A. Samarasinghe, Kathrin Plath, Damon Polioudakis, Shan Sabri, Xiaofei Wei, Bennett G. Novitch, Daniel H. Geschwind, Thomas F. Allison
Publikováno v:
Stem cell reports, vol 16, iss 10
Stem Cell Reports
Stem Cell Reports
Summary The specification of inhibitory neurons has been described for the mouse and human brain, and many studies have shown that pluripotent stem cells (PSCs) can be used to create interneurons in vitro. It is unclear whether in vitro methods to pr
Autor:
Bennett G. Novitch, Momoko Watanabe, Arinnae Kurdian, Jessie E. Buth, Thomas F. Allison, William E. Lowry, Istvan Mody, Kathrin Plath, Jack M. Parent, Peyman Golshani, Osvaldo A. Miranda, Ranmal A. Samarasinghe, Simon Mitchell, Namie N. Fotion, Isabella Ferando, Michael J. Gandal
Publikováno v:
Nature neuroscience, vol 24, iss 10
Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and structure. However, many diseases manifest with clear evidence of physiological and network abnormality in the absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c288d4f42d433f0860576f9b81455b6d
https://escholarship.org/uc/item/8kj286zq
https://escholarship.org/uc/item/8kj286zq
Autor:
Thomas F. Allison, Jessie E. Buth, Simon Mitchell, Istvan Mody, William E. Lowry, Kathrin Plath, Jack M. Parent, Osvaldo A. Miranda, Arinnae Kurdian, Michael J. Gandal, Isabella Ferando, Ranmal A. Samarasinghe, Peyman Golshani, Namie N. Fotion, Bennett G. Novitch, Momoko Watanabe
Brain organoids represent a powerful tool for the study of human neurological diseases, particularly those impacting brain growth and structure. However, many diseases manifest with clear evidence of physiological and network abnormality in the absen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96ccef136463f73192e3bfa28d309e0
https://doi.org/10.1101/820183
https://doi.org/10.1101/820183
Autor:
Roberto Di Maio, Prasad S. Kanuparthi, Donald B. DeFranco, Ranmal A. Samarasinghe, J. Timothy Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 70, Iss, Pp 252-261 (2014)
While aberrant cell proliferation and differentiation may contribute to epileptogenesis, the mechanisms linking an initial epileptic insult to subsequent changes in cell fate remain elusive. Using both mouse and human iPSC-derived neural progenitor/s
Cooperativity and complementarity: Synergies in non-classical and classical glucocorticoid signaling
Publikováno v:
Cell Cycle. 11:2819-2827
Glucocorticoids (GCs) are an ubiquitous class of steroid hormones that exert a wide array of physiological effects. Traditionally, GC action has been considered to primarily involve transcriptional effects following the binding of hormone to the gluc
Autor:
Daniela Volonte, Marcia Lewis, Donald B. DeFranco, Ranmal A. Samarasinghe, Guillermo Romero, Roberto Di Maio, Ferruccio Galbiati
Publikováno v:
Proceedings of the National Academy of Sciences. 108:16657-16662
Glucocorticoids (GCs) are used to treat pregnant women at risk for preterm delivery; however, prenatal exposure to GCs may trigger adverse neurological side effects due to reduced neural progenitor cell (NPC) proliferation. Whereas many established c
Autor:
James W. Bales, Hong Q. Yan, C. Edward Dixon, Xiecheng Ma, Ranmal A. Samarasinghe, Youming Li
Publikováno v:
Experimental Neurology. 229:300-307
Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in e
Autor:
Elias Aizenman, Yeung Ho, Donald B. DeFranco, Ranmal A. Samarasinghe, Marcia Lewis, Megan E. Knoch
Publikováno v:
Molecular Pharmacology. 74:1141-1151
Oxidative stress induced by glutathione depletion in the mouse HT22 neuroblastoma cell line and embryonic rat immature cortical neurons causes a delayed, sustained activation of extracellular signal-regulated kinases-1/2 (ERK1/2), which is required f