Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ranjeet P. Dash"'
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Figure 2: JHU395 DON delivery to P493B lymphoma cells and in vivo time-dependent pharmacokinetics of JHU395 in CD-1 mouse plasma and jejunum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c47935fca6a68c490e97489c8e1ab3
https://doi.org/10.1158/1535-7163.22506901
https://doi.org/10.1158/1535-7163.22506901
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Figure 3: Ex vivo JHU395 vs vehicle treated tumor histological analyses and plasma glutamine from non-tumored mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b968395430a2aa0e1d155e583395089
https://doi.org/10.1158/1535-7163.22506895.v1
https://doi.org/10.1158/1535-7163.22506895.v1
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Figure 5: 13C5-glutamine in vivo flux analysis in vehicle vs JHU395 treated tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512207bc497be52fb47e003709121ee2
https://doi.org/10.1158/1535-7163.22506889
https://doi.org/10.1158/1535-7163.22506889
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Table 1: List of significantly affected metabolites identified in volcano plot following JHU395 versus vehicle treatment of flank MPNST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a554cb4db02f910f56a409eb76e569d
https://doi.org/10.1158/1535-7163.22506886.v1
https://doi.org/10.1158/1535-7163.22506886.v1
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
The carbon and nitrogen components of glutamine are used for multiple biosynthetic processes by tumors. Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac95f4d2ec2810d9f4a6ef32503fc9a5
https://doi.org/10.1158/1535-7163.c.6538519.v1
https://doi.org/10.1158/1535-7163.c.6538519.v1
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Figure 1: JHU395 and DON treatment of sNF02.2 MPNST cells, evaluation of PARP cleavage following JHU395 treatment in sNF96.2 cells, and effects of DON and JHU395 on oxygen consumption rates in sNF96.2 MPNST cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fbba17163016cce74a4f071dc2bf44
https://doi.org/10.1158/1535-7163.22506904.v1
https://doi.org/10.1158/1535-7163.22506904.v1
Autor:
Barbara S. Slusher, Rana Rais, Jaishri O. Blakeley, Pavel Majer, Cory Brayton, Michael T. Nedelcovych, Chabely Rodriguez, Lukáš Tenora, Jenny Lam, Ranjeet P. Dash, Joanna Marie H. Aguilar, Jesse Alt, Vijayabhaskar Veeravalli, Ying Wu, Liang Zhao, Kathryn M. Lemberg
Supplemental Figure 4: Weight changes in non-tumored NPcis mice over one month of daily JHU395 dosing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0719348eaeaea6afd5021b3ef1761ed8
https://doi.org/10.1158/1535-7163.22506892.v1
https://doi.org/10.1158/1535-7163.22506892.v1
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1 (2018)
Number of drugs with different mechanisms of actions is undergoing clinical trials for non-alcoholic steatohepatitis (NASH). Given the complexity of the disease with respect to pathophysiology in the liver and associated changes in the renal function
Externí odkaz:
https://doaj.org/article/65ffe87523c54eeb9a75c01b415b0840
Autor:
Rana Rais, Kathryn M. Lemberg, Lukáš Tenora, Matthew L. Arwood, Arindom Pal, Jesse Alt, Ying Wu, Jenny Lam, Joanna Marie H. Aguilar, Liang Zhao, Diane E. Peters, Carolyn Tallon, Rajeev Pandey, Ajit G. Thomas, Ranjeet P. Dash, Tanguy Seiwert, Pavel Majer, Robert D. Leone, Jonathan D. Powell, Barbara S. Slusher
Publikováno v:
Science advances. 8(46)
6-Diazo-5-oxo- l -norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON showed promising efficacy in clinical trials; however, its development was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f07fb35c5ea7c8da0c169f4eebf5b9
https://pubmed.ncbi.nlm.nih.gov/36383674
https://pubmed.ncbi.nlm.nih.gov/36383674
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 2, Pp 151-160 (2014)
Intranasal drug administration is receiving increased attention as a delivery method for bypassing the blood–brain barrier and rapidly targeting therapeutics to the CNS. However, rapid mucociliary clearance in the nasal cavity is a major hurdle. Th
Externí odkaz:
https://doaj.org/article/bd197387ebca485194204260ef979412