Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Rani E George"'
Autor:
Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Immunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL. We aimed to tackle one of the most notable
Externí odkaz:
https://doaj.org/article/7142ba69053342a98bcc3622acf2b968
Autor:
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Sara Kochanny, Rachel Terhaar, Casey J. Mehrhoff, Kritika Patel, Jacob Brewer, Benjamin Kusswurm, Arlene Naranjo, Hiroyuki Shimada, Nicole A. Cipriani, Aliya N. Husain, Peter Pytel, Elizabeth A. Sokol, Susan L. Cohn, Rani E. George, Alexander T. Pearson, Mark A. Applebaum
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained
Externí odkaz:
https://doaj.org/article/3ee6eb5342a14a0d87b21a668f03f699
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003533 (2013)
Heterozygous germline mutations and deletions in PHOX2B, a key regulator of autonomic neuron development, predispose to neuroblastoma, a tumor of the peripheral sympathetic nervous system. To gain insight into the oncogenic mechanisms engaged by thes
Externí odkaz:
https://doaj.org/article/455d346e2d2b449b98bf32b2a6571a5d
Autor:
Rani E George, Edward F Attiyeh, Shuli Li, Lisa A Moreau, Donna Neuberg, Cheng Li, Edward A Fox, Matthew Meyerson, Lisa Diller, Paolo Fortina, A Thomas Look, John M Maris
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e255 (2007)
Neuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss of heterozygosity (LOH) and DNA copy numb
Externí odkaz:
https://doaj.org/article/5a8b57bc42164cfa9f7e9f15eb369f48
Autor:
Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Peizhe Ren, Ryan Borchert, Varsha Gupta, Chang Ye, Ruiqi Ge, Zhongyu Zhu, Mallory Brodnik, Yuhao Zhong, Kelley Moore, Helen Salwen, Rani E. George, Malgorzata Krajewska, Alexandre Chlenski, Mark A. Applebaum, Chuan He, Susan L. Cohn
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114165- (2024)
Summary: The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14). High levels
Externí odkaz:
https://doaj.org/article/b70135c60c274c8db78ac7b2b49f0621
Autor:
Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries, Bandana Sharma, Alyssa Kennedy, John A. Porco, Jr., Rani E. George
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114134- (2024)
Summary: Tumor MYCN amplification is seen in high-risk neuroblastoma, yet direct targeting of this oncogenic transcription factor has been challenging. Here, we take advantage of the dependence of MYCN-amplified neuroblastoma cells on increased prote
Externí odkaz:
https://doaj.org/article/c27456a402fc45b2a3efce99ad4f2e45
Autor:
Satyaki Sengupta, Sanjukta Das, Angela C. Crespo, Annelisa M. Cornel, Anand G. Patel, Navin R. Mahadevan, Marco Campisi, Alaa K. Ali, Bandana Sharma, Jared H. Rowe, Hao Huang, David N. Debruyne, Esther D. Cerda, Malgorzata Krajewska, Ruben Dries, Minyue Chen, Shupei Zhang, Luigi Soriano, Malkiel A. Cohen, Rogier Versteeg, Rudolf Jaenisch, Stefani Spranger, Rizwan Romee, Brian C. Miller, David A. Barbie, Stefan Nierkens, Michael A. Dyer, Judy Lieberman, Rani E. George
Publikováno v:
Nat Cancer
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited success due to immune evasion mechanisms, coupled with an incomplete understanding of predictors of response. Here, from bulk and single-cell transcriptomic analyses, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3cd72b8a276f1ae1150701f612b648
https://doi.org/10.1038/s43018-022-00427-5
https://doi.org/10.1038/s43018-022-00427-5
Autor:
Rani E. George, A. Thomas Look, John M. Maris, C. Patrick Reynolds, Edward F. Attiyeh, Shuli Li, Cheng Li, Samuel L. Volchenboum
Supplementary Figure 2 from Comparison of Primary Neuroblastoma Tumors and Derivative Early-Passage Cell Lines Using Genome-Wide Single Nucleotide Polymorphism Array Analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57d199f85f45e5cae0c42b14bdfb33
https://doi.org/10.1158/0008-5472.22378379
https://doi.org/10.1158/0008-5472.22378379
Autor:
David R. Kaplan, Carol J. Thiele, Meredith S. Irwin, Freda D. Miller, Herman Yeger, A. Thomas Look, Kristen M. Smith, Paul S. Thorner, J. Ted Gerstle, Rani E. George, Libo Zhang, Amy E. McKee, Loen M. Hansford
Supplementary Table 2 from Neuroblastoma Cells Isolated from Bone Marrow Metastases Contain a Naturally Enriched Tumor-Initiating Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004d1ef34733a1b8656ea9d5115bdc6b
https://doi.org/10.1158/0008-5472.22370471.v1
https://doi.org/10.1158/0008-5472.22370471.v1
Autor:
Rani E. George, A. Thomas Look, John M. Maris, C. Patrick Reynolds, Edward F. Attiyeh, Shuli Li, Cheng Li, Samuel L. Volchenboum
Supplementary Figure 1 from Comparison of Primary Neuroblastoma Tumors and Derivative Early-Passage Cell Lines Using Genome-Wide Single Nucleotide Polymorphism Array Analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74015ab1252c5c4231e3081ef3d91c26
https://doi.org/10.1158/0008-5472.22378382
https://doi.org/10.1158/0008-5472.22378382