Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ranjit C. Desai"'
Autor:
Krishnarup Ghoshdastidar, Hoshang Patel, Hitesh Bhayani, Ankit Patel, Kinjal Thakkar, Dinesh Patel, Manoranjan Sharma, Jaideep Singh, Jogeswar Mohapatra, Abhijit Chatterjee, Dipam Patel, Rajesh Bahekar, Rajiv Sharma, Lakshmikant Gupta, Nirmal Patel, Poonam Giri, Nuggehally R. Srinivas, Mukul Jain, Debdutta Bandyopadhyay, Pankaj R. Patel, Ranjit C. Desai
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK inhi
Externí odkaz:
https://doaj.org/article/426ccabb23744fc0aceb0a7d29b505f0
Autor:
Krishnarup Ghoshdastidar, Jeevan Kumar, Jogeswar Mahapatra, Ranjit C. Desai, Dipam Patel, Debdutta Bandyopadhyay, S. Sachchidanand, Purvi Vyas, Rajesh Bahekar, Radhika Funde, Abhijit Chatterjee, Poonam Giri, Shubhangi S. Soman, Bhushan N. Dave, Rajendra Chopade
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1313-1319
PI3Kδ is implicated in various inflammatory and autoimmune diseases. For the effective treatment of chronic immunological disorders such as rheumatoid arthritis, it is essential to develop isoform selective PI3Kδ inhibitors. Structure guided optimi
Publikováno v:
2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviews
2020 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66cb41a68d5ff010a9a743254ec0dfc
https://doi.org/10.29200/acsmedchemrev-v55.ch20
https://doi.org/10.29200/acsmedchemrev-v55.ch20
Autor:
Dinesh Patel, Dipam Patel, Pankaj R. Patel, Jogeswar Mohapatra, Hoshang Patel, Krishnarup Ghoshdastidar, Abhijit Chatterjee, Rajiv P. Sharma, Mukul R. Jain, Jaideep Singh, Manoranjan Sharma, Poonam Giri, Kinjal Thakkar, Debdutta Bandyopadhyay, Rajesh Bahekar, Hitesh Bhayani, Ranjit C. Desai, Ankit Patel, Lakshmikant Gupta, Nuggehally R. Srinivas, Nirmal Patel
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK inhibitor tha
Autor:
Jogeswar Mohapatra, Sandeep A. Shedage, Poonam Giri, Pravin Kadam, Ranjit C. Desai, Krishnarup Ghoshdastidar, Harilal Patel, Hitesh Bhayani, Brijesh Kumar Srivastava, Nuggehally R. Srinivas, Ankit Patel, Debdutta Bandhyopadhyay, Prakash Patel, Abhijit Chatterjee, Rajesh Sundar, Mukul R. Jain, Laxmikant Gupta, Pankaj R. Patel, Dinesh Patel
Publikováno v:
Cancer Chemotherapy and Pharmacology. 82:635-647
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in the detection and repair of DNA damage. Studies have shown that inhibition of PARP and Tankyrase (TNKS) has significant antitumor effect in several types of cancers including BRCA
Publikováno v:
Journal of Medicinal Chemistry. 61:10976-10995
The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc) is a key transcription factor for the production of pro-inflammatory cytokines implicated in the pathogenesis of autoimmune diseases. Recently, small molecule i
Autor:
Amit Joharapurkar, Mukul R. Jain, Ranjit C. Desai, Vishal Patel, Samadhan Kshirsagar, Pankaj R. Patel, Harilal Patel, Pradip Jadav, Rajesh Bahekar
Publikováno v:
British Journal of Pharmacology. 174:2346-2357
Background and Purpose Dipeptidyl peptidase (DPP)-4 inhibitors increase levels of glucagon-like peptide-1 (GLP-1) and provide clinical benefit in the treatment of type 2 diabetes mellitus. As longer acting inhibitors have therapeutic advantages, we d
Autor:
Ranjit C. Desai, Mukul R. Jain, Vishal Patel, Amit Joharapurkar, Ashok Ghoghari, Pankaj R. Patel, Prakash Patel, Harilal Patel, Nuggehally R. Srinivas, Nirav Modi, Samadhan Kshirsagar, Rajesh Bahekar
Publikováno v:
Drug Research. 67:223-227
ZYDPLA1 is a long acting enzyme dipeptidyl peptidase-4 (DPP-4) inhibitor. The comparative effect of DPP-4 inhibition after intravenous (IV) and oral administration of ZYDPLA1 in a rat model was evaluated to answer the question of route dependency and
Autor:
Dipam Patel, Ranjit C. Desai, Darshan A. Joshi, Amitgiri D. Goswami, Sameer Agarwal, Jignesh P. Pethani, Pradip Jadav, Rajesh Bahekar, Hardik A. Shah, Bhushan N. Dave
Publikováno v:
Organic Process Research & Development. 21:266-272
Hexahydrocyclopentapyrrolone derivatives constitute an important class of bicycles, and it represents an essential pharmacophore for diversified pharmacological activities. A highly efficient process for the synthesis of tert-butyl(3aR,6aS)-5-oxohexa
Autor:
Bhavesh Gevriya, Vrajesh Pandya, Samadhan Kshirsagar, Vishal Patel, Nuggehally R. Srinivas, Amit Joharapurkar, Prakash Patel, Ranjit C. Desai, Mukul R. Jain, Pankaj R. Patel, Harilal Patel
Publikováno v:
Xenobiotica. 48:37-44
1. ZYAN1 is a prolyl hydroxylase inhibitor in clinical development for treatment of anemia associated with chronic kidney disease (CKD). We evaluated the effect of acute and chronic kidney impairment on the pharmacokinetics of ZYAN1 in rat models.2.