Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Rania El-Botty"'
Autor:
Rania El‐Botty, Sophie Vacher, Juliette Mainguené, Adrien Briaux, Sabrina Ibadioune, Ahmed Dahmani, Elodie Montaudon, Fariba Nemati, Léa Huguet, Laura Sourd, Ludivine Morriset, Sophie Château‐Joubert, Thierry Dubois, Virginie Maire, Rosette Lidereau, Audrey Rapinat, David Gentien, Florence Coussy, Ivan Bièche, Elisabetta Marangoni
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2017-2028 (2023)
Triple negative breast cancers (TNBCs) represent 15–20% of all breast cancers and are associated with higher recurrence and distant metastasis rate. Standard of care for early stage TNBC is anthracyclines combined with cyclophosphamide (AC) followe
Externí odkaz:
https://doaj.org/article/544d9d964bc94114b651429060007609
Autor:
Rania El-Botty, Ludivine Morriset, Elodie Montaudon, Zakia Tariq, Anne Schnitzler, Marina Bacci, Nicla Lorito, Laura Sourd, Léa Huguet, Ahmed Dahmani, Pierre Painsec, Heloise Derrien, Sophie Vacher, Julien Masliah-Planchon, Virginie Raynal, Sylvain Baulande, Thibaut Larcher, Anne Vincent-Salomon, Guillaume Dutertre, Paul Cottu, Géraldine Gentric, Fatima Mechta-Grigoriou, Scott Hutton, Keltouma Driouch, Ivan Bièche, Andrea Morandi, Elisabetta Marangoni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients’ tumours, metastasis-de
Externí odkaz:
https://doaj.org/article/b26393ab46f442b18957dda9286c9e24
Autor:
Petra ter Brugge, Sarah C. Moser, Ivan Bièche, Petra Kristel, Sabrina Ibadioune, Alexandre Eeckhoutte, Roebi de Bruijn, Eline van der Burg, Catrin Lutz, Stefano Annunziato, Julian de Ruiter, Julien Masliah Planchon, Sophie Vacher, Laura Courtois, Rania El-Botty, Ahmed Dahmani, Elodie Montaudon, Ludivine Morisset, Laura Sourd, Léa Huguet, Heloise Derrien, Fariba Nemati, Sophie Chateau-Joubert, Thibaut Larcher, Anne Salomon, Didier Decaudin, Fabien Reyal, Florence Coussy, Tatiana Popova, Jelle Wesseling, Marc-Henri Stern, Jos Jonkers, Elisabetta Marangoni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Homologous recombination deficiency is linked with platinum-based chemotherapy response in triple-negative breast cancer (TNBC) but methods to clinically identify these patients are lacking. Here, using patient-derived xenografts of TNBC the authors
Externí odkaz:
https://doaj.org/article/45c67b1c1e0a4a2998d04e87b0b265a7
Autor:
Ivan Bièche, Florence Coussy, Rania El-Botty, Sophie Vacher, Sophie Château-Joubert, Ahmed Dahmani, Elodie Montaudon, Cécile Reyes, David Gentien, Fabien Reyal, Francesco Ricci, André Nicolas, Caterina Marchio, Anne Vincent-Salomon, Marick Laé, Elisabetta Marangoni
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Malignant adenomyoepithelioma (AME) of the breast is an exceptionally rare form of breast cancer, with a significant metastatic potential. Chemotherapy has been used in the management of advanced AME patients, however the majority of treatme
Externí odkaz:
https://doaj.org/article/e4264a632f1846d494cd0287d8ee7c44
Autor:
Elodie Montaudon, Joanna Nikitorowicz-Buniak, Laura Sourd, Ludivine Morisset, Rania El Botty, Léa Huguet, Ahmed Dahmani, Pierre Painsec, Fariba Nemati, Sophie Vacher, Walid Chemlali, Julien Masliah-Planchon, Sophie Château-Joubert, Camilla Rega, Mariana Ferreira Leal, Nikiana Simigdala, Sunil Pancholi, Ricardo Ribas, André Nicolas, Didier Meseure, Anne Vincent-Salomon, Cécile Reyes, Audrey Rapinat, David Gentien, Thibaut Larcher, Mylène Bohec, Sylvain Baulande, Virginie Bernard, Didier Decaudin, Florence Coussy, Muriel Le Romancer, Guillaume Dutertre, Zakia Tariq, Paul Cottu, Keltouma Driouch, Ivan Bièche, Lesley-Ann Martin, Elisabetta Marangoni
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Identifying novel therapies for the treatment of CDK4/6 inhibitor-resistant patients is of great importance. Here, the authors demonstrate that PLK1 inhibition is a potential therapeutic target in CCND1-driven and in RB-positive Palbociclib-resistant
Externí odkaz:
https://doaj.org/article/cbbadef41cb14a1b91639138a1f60fcb
Autor:
Fabien Reyal, Martine Piccart, Ivan Bièche, Sergio Roman-Roman, Didier Decaudin, Marick Lae, Anne Vincent-Salomon, Agnès Noel, Nor Eddine Sounni, Pierre Foidart, Audrey Rapinat, David Gentien, Sophie Vacher, Justine Fleury, Fariba Nemati, Elodie Montaudon, Ahmed Dahmani, Franck Assayag, Ludmilla de Plater, Jean-Luc Servely, Sophie Château-Joubert, Rania El-Botty, Florence Coussy, Cécile Laurent, Elisabetta Marangoni
List of genes differentially regulated between resistant and responder PDX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34239787458093aa4a253bb2ab2e7500
https://doi.org/10.1158/1078-0432.22470075.v1
https://doi.org/10.1158/1078-0432.22470075.v1
Autor:
Fabien Reyal, Martine Piccart, Ivan Bièche, Sergio Roman-Roman, Didier Decaudin, Marick Lae, Anne Vincent-Salomon, Agnès Noel, Nor Eddine Sounni, Pierre Foidart, Audrey Rapinat, David Gentien, Sophie Vacher, Justine Fleury, Fariba Nemati, Elodie Montaudon, Ahmed Dahmani, Franck Assayag, Ludmilla de Plater, Jean-Luc Servely, Sophie Château-Joubert, Rania El-Botty, Florence Coussy, Cécile Laurent, Elisabetta Marangoni
Purpose: Triple-negative breast cancer (TNBC) patients with residual disease after neoadjuvant chemotherapy have a poor outcome. We developed patient-derived xenografts (PDX) from residual tumors to identify efficient chemotherapies and predictive bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e973375fe05dffeef6b1cd0d284cf17
https://doi.org/10.1158/1078-0432.c.6527424
https://doi.org/10.1158/1078-0432.c.6527424
Autor:
Fabien Reyal, Martine Piccart, Ivan Bièche, Sergio Roman-Roman, Didier Decaudin, Marick Lae, Anne Vincent-Salomon, Agnès Noel, Nor Eddine Sounni, Pierre Foidart, Audrey Rapinat, David Gentien, Sophie Vacher, Justine Fleury, Fariba Nemati, Elodie Montaudon, Ahmed Dahmani, Franck Assayag, Ludmilla de Plater, Jean-Luc Servely, Sophie Château-Joubert, Rania El-Botty, Florence Coussy, Cécile Laurent, Elisabetta Marangoni
Boxplot of the expression of genes encoding proteins involved in capecitabine metabolism (TYMP, TYMS, TK1, DPYD) and cell-cycle control (RB1, CDKN2A, CCND1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4c2b5a7074dd9acac3071b6e5f0020
https://doi.org/10.1158/1078-0432.22470090.v1
https://doi.org/10.1158/1078-0432.22470090.v1
Autor:
Elisabetta Marangoni, Sergio Roman-Roman, Jean-Yves Pierga, Didier Decaudin, Jean-Jacques Fontaine, Jean-Luc Servely, Rana Hatem, Sophie Vacher, Vonick Sibut, Pierre de la Grange, David Gentien, Audrey Rapinat, Benoit Albaud, Thomas Bagarre, Aurélie Thuleau, Sophie Chateau-Joubert, Rania El Botty, Franck Assayag, Ivan Bièche, Paul Cottu
Purpose: Patients with luminal breast cancer (LBC) often become endocrine resistant over time. We investigated the molecular changes associated with acquired hormonoresistances in patient-derived xenografts of LBC.Experimental Design: Two LBC xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f90e4d70f184b6fca304cd4cd408b8
https://doi.org/10.1158/1078-0432.c.6523118
https://doi.org/10.1158/1078-0432.c.6523118
Autor:
Elisabetta Marangoni, Sergio Roman-Roman, Jean-Yves Pierga, Didier Decaudin, Jean-Jacques Fontaine, Jean-Luc Servely, Rana Hatem, Sophie Vacher, Vonick Sibut, Pierre de la Grange, David Gentien, Audrey Rapinat, Benoit Albaud, Thomas Bagarre, Aurélie Thuleau, Sophie Chateau-Joubert, Rania El Botty, Franck Assayag, Ivan Bièche, Paul Cottu
Supplementary Table S7. Upstream regulators identified by the Upstream Regulator Analysis in HBCx22 TamR and HBCx34 TamR xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bc996c00ded4a39ec8d9a2e82314d6
https://doi.org/10.1158/1078-0432.22455812.v1
https://doi.org/10.1158/1078-0432.22455812.v1