Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rani K. Powers"'
Autor:
Alexandra J. Lee, Dallas L. Mould, Jake Crawford, Dongbo Hu, Rani K. Powers, Georgia Doing, James C. Costello, Deborah A. Hogan, Casey S. Greene
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 5, Pp 912-927 (2022)
Genome-wide transcriptome profiling identifies genes that are prone to differential expression (DE) across contexts, as well as genes with changes specific to the experimental manipulation. Distinguishing genes that are specifically changed in a cont
Externí odkaz:
https://doaj.org/article/23d39b95a13b4a23a60211c9d4fe3a5c
Autor:
Haiqing Bai, Longlong Si, Amanda Jiang, Chaitra Belgur, Yunhao Zhai, Roberto Plebani, Crystal Yuri Oh, Melissa Rodas, Aditya Patil, Atiq Nurani, Sarah E. Gilpin, Rani K. Powers, Girija Goyal, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mechanical forces in lungs facilitate breathing motions. Here the authors use a microfluidic human lung alveolus chip to study influenza infection and find that mechanical forces from active chips also induce innate inflammatory responses via, at lea
Externí odkaz:
https://doaj.org/article/a8197b35fe0e4313b281435e947641eb
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Publikováno v:
Mathematical and Computational Applications, Vol 26, Iss 2, p 40 (2021)
Integrating gene-level data is useful for predicting the role of genes in biological processes. This problem has typically focused on supervised classification, which requires large training sets of positive and negative examples. However, training d
Externí odkaz:
https://doaj.org/article/f5ff1288fff2408ca294074f36b51fee
Autor:
Crystal Yuri Oh, Ilona Golynker, Sarah E. Gilpin, Haiqing Bai, Rachelle Prantil-Baun, Amanda Jiang, Danni Y. Zhu, Steven P. Gygi, Mercy Soong, Melissa Rodas, Marisa McGrath, Longlong Si, Robert Haupt, Seongmin Kim, James Logue, Daniel Blanco-Melo, Tristan X. Jordan, Randy A. Albrecht, Rasmus Møller, Tian Zhang, Donald E. Ingber, Kohei Oishi, Justin J. Frere, Kambez H. Benam, Daisy A. Hoagland, Girija Goyal, Kenneth E. Carlson, Wen-Chun Liu, Rani K. Powers, Shu Horiuchi, Benjamin E. Nilsson-Payant, Skyler Uhl, Roberto Plebani, Matthew B. Frieman, Benjamin R. tenOever, Stuart Weston, Atiq Nurani, Wuji Cao
Publikováno v:
Nature biomedical engineering
The rapid repurposing of antivirals is particularly pressing during pandemics. However, rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines that do not recapitulate human physiology at the tissue and organ lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a3db572711b44bb7347a5c830b55e9
https://doi.org/10.1038/s41551-021-00718-9
https://doi.org/10.1038/s41551-021-00718-9
Autor:
Megan M. Sperry, Tomiko Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K. Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E. Carlson, Ronald J. Wong, Idit Kosti, Brian L. Le, James Logue, Holly Hammond, Matthew Frieman, David K. Stevenson, Donald E. Ingber, Marina Sirota, Richard Novak
Publikováno v:
medRxiv
PLoS computational biology, vol 19, iss 5
PLoS computational biology, vol 19, iss 5
SummaryImportanceDrug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30e7c259c82c34fff7c6971e0274968
https://pubmed.ncbi.nlm.nih.gov/35441166
https://pubmed.ncbi.nlm.nih.gov/35441166
Autor:
Amir Bein, Cicely W. Fadel, Ben Swenor, Wuji Cao, Rani K. Powers, Diogo M. Camacho, Arash Naziripour, Andrew Parsons, Nina LoGrande, Sanjay Sharma, Seongmin Kim, Sasan Jalili-Firoozinezhad, Jennifer Grant, David T. Breault, Junaid Iqbal, Asad Ali, Lee A. Denson, Sean R. Moore, Rachelle Prantil-Baun, Girija Goyal, Donald E. Ingber
Publikováno v:
Nature biomedical engineering. 6(11)
Environmental enteric dysfunction (EED)—a chronic inflammatory condition of the intestine—is characterized by villus blunting, compromised intestinal barrier function and reduced nutrient absorption. Here we show that essential genotypic and phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec786b77c43536950cefa09ece33081e
https://pubmed.ncbi.nlm.nih.gov/35739419
https://pubmed.ncbi.nlm.nih.gov/35739419
Autor:
Longlong Si, Haiqing Bai, Crystal Yuri Oh, Tian Zhang, Fan Hong, Amanda Jiang, Yongxin Ye, Tristan X. Jordan, James Logue, Marisa McGrath, Chaitra Belgur, Atiq Nurani, Wuji Cao, Rachelle Prantil-Baun, Steven P Gygi, Rani K. Powers, Matthew Frieman, Benjamin R. tenOever, Donald E. Ingber
Publikováno v:
bioRxiv : the preprint server for biology.
The current COVID-19 pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and type III interferon (IFN-I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8713a3c24de12dba4103cc3c760507d
https://pubmed.ncbi.nlm.nih.gov/36032397
https://pubmed.ncbi.nlm.nih.gov/36032397
Autor:
Amir Bein, Cicely W. Fadel, David T. Breault, Sasan Jalili Firoozinezhad, Sanjay Sharma, Sean R. Moore, Diogo M. Camacho, Arash Naziripour, Ben Swenor, Rachelle Prantil-Baun, Andrew W Parsons, Girija Goyal, Rani K. Powers, Asad Ali, Junaid Iqbal, Nina LoGrande, Lee A. Denson, Jennifer Grant, Seongmin Kim, Wuji Cao, Donald E. Ingber
Environmental Enteric Dysfunction (EED) is a chronic inflammatory condition of the intestine characterized by villus blunting, compromised intestinal barrier function, and reduced nutrient absorption. Here, we show that key genotypic and phenotypic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7155bc36cfc8881294a95a62c0f97b0e
https://doi.org/10.1101/2021.10.11.21264722
https://doi.org/10.1101/2021.10.11.21264722
Autor:
Andrew M. Ravanelli, Yuying Wang, Rani K. Powers, Christina A. Kearns, Jacob H. Hines, Bruce Appel, Maranda J. Donaldson
Publikováno v:
Developmental Biology. 444:93-106
SUMMARYDuring development of the central nervous system oligodendrocyte precursor cells (OPCs) give rise to both myelinating oligodendrocytes and NG2 glia, which are the most proliferative cells in the adult mammalian brain. NG2 glia retain character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa123d332eba6cb5ed0a899169636fa8
https://doi.org/10.1016/j.ydbio.2018.10.004
https://doi.org/10.1016/j.ydbio.2018.10.004