Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Ranjan Dutta"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating, immensely complex neurodegenerative disease by lack of effective treatments. We developed a network medicine methodology via integrating human brain multi-omics data to prioritize drug ta
Externí odkaz:
https://doaj.org/article/5c2c7a5d865c4837b4a0266377e13533
Autor:
Ajay Kumar, Brahmjot Singh, Kapil Paul, Palak Bakshi, Payal Bajaj, Manoj Kumar, Sukhvinder Dhiman, Shivam Jasrotia, Parveen Kumar, Ranjan Dutta
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract Background Cancer is a persistent global health challenge, demanding continuous exploration of innovative therapeutic strategies. Hydroxytyrosol (HT), derived from olive oil, has garnered attention for its potent antioxidant and anti-inflamm
Externí odkaz:
https://doaj.org/article/882f3a4f192a4868a5dd895ecada4ca1
Autor:
Debjit Khan, Iyappan Ramachandiran, Kommireddy Vasu, Arnab China, Krishnendu Khan, Fabio Cumbo, Dalia Halawani, Fulvia Terenzi, Isaac Zin, Briana Long, Gregory Costain, Susan Blaser, Amanda Carnevale, Valentin Gogonea, Ranjan Dutta, Daniel Blankenberg, Grace Yoon, Paul L. Fox
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Hypomyelinating leukodystrophy (HLD) is an autosomal recessive disorder characterized by defective central nervous system myelination. Exome sequencing of two siblings with severe cognitive and motor impairment and progressive hypomyelinatio
Externí odkaz:
https://doaj.org/article/3f6584a19f4b41cfbb1ed508918c473a
Autor:
Darshana Poddar, Nikhil Sharma, Tomoaki Ogino, Xu Qi, Patricia M. Kessler, Hiran Mendries, Ranjan Dutta, Ganes C. Sen
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The interferon (IFN) system protects mammals from diseases caused by virus infections. IFN synthesis is induced by pattern recognition receptor signaling pathways activated by virus infection. IFN is secreted from the infected cells and acts
Externí odkaz:
https://doaj.org/article/f38230ffa2eb43bfbd81376250bad105
Autor:
Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta, Jessica L. Williams
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and significantly contribute to pathol
Externí odkaz:
https://doaj.org/article/99257ce4b7c44071a83771f4345e0463
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 6, Pp 1279-1291 (2021)
Abstract Objective Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Though MS was initially considered to be a white matter demyelinating disease, myelin loss in cortical gra
Externí odkaz:
https://doaj.org/article/11095f45d2394675a0584372e911441e
Autor:
Yasuyuki Kihara, Yunjiao Zhu, Deepa Jonnalagadda, William Romanow, Carter Palmer, Benjamin Siddoway, Richard Rivera, Ranjan Dutta, Bruce D. Trapp, Jerold Chun
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS) that is associated
Externí odkaz:
https://doaj.org/article/253d48ea8e324c959cd159fe3faa35e5
Autor:
Selva Baltan, Safdar S. Jawaid, Anthony M. Chomyk, Grahame J. Kidd, Jacqueline Chen, Harsha D. Battapady, Ricky Chan, Ranjan Dutta, Bruce D. Trapp
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Cognitive dysfunction occurs in greater than 50% of individuals with multiple sclerosis (MS). Hippocampal demyelination is a prominent feature of postmortem MS brains and hippocampal atrophy correlates with cognitive decline in MS patients.
Externí odkaz:
https://doaj.org/article/b680dd10db08431a81269324a9403942
Autor:
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.
Externí odkaz:
https://doaj.org/article/8405f74419104281af9993328f364b19
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, where ongoing demyelination and remyelination failure are the major factors for progressive neurological disability. In this report, we employe
Externí odkaz:
https://doaj.org/article/278515b7bc654155a6bdb2078aa11247