Výsledky vyhledávání - "Ranjit S. Sidhu"

The HB22.7–vcMMAE antibody–drug conjugate has efficacy against non-Hodgkin lymphoma mouse xenografts with minimal systemic toxicity

Autor: Emily Tuscano, Gustavo A. Barisone, Mastewal Abuhay, Jason Kato, Robert T. O'Donnell, Ranjit S. Sidhu, Joseph Tuscano

Publikováno v: Cancer immunology, immunotherapy : CII, vol 65, iss 10
Cancer Immunol Immunother

In this study, the HB22.7 anti-CD22 mAb, was used for specific, targeted delivery of the potent anti-cancer agent, monomethyl auristatin E (MMAE) to non-Hodgkin lymphoma (NHL). MMAE was covalently coupled to HB22.7 through a valine-citrulline peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0851ce34208080ebdc9b78773ef13fe
https://doi.org/10.1007/s00262-016-1873-y

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Efficacy of Combined Histone Deacetylase and Checkpoint Kinase Inhibition in a Preclinical Model of Human Burkitt Lymphoma

Autor: YanGuo Kong, Gustavo A. Barisone, Joseph Tuscano, Robert T. O'Donnell, Ranjit S. Sidhu

Publikováno v: Molecular Medicine. 21:824-832

Checkpoint kinase inhibition has been studied as a way of enhancing the effectiveness of DNA-damaging agents. More recently, histone deacetylase inhibitors have shown efficacy in several cancers, including non-Hodgkin lymphoma. To evaluate the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf232409fbebcb0a6f8ecf9b65d7929
https://doi.org/10.2119/molmed.2015.00032

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