Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ranjit, Ramachandran"'
Autor:
Balaji, Muralikrishnan, Lekshmi K, Edison, Azger, Dusthackeer, G R, Jijimole, Ranjit, Ramachandran, Aravind, Madhavan, Ramakrishnan Ajay, Kumar
Publikováno v:
The Journal of Antibiotics. 75:226-235
Novel anti-tuberculosis drugs are essential to manage drug-resistant tuberculosis, caused by Mycobacterium tuberculosis. We recently reported the antimycobacterial activity of chrysomycin A in vitro and in infected macrophages. In this study, we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fdd2f4cb424a5af87a6715091913be
https://doi.org/10.1038/s41429-022-00503-z
https://doi.org/10.1038/s41429-022-00503-z
Autor:
Reji Jg, Ajay Kumar R, Aravind Madhavan, Edison Lk, Balaji Muralikrishnan, Dusthackeer A, Ranjit Ramachandran
Novel anti-tuberculosis drugs are essential to manage drug resistant tuberculosis, caused by the notorious pathogen Mycobacterium tuberculosis. We recently reported the antimycobacterial activity of chrysomycin A in vitro and in infected macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f0c8e2355bd9c37cd88427b132a2a51
https://doi.org/10.1101/2021.06.23.449690
https://doi.org/10.1101/2021.06.23.449690
Autor:
Laiza K. Paul, Vipin Mohan Dan, Vinodh J S, Ranjit Ramachandran, Retnakumar R J, Balaji Muralikrishnan, Syed G. Dastager, Ajay Kumar Ramakrishnan, Arun K B, Nijisha M
Conditioning of morphology is an effective technique to enhance secondary metabolite production by Streptomyces. Here we report a novel conditioning method employing glass marbles in batch cultures to enhance secondary metabolite production by Strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e574409ad20134418cc753c72693ea5d
https://doi.org/10.1101/2020.05.27.118091
https://doi.org/10.1101/2020.05.27.118091
Publikováno v:
FEBS lettersReferences. 594(17)
Rv1019, a member of an uncharacterized tetracycline resistance regulator family of transcriptional regulators of Mycobacterium tuberculosis H37Rv, was found to be differentially expressed during dormancy and reactivation in vitro. In this study, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a0653669c3ab5695be09975f7f4b08
https://pubmed.ncbi.nlm.nih.gov/32533861
https://pubmed.ncbi.nlm.nih.gov/32533861
Regulation of gene expression at the level of transcription is one of the ways living organisms differentially make proteins in their cells. Intracellular pathogen Mycobacterium tuberculosis persists in the host for years in a latent state in structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f5ab41acad22edef4ac77f709e0d20
Autor:
Ranjit Ramachandran, Ramakrishnan Ajay Kumar, Roshna Lawrence Gomez, Anand K. Kondapi, Sajith Raghunandanan, Sivasankar Devanarayanan, Raghavan Varadarajan, Akhila Bommakanti
Publikováno v:
The FEBS Journal. 285:3849-3869
We characterize Rv0474, a putative transcriptional regulatory protein of Mycobacterium tuberculosis, which is found to function as a copper-responsive transcriptional regulator at toxic levels of copper. It is an autorepressor, but at elevated levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2774be7ae3da423b4f7e9a5818f8fd68
https://doi.org/10.1111/febs.14637
https://doi.org/10.1111/febs.14637
Autor:
Ranjit Ramachandran, Syed G. Dastager, Vipin Mohan Dan, Ravi S. Lankalapalli, Sabu Thomas, Vellekkatt Jamsheena, Ramakrishnan Ajay Kumar, K. Santhosh Kumar, J. S. Vinodh, Balaji Muralikrishnan
Publikováno v:
RSC Advances. 7:36335-36339
Limited efficacy of the BCG (Bacillus Calmette–Guerin) vaccine against adult tuberculosis and the emergence of resistance to existing anti-tuberculosis drugs compel discovery of novel antibiotics against Mycobacterium tuberculosis. Actinomycetes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4835d65ef08f320ab72385748586dc65
https://doi.org/10.1039/c7ra05576e
https://doi.org/10.1039/c7ra05576e
Autor:
Ranjit Ramachandran, John B. Johnson, Sathish Mundayoor, Balaji Muralikrishnan, K Sivakumar, Ramakrishnan Ajay Kumar, Roshna Lawrence Gomez, Leny Jose, Sajith Raghunandanan
Publikováno v:
The FEBS Journal. 283:3056-3071
Rv3334 protein of Mycobacterium tuberculosis belongs to the MerR family of transcriptional regulators and is upregulated during hypoxia and other stress conditions. Employing GFP reporter constructs, mobility shift assays and ChIP assays, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43ff76488044190cd07e1fc0c928e9c
https://doi.org/10.1111/febs.13791
https://doi.org/10.1111/febs.13791
Autor:
Sajith Raghunandanan, Ramakrishnan Ajay Kumar, Raghu Bhagavat, Aneesh Chandran, Roshna Lawrence Gomez, Leny Jose, Sathish Mundayoor, Nagasuma Chandra, R.V. Omkumar, Ranjit Ramachandran
Publikováno v:
FEBS Journal. 283:265-281
We isolated an 8 kDa mycobacterial hypothetical protein, Rv3423.1, from the chromatin of human macrophages infected with Mycobacterium tuberculosis H37Rv. Bioinformatics predictions followed by in vitro biochemical assays with purified recombinant pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db8c93cedb8680513be067911d4e4e7
https://doi.org/10.1111/febs.13566
https://doi.org/10.1111/febs.13566
Autor:
Ranjit Ramachandran, Ramakrishnan Ajay Kumar, Vipin Gopinath, Akhil Raj Pushparajan, Arun Surendran, Sajith Raghunandanan, Sathish Mundayoor, Abdul Jaleel, Roshna Lawrence Gomez, Leny Jose
Publikováno v:
Molecular & Cellular Proteomics. 14:2160-2176
Tuberculosis, caused by Mycobacterium tuberculosis, still remains a major global health problem. The main obstacle in eradicating this disease is the ability of this pathogen to remain dormant in macrophages, and then reactivate later under immuno-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e44d2da6fc4decede60f91748a34ce
https://doi.org/10.1074/mcp.m115.051151
https://doi.org/10.1074/mcp.m115.051151