Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ranillo R.G. Resuello"'
Autor:
Tetsuhiro Kajikawa, Ruel A. Briones, Ranillo R.G. Resuello, Joel V. Tuplano, Edimara S. Reis, Evlambia Hajishengallis, Cristina A.G. Garcia, Despina Yancopoulou, John D. Lambris, George Hajishengallis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 207-215 (2017)
Periodontitis is a chronic inflammatory disease associated with overactivation of the complement system. Recent preclinical studies suggest that host-modulation therapies may contribute to effective treatment of human periodontitis, which may lead to
Externí odkaz:
https://doaj.org/article/22d55fa3c5d54a8ebc9836dd935b8ccf
Autor:
Bo Nilsson, Felix Hönes, David A. C. Messerer, Martijn van Griensven, Rebecca Halbgebauer, Stephanie Denk, Sebastian Hafner, Christian Karl Braun, Daniel Ricklin, Peter Radermacher, Ranillo R.G. Resuello, Joel V. Tuplano, Markus Huber-Lang, Benjamin Mayer, Edimara S. Reis, John D. Lambris, Kristina Nilsson, Anke Schultze, Alexandra Primikyri, Sofia Koutsogiannaki, Ali-Reza Biglarnia
Publikováno v:
Shock, 51(1), 78-87. LIPPINCOTT WILLIAMS & WILKINS
Trauma-induced hemorrhagic shock (HS) plays a decisive role in the development of immune, coagulation, and organ dysfunction often resulting in a poor clinical outcome. Imbalanced complement activation is intricately associated with the molecular dan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925f6ab68c5b15fd0600bfc8005ff28
https://doi.org/10.1097/SHK.0000000000001127
https://doi.org/10.1097/SHK.0000000000001127
Autor:
Edimara S. Reis, Ranillo R.G. Resuello, Tchilabalo Dilezitoko Alayi, Joel V. Tuplano, John D. Lambris, Nadja Berger
Publikováno v:
Journal of Medicinal Chemistry. 61:6153-6162
Improper regulation of complement is associated with various pathologies, and the clinical demand for compounds that can regulate complement activation is therefore imperative. Cp40, an analog of the peptide compstatin, inhibits all complement pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f3abc28c8b2439543f9a121c524021
https://doi.org/10.1021/acs.jmedchem.8b00560
https://doi.org/10.1021/acs.jmedchem.8b00560
Autor:
Ruel A. Briones, George Hajishengallis, Edimara S. Reis, Ranillo R.G. Resuello, John D. Lambris, Joel V. Tuplano, Cristina A.G. Garcia, Tetsuhiro Kajikawa, Evlambia Hajishengallis, Despina Yancopoulou
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 207-215 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 207-215 (2017)
Periodontitis is a chronic inflammatory disease associated with overactivation of the complement system. Recent preclinical studies suggest that host-modulation therapies may contribute to effective treatment of human periodontitis, which may lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ebbcee716ca1fb7e7120ddda9ee195
https://doi.org/10.1016/j.omtm.2017.08.001
https://doi.org/10.1016/j.omtm.2017.08.001
Autor:
Tomoki Maekawa, Xiaofei Li, Kai Bao, Ruel A. Briones, Cristina A.G. Garcia, Edimara S. Reis, Ranillo R.G. Resuello, Nagihan Bostanci, Joel V. Tuplano, John D. Lambris, Christian Panse, Jonas Grossmann, George Hajishengallis
BACKGROUND AND AIM: Periodontitis is a prevalent chronic inflammatory disease associated with dysbiosis. Although complement inhibition has been successfully used to treat periodontitis in animal models, studies globally analysing inflamed tissue pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597cf93aaf4c1a95fe7cf461696f5635
https://www.zora.uzh.ch/id/eprint/162412/
https://www.zora.uzh.ch/id/eprint/162412/
Autor:
Anthony J. Young, Xin Wang, John D. Lambris, Robert K. Doot, Alice F. Tarantal, David L. Kukis, Edimara S. Reis, Despina Yancopoulou, Nadja Berger, Tetsuhiro Kajikawa, Athena M. Soulika, Dimitrios C. Mastellos, George Hajishengallis, Ranillo R.G. Resuello, Bo Nilsson, Ali Reza Biglarnia, Sophia Koutsogiannaki, Justin T. Gumas, Joel V. Tuplano, Periklis G. Foukas, Markus Huber-Lang
The central component of the complement cascade, C3, is involved in various biological functions, including opsonization of foreign bodies, clearance of waste material, activation of immune cells, and triggering of pathways controlling development. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91837f81fa50edf839efa9faf0ffb86
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373239
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373239
Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters
Autor:
John D. Lambris, Hui Chen, Ranillo R.G. Resuello, Edimara S. Reis, Daniel Ricklin, Robert A. DeAngelis
Publikováno v:
Immunobiology. 220:476-482
Approximately 350,000 individuals in the United States rely on maintenance hemodialysis treatment because of end-stage renal disease. Despite improvements in dialysis technology, the mortality rate for patients treated with maintenance dialysis is st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0592ea1b20c2f89cc609c4e0b2e3d3
https://doi.org/10.1016/j.imbio.2014.10.026
https://doi.org/10.1016/j.imbio.2014.10.026
Autor:
Daniel Ricklin, John D. Lambris, Alexandra Primikyri, Ranillo R.G. Resuello, Bo Nilsson, Malvina Papanastasiou, Sophia Koutsogiannaki, Joel V. Tuplano, Edimara S. Reis, Yiannis Sarigiannis
Cp40 is a 14-amino acid cyclic analog of the peptidic complement inhibitor compstatin that binds with sub-nanomolar affinity to complement component C3 and has already shown promise in various models of complement-related diseases. The preclinical an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba5abae69b614b7172bf25258fe7e00
https://europepmc.org/articles/PMC5241290/
https://europepmc.org/articles/PMC5241290/
Autor:
Hongyu Qiu, Guy M. Genin, Stephen F. Vatner, Zhe Sun, Jerome P. Trzeciakowski, Christophe Depre, Filipinas F. Natividad, Yi Zhu, Elliot L. Elson, Gerald A. Meininger, Meredith Gansner, William C. Hunter, Dorothy E. Vatner, Ranillo R.G. Resuello
Publikováno v:
Circulation Research. 107:615-619
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55bc01330fa12c013181aaa9009465aa
https://doi.org/10.1161/circresaha.110.221846
https://doi.org/10.1161/circresaha.110.221846
Autor:
Misun Park, Guy R. Heyndrickx, Vinciane Gaussin, Jozef Bartunek, Ranillo R.G. Resuello, Dorothy E. Vatner, Stephen F. Vatner, You-Tang Shen, Filipinas F. Natividad, Richard N. Kitsis
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H785-H791
The goal of this investigation was to determine the distribution of myocardial apoptosis in myocytes and nonmyocytes in primates and patients with heart failure (HF). Almost all clinical cardiologists and cardiovascular investigators believe that myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f264ed8c48a1e6208c83986520a79164
https://doi.org/10.1152/ajpheart.00310.2009
https://doi.org/10.1152/ajpheart.00310.2009