Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ranjie Xu"'
Autor:
Ranjie Xu, Xiaoxi Li, Andrew J. Boreland, Anthony Posyton, Kelvin Kwan, Ronald P. Hart, Peng Jiang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Human microglia present unique features; therefore, chimeric mouse models can enhance modelling of human microglia response in health and disease. Here, the authors show that hiPSC-derived mature microglia developed in the mouse brain, retain their i
Externí odkaz:
https://doaj.org/article/263c025eeb5a4353bd524f6f00f63e13
Autor:
Hyosung Kim, Ranjie Xu, Ragunathan Padmashri, Anna Dunaevsky, Ying Liu, Cheryl F. Dreyfus, Peng Jiang
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 890-905 (2019)
Summary: The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain. Here we report oligodendrogenesis in forebrai
Externí odkaz:
https://doaj.org/article/241818fa296d41cf9c4c06f2339510a5
Autor:
Le Wang, Vincent R. Mirabella, Rujia Dai, Xiao Su, Ranjie Xu, Azadeh Jadali, Matteo Bernabucci, Ishnoor Singh, Yu Chen, Jianghua Tian, Peng Jiang, Kevin Y. Kwan, ChangHui Pak, Chunyu Liu, Davide Comoletti, Ronald P. Hart, Chao Chen, Thomas C. Südhof, Zhiping P. Pang
Publikováno v:
Molecular Psychiatry.
Mutations in many synaptic genes are associated with autism spectrum disorders (ASDs), suggesting that synaptic dysfunction is a key driver of ASD pathogenesis. Among these mutations, the R451C-substitution in the NLGN3 gene that encodes the postsyna
Autor:
Colm Atkins, Xiaoxi Li, Ranjie Xu, Zhiping P. Pang, Caroline Erickson, Brian P. Daniels, Andrew J. Boreland, Mengmeng Jin, Peng Jiang
Publikováno v:
Stem Cell Reports
Summary Microglia play critical roles in brain development, homeostasis, and disease. Microglia in animal models cannot accurately model human microglia due to notable transcriptomic and functional differences between human and other animal microglia
Autor:
Anthony Posyton, Kelvin Y. Kwan, Ronald P. Hart, Peng Jiang, Andrew J. Boreland, Xiaoxi Li, Ranjie Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is larg
Publikováno v:
Cell Stem Cell
Summary Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture an
Autor:
Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C. Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y. Kwan, Zhiping P. Pang, Elizabeth Head, Ying Liu, Ronald P. Hart, Peng Jiang
Publikováno v:
Cell Stem Cell. 29:1135-1153.e8
Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down syndrome (DS) is the most common genetic developmental disorder and risk factor for AD. Surprisingly, little information is available on the impact of trisomy of
Autor:
Mengmeng Jin, Ranjie Xu, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Le Wang, Alessandra C. Martini, Matteo Bernabucci, Ping Xie, Kelvin Kwan, Zhiping P. Pang, Ying Liu, Elizabeth Head, Ronald P. Hart, Peng Jiang
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Journal of Materials Chemistry B. 5:3870-3878
Human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) are considered as a promising cell source for transplantation and have been used for organoid fabrication to recapitulate central nervous system (CNS) diseases in vitro.
Autor:
Anna Dunaevsky, Ragunathan Padmashri, Peng Jiang, Cheryl F. Dreyfus, Hyosung Kim, Ying Liu, Ranjie Xu
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 890-905 (2019)
Summary: The process of oligodendrogenesis has been relatively well delineated in the rodent brain. However, it remains unknown whether analogous developmental processes are manifested in the human brain. Here we report oligodendrogenesis in forebrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6ff5a2dfa28af5acae591f9bdd5d9b
https://europepmc.org/articles/PMC6524754/
https://europepmc.org/articles/PMC6524754/