Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ranjodh Sandhu"'
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT RAP1 is a telomere protein that is well conserved from protozoa to mammals. It plays important roles in chromosome end protection, telomere length control, and gene expression/silencing at both telomeric and nontelomeric loci. Interaction wi
Externí odkaz:
https://doaj.org/article/80c4e73956134255abe3a3f04b1cd2ba
Autor:
Vishal Nanavaty, Rati Lama, Ranjodh Sandhu, Bo Zhong, Daniel Kulman, Viharika Bobba, Anran Zhao, Bibo Li, Bin Su
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146289 (2016)
OBJECTIVES:There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates
Externí odkaz:
https://doaj.org/article/d5972f84c8d44028a728d7845a67942a
Autor:
Tapati Mazumdar, Ranjodh Sandhu, Maha Qadan, Jennifer DeVecchio, Victoria Magloire, Akwasi Agyeman, Bibo Li, Janet A Houghton
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75253 (2013)
The Hedgehog (HH) signaling pathway is critical for normal embryonic development, tissue patterning and cell differentiation. Aberrant HH signaling is involved in multiple human cancers. HH signaling involves a multi-protein cascade activating the GL
Externí odkaz:
https://doaj.org/article/80debe48a46b46d2bcc2feb9df6e996c
Autor:
Amit Kumar Gaurav, Marjia Afrin, Arpita Saha, Unnati M. Pandya, Ranjodh Sandhu, Bibo Li, Brittny Schnur, Vishal Nanavaty
Publikováno v:
Nucleic Acids Research
Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to evade the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf318b82767cf5a5fc412ddf553ecd5
https://doi.org/10.1093/nar/gkab401
https://doi.org/10.1093/nar/gkab401
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 30
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 30
In addition to mediating telomerase recruitment, shelterin protein TPP1 also stimulates telomerase processivity. Assessing the in vivo significance of the latter role of TPP1 has been difficult, as TPP1 mutations that perturb telomerase function tend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3031aacc4f1e2f6505c4988cfc58c5df
https://europepmc.org/articles/PMC8325329/
https://europepmc.org/articles/PMC8325329/
Publikováno v:
Biochemical and Biophysical Research Communications. 512:230-235
The shelterin protein complex protects natural chromosome ends from being recognized as DNA damage sites and also regulates the synthesis of telomeric repeats by telomerase. TPP1, a shelterin subunit that is essential for telomerase extension of telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fe609694908c0fa63ee453bbbd0498
https://doi.org/10.1016/j.bbrc.2019.03.050
https://doi.org/10.1016/j.bbrc.2019.03.050
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00027-20 (2020)
mSphere
mSphere, Vol 5, Iss 1, p e00027-20 (2020)
mSphere
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. TbRAP1, a telomere protein, is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439c6f5806cd6941016e0d8f428c2777
https://journals.asm.org/doi/10.1128/mSphere.00027-20
https://journals.asm.org/doi/10.1128/mSphere.00027-20
Publikováno v:
Nucleic Acids Research
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, thereby evading the host's immune response. VSGs are monoallelically expressed from subtelomeric expression sites (ESs), and VSG switching
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ab51d69037f90b7fe9e07de4b6260b
https://doi.org/10.1093/nar/gkx184
https://doi.org/10.1093/nar/gkx184
Autor:
Ranjodh Sandhu, Bibo Li
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Trypanosoma brucei causes fatal human African trypanosomiasis and evades the host immune response by regularly switching its major surface antigen, VSG, which is expressed exclusively from subtelomeric loci. Telomere length and telomere proteins play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ee3dcf9bbd3c6ada2a31e318f6544f
http://europepmc.org/articles/PMC5700094
http://europepmc.org/articles/PMC5700094
Autor:
Imaan Benmerzouga, Xiaohua Li, Sanaa E. Jehi, Fei Ye, Ranjodh Sandhu, Yanxiang Zhao, Mingjie Zhang, Bibo Li
Publikováno v:
Nucleic Acids Research
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, in the bloodstream of its mammalian host to evade the host immune response. VSGs are expressed exclusively from subtelomeric loci, and we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476ee005efa75407bea81fef4116de76
https://pubmed.ncbi.nlm.nih.gov/25313155
https://pubmed.ncbi.nlm.nih.gov/25313155