Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rani Zananiri"'
Autor:
Rani Zananiri, Sivasubramanyan Mangapuram Venkata, Vera Gaydar, Dan Yahalom, Omri Malik, Sergei Rudnizky, Oded Kleifeld, Ariel Kaplan, Arnon Henn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
RecBCD is a remarkably fast DNA helicase. Using a battery of biophysical methods, Zananiri et. al reveal additional, non-catalytic ATP binding sites that increase the ATP flux to the catalytic sites that allows fast unwinding when ATP is scarce.
Externí odkaz:
https://doaj.org/article/3abd36f307634b5ab5baa58a5b34d1af
Autor:
Rani Zananiri, Omri Malik, Sergei Rudnizky, Vera Gaydar, Roman Kreiserman, Arnon Henn, Ariel Kaplan
Publikováno v:
eLife, Vol 8 (2019)
The subunits of the bacterial RecBCD act in coordination, rapidly and processively unwinding DNA at the site of a double strand break. RecBCD is able to displace DNA-binding proteins, suggesting that it generates high forces, but the specific role of
Externí odkaz:
https://doaj.org/article/743f74ea77c247089857f091985b97db
Autor:
Rani Zananiri, Oded Kleifeld, Arnon Henn, Ariel Kaplan, Vera Gaydar, Sivasubramanyan Mangapuram Venkata
Publikováno v:
Biophysical Journal. 118:534a
Autor:
Arnon Henn, Roman Kreiserman, Sergei Rudnizky, Omri Malik, Vera Gaydar, Ariel Kaplan, Rani Zananiri
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The subunits of the bacterial RecBCD act in coordination, rapidly and processively unwinding DNA at the site of a double strand break. RecBCD is able to displace DNA-binding proteins, suggesting that it generates high forces, but the specific role of
RecBCD, responsible for the initiation of double stranded break repair in bacteria, is a processive DNA helicase with an unwinding rate approaching ∼1,600 bp·s−1. The mechanism enabling RecBCD to achieve such fast unwinding rate is not known. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaea72f34a5c1e182ce33467714a1b9f
https://doi.org/10.1101/210823
https://doi.org/10.1101/210823
Double-strand DNA breaks are the severest type of genomic damage, requiring rapid response to ensure survival. RecBCD helicase in prokaryotes initiates processive and rapid DNA unzipping essential for break repair. Yet, the energetics of RecBCD durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076473c95293396b1acb9846237259c2
https://doi.org/10.1101/190215
https://doi.org/10.1101/190215
Autor:
Rani Zananiri, Sivasubramanyan Mangapuram Venkata, Vera Gaydar, Dan Yahalom, Omri Malik, Sergei Rudnizky, Oded Kleifeld, Ariel Kaplan, Arnon Henn
Publikováno v:
Nature communications. 13(1)
The RecBCD helicase initiates double-stranded break repair in bacteria by processively unwinding DNA with a rate approaching ∼1,600 bp·s−1, but the mechanism enabling such a fast rate is unknown. Employing a wide range of methodologies — inclu
Autor:
Arnon Henn, Vera Gaydar, Rani Zananiri, Sivasubramanyan Mangapuram Venkata, Ariel Kaplan, Oded Kleifeld
Publikováno v:
Biophysical Journal. 116:490a