Výsledky vyhledávání - "Ranjit Kumar Mehta"

Zinc-Oxide Nanoparticles Exhibit Genotoxic, Clastogenic, Cytotoxic and Actin Depolymerization Effects by Inducing Oxidative Stress Responses in Macrophages and Adult Mice

Autor: Ranjit Kumar Mehta, Rojalin Sahu, Rashmirekha Pati, Avinash Sonawane, Ishani Das

Publikováno v: Toxicological Sciences. 150:454-472

Zinc oxide nanoparticles (ZnO-NPs) have wide biological applications, which have raised serious concerns about their impact on the health and environment. Although, various studies have shown ZnO-NP toxicity on different cells underin vitroconditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c4bb0755afdcd674a06c6c70123c78
https://doi.org/10.1093/toxsci/kfw010

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Improvement of stability and enzymatic activity by site-directed mutagenesis of E. coli asparaginase II

Autor: Ranjit Kumar Mehta, Shikha Verma, Prasanta Kumar Maiti, Klaus-Heinrich Röhm, Avinash Sonawane

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844:1219-1230

Bacterial asparaginases (EC 3.5.1.1) have attracted considerable attention because enzymes of this group are used in the therapy of certain forms of leukemia. Class II asparaginase from Escherichia coli (EcA), a homotetramer with a mass of 138 kDa, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7796dbee054d389f773f915b4bb374bf
https://doi.org/10.1016/j.bbapap.2014.03.013

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Mutations in Subunit Interface and B-cell Epitopes Improve Antileukemic Activities of Escherichia coli Asparaginase-II

Autor: Santosh K. Kar, Rabindra Kumar Jena, Mitali Sengupta, Chitra Mandal, Sudha Sethy, Shikha Verma, Ranjit Kumar Mehta, Klaus H. Roehm, Rashmirekha Pati, Biswajit Khatua, Avinash Sonawane

Publikováno v: Journal of Biological Chemistry. 289:3555-3570

l-Asparaginase-II from Escherichia coli (EcA) is a central component in the treatment of acute lymphoblastic leukemia (ALL). However, the therapeutic efficacy of EcA is limited due to immunogenicity and a short half-life in the patient. Here, we perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e2b218ad679a74c72659f92dae5f908
https://doi.org/10.1074/jbc.m113.486530

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Cationic Antimicrobial Peptides and Biogenic Silver Nanoparticles Kill Mycobacteria without Eliciting DNA Damage and Cytotoxicity in Mouse Macrophages

Autor: Ranjit Kumar Mehta, Birendranath Banerjee, Soumitra Mohanty, Satish V. Patil, Rashmirekha Pati, Prajna Jena, Avinash Sonawane

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:3688-3698

With the emergence of multidrug-resistant mycobacterial strains, better therapeutic strategies are required for the successful treatment of the infection. Although antimicrobial peptides (AMPs) and silver nanoparticles (AgNPs) are becoming one of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae59eab8e0501cefb93a4dc3c01ef34
https://doi.org/10.1128/aac.02475-12

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Mutations in subunit interface and B-cell epitopes improve antileukemic activities of Escherichia coli asparaginase-II: evaluation of immunogenicity in mice

Autor: Ranjit Kumar, Mehta, Shikha, Verma, Rashmirekha, Pati, Mitali, Sengupta, Biswajit, Khatua, Rabindra Kumar, Jena, Sudha, Sethy, Santosh K, Kar, Chitra, Mandal, Klaus H, Roehm, Avinash, Sonawane

Publikováno v: The Journal of biological chemistry. 289(6)

L-Asparaginase-II from Escherichia coli (EcA) is a central component in the treatment of acute lymphoblastic leukemia (ALL). However, the therapeutic efficacy of EcA is limited due to immunogenicity and a short half-life in the patient. Here, we perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::032cb191aeff9a8d86d847ce7871fdd0
https://pubmed.ncbi.nlm.nih.gov/24297177

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Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages

Autor: Ranjit Kumar Mehta, Soumitra Mohanty, Chandan Goswami, Baskarlingam Vaseeharan, Mitali Sengupta, Avinash Padhi, Avinash Sonawane, Rashmirekha Pati

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine. 10(6)

Here we studied immunological and antibacterial mechanisms of zinc oxide nanoparticles (ZnO-NPs) against human pathogens. ZnO-NPs showed more activity against Staphylococcus aureus and least against Mycobacterium bovis -BCG. However, BCG killing was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244c28e668b3c09412b4cbb0041c26dc
https://pubmed.ncbi.nlm.nih.gov/24607937

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