Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ranjit K Thirumaran"'
Autor:
Lindsay S Elliott, John C Henderson, Moni B Neradilek, Nicolas A Moyer, Kristine C Ashcraft, Ranjit K Thirumaran
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170905 (2017)
BACKGROUND:In polypharmacy patients under home health management, pharmacogenetic testing coupled with guidance from a clinical decision support tool (CDST) on reducing drug, gene, and cumulative interaction risk may provide valuable insights in pres
Externí odkaz:
https://doaj.org/article/0b19b94ed103485789a8f333703ac668
Autor:
Selma Ugurel, Ranjit K Thirumaran, Sandra Bloethner, Andreas Gast, Antje Sucker, Jan Mueller-Berghaus, Werner Rittgen, Kari Hemminki, Jürgen C Becker, Rajiv Kumar, Dirk Schadendorf
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e236 (2007)
In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulates tumor cell proliferation and survival. A varying mutation rate has been reported for B-RAF and N-RAS, which has been largely attributed to the diff
Externí odkaz:
https://doaj.org/article/608cc1ba66ff49af95b7b7473eb75a73
Publikováno v:
Personalized medicine. 13(1)
Approximately US$3.5 billion is spent annually as a result of adverse drug events (ADEs) [1], responsible for approximately a third of rehospitalizations and resulting in more than 700,000 annual emergency department visits by Medicare patients [2].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc43a59a3e2cfc323f47881614ecfc43
https://pubmed.ncbi.nlm.nih.gov/29749863
https://pubmed.ncbi.nlm.nih.gov/29749863
Autor:
Erin G. Schuetz, Yiping Fan, Ranjit K. Thirumaran, Xia Yang, Kazuto Yasuda, Stephen C. Strom, Amarjit S. Chaudhry
Publikováno v:
Drug Metabolism and Disposition. 41:1538-1547
Human liver gene regulatory (Bayesian) network analysis was previously used to identify a cytochrome P450 (P450) gene subnetwork with Aldo-keto reductase 1D1 (AKR1D1) as a key regulatory driver of this subnetwork. This study assessed the biologic imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a9db68cdb3d36c5d352af5645440c7
https://doi.org/10.1124/dmd.113.051672
https://doi.org/10.1124/dmd.113.051672
Autor:
Ko Fujimori, Soghra Fatima, Ranjit K. Thirumaran, Cynthia Cline, Brian P. Sorrentino, Kazuto Yasuda, Mihaela Onciu, Peter Vogel, Erin G. Schuetz, Sean Ekins, Yoshihiro Urade
Publikováno v:
Drug Metabolism and Disposition. 41:923-931
The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF barrier. However, despite the fact that drugs are administered into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3846bfde623f6828c07379adff0314
https://doi.org/10.1124/dmd.112.050344
https://doi.org/10.1124/dmd.112.050344
Autor:
Mary V. Relling, Victoria M. Pratt, Michael Pacanowski, Urs A. Meyer, Deborah A. Nickerson, Ranjit K. Thirumaran, C Bruckner, Rhn van Schaik, Teri E. Klein, Kelly E. Caudle, Matthias Schwab, Elspeth A. Bruford, Toinette Hartshorne, Rachel F. Tyndale, Wendy S. Rubinstein, AL Del Tredici, Sotiria Boukouvala, Robert R. Freimuth, M Lindqvist Appell, Gillian C. Bell, A Roberts, Howard L. McLeod, Katrin Sangkuhl, Maglott, Volker M. Lauschke, Lisa V. Kalman, Ulrich M. Zanger, Robin E. Everts, Ktj Yeo, JT den Dunnen, Daniel J. Müller, Gwendolyn A. McMillin, David A. Flockhart, H Hachad, Michelle Whirl-Carrillo, Jag Agúndez, A. Gaedigk, Lorraine Toji, Sarah C. Sim, Stuart A. Scott, Katarzyna Drozda, Ann K. Daly, John L. Black, Magnus Ingelman-Sundberg, Sally A. Coulthard, William S. Oetting
Publikováno v:
Clinical Pharmacology and Therapeutics, 99(2), 172-185
Clinical Pharmacology & Therapeutics, 99(2), 172-185. Wiley-Blackwell
Clinical Pharmacology & Therapeutics, 99(2), 172-185. Wiley-Blackwell
This manuscript provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfbf51cd9532fd1cbe69fa7e487ef33
http://hdl.handle.net/1887/113787
http://hdl.handle.net/1887/113787
Autor:
Mei Ling Chen, Paul W. Stewart, Ranjit K. Thirumaran, Katarina Ilic, Erin G. Schuetz, Celeste Lindley, Roy L. Hawke, Angela D. M. Kashuba, J. Heyward Hull
Publikováno v:
Drug Metabolism and Disposition. 41:575-581
The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro. Race/ethnic differences in CYP2B6 genotype and phenotype were observed only in women. To id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a69c0b688418f196d8ad67fc0c2f70
https://doi.org/10.1124/dmd.112.048108
https://doi.org/10.1124/dmd.112.048108
Autor:
Sabrina Angelini, Dominique Scherer, Eduardo Nagore, Rafael Botella-Estrada, Kari Hemminki, Ranjit K. Thirumaran, Justo Lorenzo Bermejo, Adina Figl, Dirk Schadendorf, Rajesh Kumar
Publikováno v:
International Journal of Cancer. 125:1868-1875
Variation within the melanocortin receptor 1 (MC1R) gene, that influences phenotypic traits and susceptibility to melanoma, is abundant across the populations. We assessed and compared the risk of melanoma in 2 European populations, German and Spanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6aa3fb1adf7afb73cca28f784c2bed4
https://doi.org/10.1002/ijc.24548
https://doi.org/10.1002/ijc.24548
Autor:
Justo Lorenzo Bermejo, Adina Figl, Elke Dickes, Dominique Scherer, Rajesh Kumar, Kari Hemminki, Ranjit K. Thirumaran, Eduardo Nagore, Dirk Schadendorf, Andreas Gast
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 661:78-84
Single nucleotide polymorphisms, besides influencing susceptibility can potentially alter progression and survival in melanoma patients. In this study we evaluated the association of polymorphisms in the base-excision repair genes XRCC1 and APEX1 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eab6d1f1c623c624d9e0c32cc4e68d
https://doi.org/10.1016/j.mrfmmm.2008.11.011
https://doi.org/10.1016/j.mrfmmm.2008.11.011
Cytochrome P-450 gene and drug interaction analysis in patients referred for pharmacogenetic testing
Autor:
John R. White, Jarrod W. Heck, Richard Newman, Kristine C. Ashcraft, Brian Thomas Hocum, Ranjit K. Thirumaran, Nicolas A. Moyer
Publikováno v:
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 73(2)
Purpose The results of a study of variant cytochrome P-450 (CYP) alleles and associated risks of drug–drug interactions (DDIs) and altered drug metabolism are reported. Methods The records of a pharmacogenetic testing laboratory were retrospectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf9282069d1d7daf1a8655e49c10d25
https://pubmed.ncbi.nlm.nih.gov/26721535
https://pubmed.ncbi.nlm.nih.gov/26721535