Výsledky vyhledávání

Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replicationin vivo

Autor: Malik Kahli, Duncan J. Smith, Rani Yeung, Joseph Osmundson

Publikováno v: Nucleic Acids Research

Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes place in the context of 5’ flap structures generated via strand-displacement synthesis by DNA polyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f47dfe86b9c5c554ce1cffcd37831c
https://doi.org/10.1093/nar/gky1242

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Determinants of Replication-Fork Pausing at tRNA Genes in Saccharomyces cerevisiae

Autor: Rani Yeung, Duncan J. Smith

Publikováno v: Genetics

Transfer RNA (tRNA) genes are widely studied sites of replication-fork pausing and genome instability in the budding yeast Saccharomyces cerevisiae. tRNAs are extremely highly transcribed and serve as constitutive condensin binding sites. tRNA transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8495b5a2604a132ab9f6fa5b1d66ab58
https://europepmc.org/articles/PMC7153945/

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The impediment to replication at tRNA genes in S. cerevisiae does not require tRNA transcription, and is facilitated by topoisomerases and Rad18-dependent repair pathways

Autor: Duncan J. Smith, Rani Yeung

tRNA genes are widely studied sites of replication-fork pausing and genome instability in the budding yeastSaccharomyces cerevisiae. tRNAs are extremely highly transcribed and serve as constitutive condensin binding sites. tRNA transcription by RNA p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135dcd2e2e3c8daec1cc6306683f839f

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Pif1-family helicases cooperate to suppress widespread replication fork arrest at tRNA genes

Autor: Duncan J. Smith, Joseph Osmundson, Jayashree Kumar, Rani Yeung

Saccharomyces cerevisiaeencodes two distinct Pif1-family helicases – Pif1 and Rrm3 – which have been reported to play distinct roles in numerous nuclear processes. Here, we systematically characterize the roles of Pif1 helicases in replisome prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cce3077165f1ae7ed4da8bda3d96d4
https://doi.org/10.1101/082008

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Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes

Autor: Joseph Osmundson, Jayashree Kumar, Rani Yeung, Duncan J. Smith

Publikováno v: Nature structural & molecular biology

Saccharomyces cerevisiae encodes two distinct Pif1-family helicases – Pif1 and Rrm3 – which have been reported to play distinct roles in numerous nuclear processes. Here, we systematically characterize the roles of Pif1 helicases in replisome pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27458bee2bb5d89fd6fecb43de9eaf79
https://pubmed.ncbi.nlm.nih.gov/27991904

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Verification of the Combimatrix influenza detection assay for the detection of influenza A subtype during the 2007–2008 influenza season in Toronto, Canada

Autor: Ernesto Lombos, Joanne Blair, Shelly Bolotin, A. Eshaghi, Rani Yeung, Steven J. Drews

Publikováno v: Virology Journal, Vol 6, Iss 1, p 37 (2009)
Virology Journal

The increase in adamantine resistance in influenza A (H3N2) and the emergence of oseltamivir resistance in influenza A (H1N1) has necessitated the use of rapid methodologies to detect influenza subtype. The purpose of this study was to evaluate the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ad955aa82564ff55ef7d7be8bff704
https://doi.org/10.1186/1743-422x-6-37

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Characterization of culture-positive adenovirus serotypes from respiratory specimens in Toronto, Ontario, Canada: September 2007-June 2008

Autor: Ernesto Lombos, Steven J. Drews, Alireza Eshaghi, Rani Yeung, Joanne Blair, Laura Burton, Tony Mazzulli

Publikováno v: Virology Journal, Vol 6, Iss 1, p 11 (2009)
Virology Journal

This study describes the prevalence of culture-positive adenovirus serotypes in culture-positive respiratory specimens sent to the Central Public Health Laboratory, Toronto, Ontario, Canada for the period September 2007–June 2008. Total nucleic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a24f0e2b0875a6c8fda66e4a22b854

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