Výsledky vyhledávání - "Ranjini Iyengar"

Akademický článek

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.

Autor: Takeo Kuwata, Yoshiaki Nishimura, Sonya Whitted, Ilnour Ourmanov, Charles R Brown, Que Dang, Alicia Buckler-White, Ranjini Iyengar, Jason M Brenchley, Vanessa M Hirsch

Publikováno v: PLoS Pathogens, Vol 5, Iss 4, p e1000372 (2009)

The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. Whereas the acute phase of the infection is dominated by virus-mediated depletion

Externí odkaz: https://doaj.org/article/d1962e6ff9e24476927633e2aaa8c877

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Development of Neurological Disease Is Associated with Increased Immune Activation in Simian Immunodeficiency Virus-Infected Macaques

Autor: Jason M. Brenchley, Charles R. Brown, Ranjini Iyengar, Vanessa M. Hirsch, Alicia Buckler-White, Robert M. Goeken, Sonya Whitted, Ronald J. Plishka, Bernard A. P. Lafont, Que Dang, Kenta Matsuda, Matthew F. Starost

Publikováno v: Journal of Virology. 86:13795-13799

Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e7aecb3fe70d63f622e31f84247300
https://doi.org/10.1128/jvi.02174-12

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Degenerate Recognition of MHC Class I Molecules with Bw4 and Bw6 Motifs by a Killer Cell Ig-like Receptor 3DL Expressed by Macaque NK Cells

Autor: Ronald J. Plishka, Jamie Rossjohn, Dan Chen, Ranjini Iyengar, Andrew G. Brooks, Alicia Buckler-White, Bernard A. P. Lafont, Emma Gostick, David Price, Julian P. Vivian, Sebastien M. Maloveste, Robin L. Kruthers

Publikováno v: The Journal of Immunology. 189:4338-4348

The killer cell immunoglobulin-like receptors (KIRs) expressed on the surface of natural killer (NK) cells recognize specific major histocompatibility complex class I (MHC-I) molecules and regulate NK cell activities against pathogen-infected cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feb190f68fde8e42c783cdc670c3a57
https://doi.org/10.4049/jimmunol.1201360

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Sequential Evolution and Escape from Neutralization of Simian Immunodeficiency Virus SIVsmE660 Clones in Rhesus Macaques

Autor: Robert M. Goeken, Ilnour Ourmanov, Alicia Buckler-White, Vanessa M. Hirsch, Charles R. Brown, Ronald J. Plishka, Fan Wu, Scott T. Aoki, Takeo Kuwata, Ranjini Iyengar

Publikováno v: Journal of Virology. 86:8835-8847

Simian immunodeficiency virus (SIV) infection of rhesus macaques has become an important surrogate model for evaluating HIV vaccine strategies. The extreme resistance to neutralizing antibody (NAb) of many commonly used strains, such as SIVmac251/239

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8d852880781d74bc9a8e6b59db2b7a
https://doi.org/10.1128/jvi.00923-12

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Recombination-Mediated Changes in Coreceptor Usage Confer an Augmented Pathogenic Phenotype in a Nonhuman Primate Model of HIV-1-Induced AIDS

Autor: Tatsuhiko Igarashi, Reza Sadjadpour, Wendy Lee, Malcolm A. Martin, Ronald Willey, Alicia Buckler-White, Masashi Shingai, Yoshiaki Nishimura, Ranjini Iyengar, Olivia K. Donau, Jason M. Brenchley

Publikováno v: Journal of Virology. 85:10617-10626

Evolution of the env gene in transmitted R5-tropic human immunodeficiency virus type 1 (HIV-1) strains is the most widely accepted mechanism driving coreceptor switching. In some infected individuals, however, a shift in coreceptor utilization can oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870a7cb271f1611ed6e2fd3b8a28b35
https://doi.org/10.1128/jvi.05010-11

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Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content Is Able To Establish Infections in Pig-Tailed Macaques

Autor: Ranjini Iyengar, Robin L. Dewar, Akio Adachi, Alicia Buckler-White, Russel A. Byrum, H. Clifford Lane, Tatsuhiko Igarashi, Kazuya Kamada, Malcolm A. Martin, Charles E. Buckler

Publikováno v: Journal of Virology. 81:11549-11552

A human immunodeficiency virus type 1 (HIV-1) derivative (HIVNL-DT5R) containing sequences encoding a 7-amino-acid segment of CA and the entirevifgene from simian immunodeficiency virus (SIV) was previously shown to establish spreading infections in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3705778bcf858f10a7e3ad71ad5acb87
https://doi.org/10.1128/jvi.00960-07

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Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques

Autor: Ronald J. Plishka, Charles R. Brown, Alicia Buckler-White, Vanessa M. Hirsch, Robert M. Goeken, Ranjini Iyengar, Ilnour Ourmanov, Yanfang Zheng, Sonya Whitted

Publikováno v: Virology. 401(2)

Previous studies demonstrated that the nef gene is a critical determinant of the pathogenicity of simian immunodeficiency virus (SIV) in macaques. In the present study, we evaluated the effect of a spontaneous frameshift mutation in the C-terminus of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6401a5834ae594422b3bc3c9c83c084
https://pubmed.ncbi.nlm.nih.gov/20303562

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Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies

Autor: Ilnour Ourmanov, Vanessa M. Hirsch, Charles R. Brown, Yoshiaki Nishimura, Sonya Whitted, Alicia Buckler-White, Jason M. Brenchley, Ranjini Iyengar, Que Dang, Takeo Kuwata

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 5, Iss 4, p e1000372 (2009)

The progressive decline of CD4+ T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. Whereas the acute phase of the infection is dominated by virus-mediated depletion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eab40613817596212fbda02b8c1236
https://pubmed.ncbi.nlm.nih.gov/19360097

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Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques

Autor: Ranjini Iyengar, Theodore S. Theodore, Olivia K. Donau, Hiromi Imamichi, Charles E. Buckler, Yoshiaki Nishimura, Malcolm A. Martin, Tatsuhiko Igarashi, Alicia Buckler-White, Christopher Erb

Publikováno v: Journal of virology. 81(19)

Unlike prototypical lentiviruses like visna and caprine arthritis-encephalitis viruses, which are mainly macrophage tropic (M-tropic), primate lentiviruses primarily target CD4 + T lymphocytes. We previously reported that during the late phase of hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b64f211528b06af5f3edbdf172afbe
https://pubmed.ncbi.nlm.nih.gov/17626082

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A Rapid Progressor-Specific Variant Clone of Simian Immunodeficiency Virus Replicates Efficiently In Vivo Only in the Absence of Immune Reponses▿

Autor: Russell Byrum, Vanessa M. Hirsch, Takeo Kuwata, Sonya Whitted, Ronald J. Plishka, Ranjini Iyengar, Alicia Buckler-White, Robert M. Goeken

Rapid progression to disease is observed in patients infected with human immunodeficiency virus (HIV) (9, 13, 30, 38, 40, 60) and macaques experimentally infected with simian immunodeficiency virus (SIV) (15, 18, 21, 22, 24, 31, 44, 47, 52, 64). In b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a87b844e99c5a2e93dfc2a348e0d0b
https://europepmc.org/articles/PMC1951398/

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