Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ranjani Reddy"'
Publikováno v:
Chemosphere. 25:975-978
The effects of polychlorinated dibenzofurans (PCDFs) on hepatic I-compound DNA adducts in female Sprague-Dawley rats were determined at 2 dose levels. In the first experiments, rats (4 per group) were treated with each of 3 polychlorinated dibenzofur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81614c6a8843f8922110fd4f34e05d3c
https://doi.org/10.1016/0045-6535(92)90094-8
https://doi.org/10.1016/0045-6535(92)90094-8
Publikováno v:
Endocrinology. 129:3093-3100
DNA of all tissues studied thus far in untreated mammals contains as yet structurally unidentified, covalent modifications termed I (indigenous)-compounds, which are detectable by the 32P postlabeling assay for DNA adducts and increase with age. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808f05f80389c2076ad9624e0f6d49f
https://doi.org/10.1210/endo-129-6-3093
https://doi.org/10.1210/endo-129-6-3093
Autor:
Erika Randerath, Pei-Fang Yang, Tracy F. Danna, William P. Watson, Ranjani Reddy, Kurt Randerath
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 250:135-144
Oxygen free radicals, such as the hydroxyl radical generated by interaction of Fe2+ and H2O2 (Fenton reaction), are produced in mammalian cells as a result of aerobic metabolism and under various pathological conditions and are known to elicit mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afc20c48048cd599724c3b122487dda
https://doi.org/10.1016/0027-5107(91)90169-o
https://doi.org/10.1016/0027-5107(91)90169-o
Autor:
Tracy F. Danna, M. Sambasiva Rao, Ranjani Reddy, Kurt Randerath, Janardan K. Reddy, Erika Randerath
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 247:65-76
The mechanisms of the hepatocarcinogenicity of non-mutagenic peroxisome proliferators, i.e. compounds used as hypolipidemic drugs and industrial plasticizers, are not sufficiently understood. To gain more information on the mechanism of their action,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256cd8802676925bc61adb1fd435279d
https://doi.org/10.1016/0027-5107(91)90034-l
https://doi.org/10.1016/0027-5107(91)90034-l
Publikováno v:
Chemico-biological interactions. 88(2-3)
Previous work indicated that covalent age-dependent DNA modifications of endogenous origin termed I-compounds may represent useful biomarkers for tumor promotion/carcinogenesis, as various tumor promoters/carcinogens, including 2,3,7,8-tetrachlorodib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c52fd563222c03c0ca4e68ccc1b62ce
https://pubmed.ncbi.nlm.nih.gov/8403078
https://pubmed.ncbi.nlm.nih.gov/8403078
Autor:
Ranjani Reddy, Guo-Dong Zhou, Erika Randerath, Ronald W. Hart, Kurt Randerath, Tracy F. Danna
Publikováno v:
Mutation research. 295(1)
Caloric restriction (CR), known to extend median and maximum life spans, improve resistance to carcinogenesis, and significantly retard age-associated degenerative diseases in rodents, was previously reported to modulate levels of indigenous, age-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e8dceb141b4b67002af42ede9fb70c
https://pubmed.ncbi.nlm.nih.gov/7677927
https://pubmed.ncbi.nlm.nih.gov/7677927
Autor:
Anthony E. Crane, Kurt Randerath, Tracy F. Danna, Erika Randerath, William P. Watson, Ranjani Reddy
Publikováno v:
Mutation research. 275(3-6)
Oxygen free radicals generated by the interaction of Fe2+ and H2O2 (Fenton reaction) are capable of reacting with DNA bases, which may induce premutagenic and precarcinogenic lesions. Products formed in DNA by such reactions have been characterized a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178fae73f6b06baa51f94d4be36d34f
https://pubmed.ncbi.nlm.nih.gov/1383776
https://pubmed.ncbi.nlm.nih.gov/1383776
Autor:
Tracy F. Danna, Kurt Randerath, Ranjani Reddy, Erika Randerath, Ronald W. Hart, Angelo Turturro
Publikováno v:
Mechanisms of ageing and development. 58(2-3)
Rodent tissues display species-, strain-, sex- and tissue-specific adduct-like DNA modifications termed I-compounds, which increase with age, are modulated by diet and are presumably derived from indigenous metabolic intermediates. We have explored w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c031563955a73afe343107995c1c24
https://pubmed.ncbi.nlm.nih.gov/1875735
https://pubmed.ncbi.nlm.nih.gov/1875735