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Akademický článek

Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen

Autor: Rebecca A. Risman, Heather A. Belcher, Ranjini K. Ramanujam, John W. Weisel, Nathan E. Hudson, Valerie Tutwiler

Publikováno v: Biomolecules, Vol 14, Iss 2, p 230 (2024)

Altered properties of fibrin clots have been associated with bleeding and thrombotic disorders, including hemophilia or trauma and heart attack or stroke. Clotting factors, such as thrombin and tissue factor, or blood plasma proteins, such as fibrino

Externí odkaz: https://doaj.org/article/9563f263497e4300a923da868198b32a

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Akademický článek

Neurovascular Relationships in AGEs-Based Models of Proliferative Diabetic Retinopathy

Autor: Juan S. Peña, Ranjini K. Ramanujam, Rebecca A. Risman, Valerie Tutwiler, Francois Berthiaume, Maribel Vazquez

Publikováno v: Bioengineering, Vol 11, Iss 1, p 63 (2024)

Diabetic retinopathy affects more than 100 million people worldwide and is projected to increase by 50% within 20 years. Increased blood glucose leads to the formation of advanced glycation end products (AGEs), which cause cellular and molecular dysf

Externí odkaz: https://doaj.org/article/b64835f9b4414ddb8631626693e8dab9

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Akademický článek

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Autor: Sachita Ganesa, Amrita Sule, Ranjini K. Sundaram, Ranjit S. Bindra

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT e

Externí odkaz: https://doaj.org/article/3be4e14900544a7f90d22c402aafdc1e

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Akademický článek

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

Autor: Jennifer Garbarino, Jillian Eckroate, Ranjini K. Sundaram, Ryan B. Jensen, Ranjit S. Bindra

Publikováno v: Translational Oncology, Vol 14, Iss 9, Pp 101147- (2021)

Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and represents a potential target for cancer therapies. ATRX is known to function as a histone chaperone that helps incorporate histone variant, H3.3, into

Externí odkaz: https://doaj.org/article/ec8c3ae6f6ca412bb672812d0fc589e5

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Akademický článek

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Autor: Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase ge

Externí odkaz: https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e

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Akademický článek

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Publikováno v: Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate

Externí odkaz: https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf

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