Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ranjay, Jayadev"'
Autor:
Kieop Park, Ranjay Jayadev, Sara G Payne, Isabel W Kenny-Ganzert, Qiuyi Chi, Daniel S Costa, William Ramos-Lewis, Siddharthan B Thendral, David R Sherwood
Publikováno v:
eLife, Vol 12 (2023)
Separate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withstand independent tissue movement. Yet, how cel
Externí odkaz:
https://doaj.org/article/5e5db74a213b4415b17418b13699a45d
Autor:
Claire A. Gianakas, Daniel P. Keeley, William Ramos-Lewis, Kieop Park, Ranjay Jayadev, Isabel W. Kenny, Qiuyi Chi, David R. Sherwood
Publikováno v:
Journal of Cell Biology. 222
Basement membrane (BM) matrices surround and separate most tissues. However, through poorly understood mechanisms, BMs of adjacent tissue can also stably link to support organ structure and function. Using endogenous knock-in fluorescent proteins, co
Autor:
Ranjay, Jayadev, Mychel R P T, Morais, Jamie M, Ellingford, Sandhya, Srinivasan, Richard W, Naylor, Craig, Lawless, Anna S, Li, Jack F, Ingham, Eric, Hastie, Qiuyi, Chi, Maryline, Fresquet, Nikki-Maria, Koudis, Huw B, Thomas, Raymond T, O'Keefe, Emily, Williams, Antony, Adamson, Helen M, Stuart, Siddharth, Banka, Damian, Smedley, David R, Sherwood, Rachel, Lennon
Publikováno v:
Genomics England Research Consortium 2022, ' A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations ', Science Advances, vol. 8, no. 20, eabn2265 . https://doi.org/10.1126/sciadv.abn2265
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 222 human
SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.
Autor:
Meghan A Morrissey, Ranjay Jayadev, Ginger R Miley, Catherine A Blebea, Qiuyi Chi, Shinji Ihara, David R Sherwood
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005905 (2016)
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell
Externí odkaz:
https://doaj.org/article/acc6c9883f994a33b3a930937db516a6
Autor:
Lauren L Lohmer, Matthew R Clay, Kaleb M Naegeli, Qiuyi Chi, Joshua W Ziel, Elliott J Hagedorn, Jieun E Park, Ranjay Jayadev, David R Sherwood
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005786 (2016)
Invadopodia are specialized membrane protrusions composed of F-actin, actin regulators, signaling proteins, and a dynamically trafficked invadopodial membrane that drive cell invasion through basement membrane (BM) barriers in development and cancer.
Externí odkaz:
https://doaj.org/article/f44cb6e4aa5b4ce4bcd0920fecf8f975
Autor:
Claire A. Gianakas, Daniel P. Keeley, William Ramos-Lewis, Kieop Park, Ranjay Jayadev, Qiuyi Chi, David R. Sherwood
Basement membrane (BM) matrices surround and separate most tissues. However, through poorly understood mechanisms, BMs of adjacent tissues can also stably link to support organ structure and function. Using endogenous knock-in fluorescent proteins, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d42e70c0a8ddd3fb895d47d9bbcd08
https://doi.org/10.1101/2021.12.21.473673
https://doi.org/10.1101/2021.12.21.473673
Autor:
Nikki-Maria Koudis, Damian Smedley, Mychel Rpt Morais, Jamie M Ellingford, Antony Adamson, David R. Sherwood, Maryline Fresquet, Anna S. Li, Sandhya Srinivasan, Eric Hastie, Ranjay Jayadev, Richard W. Naylor, Rachel Lennon, Emily Williams, Raymond T. O'Keefe, Jack F. Ingham, Helen M. Stuart, Craig Lawless, Huw B. Thomas, Qiuyi Chi, Siddharth Banka
SummaryBasement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5abdb5d7cef4df1add0326719cc4136c
https://doi.org/10.1101/2021.10.25.465762
https://doi.org/10.1101/2021.10.25.465762
Autor:
Ranjay Jayadev, David Sherwood
Publikováno v:
Current Biology. 27:R207-R211
Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they
Publikováno v:
The Journal of Cell Biology
Precise levels of collagen IV dictate the mechanical and signaling functions of basement membranes (BMs), but how collagen is incorporated into BMs in vivo is unclear. Jayadev et al. identify distinct integrin-based mechanisms controlling BM collagen
Autor:
Ranjay Jayadev, David R. Sherwood
Publikováno v:
eLife
How organ-shaping mechanical imbalances are generated is a central question of morphogenesis, with existing paradigms focusing on asymmetric force generation within cells. We show here that organs can be sculpted instead by patterning anisotropic res