Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Ranjit Ray"'
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Hepatitis C virus (HCV) is characterized by a high number of chronic cases due to an impairment of protective innate and adaptive immune responses. Here, we examined the contribution of the individual ectodomains of E1, E2, or a modified E2
Externí odkaz:
https://doaj.org/article/4daf3bd8fb9c4e03b4aa1ee6fdd02d7b
Autor:
Tapas Patra, Ranjit Ray
Publikováno v:
Journal of Inflammation, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Background Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein expressed epithelial cel
Externí odkaz:
https://doaj.org/article/8951f8a07d2f48b4938d555d563f4ebb
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-8 (2021)
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancy-related deaths. p53 mutation in HCC associates with worse clinicopathologic features including therapeutic limitation. A combination of targeted therapy may have some advant
Externí odkaz:
https://doaj.org/article/3e23d0b8a3bc45bab032fe4d6ec552a6
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces inflammatory response, cytokine storm, venous thromboembolism, coagulopathy, and multiple organ damage. Resting endothelial cells prevent coagulation, control blo
Externí odkaz:
https://doaj.org/article/641ba9a1e57d489db287fab8b41a9425
Autor:
Tapas Patra, Keith Meyer, Lizzie Geerling, T Scott Isbell, Daniel F Hoft, James Brien, Amelia K Pinto, Ratna B Ray, Ranjit Ray
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009128 (2020)
Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2 infection, although the mechanism for initiation of a hyper-inflammatory response, and multi-organ damage from viral infection is poorly understood. In this vi
Externí odkaz:
https://doaj.org/article/3a8082e06d9942d88e7c2e4965d699ec
Publikováno v:
Cells, Vol 8, Iss 3, p 274 (2019)
Innate immune responses generate interferons, proinflammatory cytokines, complement activation, and natural killer (NK) cell response. Ultimately, this leads to the induction of a robust virus-specific adaptive immunity. Although the host innate immu
Externí odkaz:
https://doaj.org/article/0be555248ba84068b0f4a45245b6aa81
Publikováno v:
Viruses, Vol 2, Iss 9, Pp 2108-2133 (2010)
Chronic hepatitis C virus (HCV) infection is a major risk factor for liver disease progression, and may lead to cirrhosis and hepatocellular carcinoma (HCC). The HCV genome contains a single-stranded positive sense RNA with a cytoplasmic lifecycle. H
Externí odkaz:
https://doaj.org/article/cbe3f8dfd5be4a67b157cebba57472c5
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101422 (2014)
We have previously reported that in vitro HCV infection of cells of hepatocyte origin attenuates complement system at multiple steps, and attenuation also occurs in chronically HCV infected liver, irrespective of the disease stage. However, none of t
Externí odkaz:
https://doaj.org/article/c71ef473d75e474881c705abd6fa7d28
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44461 (2012)
Activated hepatic stellate cells (HSCs) are the major source for alteration of extracellular matrix in fibrosis and cirrhosis. Conditioned medium (CM) collected from immortalized human hepatocytes (IHH) have earlier been shown to be responsible for a
Externí odkaz:
https://doaj.org/article/1be894151fd74f3eae1f0e0b4a526804
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23699 (2011)
We have completed a phase 1 safety and immunogenicity trial with hepatitis C virus (HCV) envelope glycoproteins, E1 and E2, with MF59 adjuvant as a candidate vaccine. Neutralizing activity to HCV genotype 1a was detected in approximately 25% of the v
Externí odkaz:
https://doaj.org/article/7ddb72601f084e25a8785fc94c658a43