Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Autor: Lyczek, Agatha, Berger, Benedict-Tilman, Rangwala, Aziz M., Paung, YiTing, Tom, Jessica, Philipose, Hannah, Guo, Jiaye, Albanese, Steven K., Robers, Matthew B., Knapp, Stefan, Chodera, John D., Seeliger, Markus A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Nov . 118(46), 1-10.

Externí odkaz: https://www.jstor.org/stable/27093907

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome.

Autor: Rangwala, Aziz M.¹ (AUTHOR) aziz.rangwala@stonybrookmedicine.edu, Mingione, Victoria R.¹ (AUTHOR), Georghiou, George¹ (AUTHOR) victoria.mingione@stonybrook.edu, Seeliger, Markus A.¹ (AUTHOR) aziz.rangwala@stonybrookmedicine.edu

Publikováno v: Biomolecules (2218-273X). May2022, Vol. 12 Issue 5, p685. 26p.

Resistance to kinase inhibition through shortened target engagement.

Autor: Rangwala, Aziz M.¹ (AUTHOR) Markus.Seeliger@stonybrook.edu, Berger, Benedict-Tilman^2,3 (AUTHOR), Robers, Matthew B.⁴ (AUTHOR), Knapp, Stefan^2,3 (AUTHOR), Seeliger, Markus A.¹ (AUTHOR) Aziz.Rangwala@stonybrookmedicine.edu

Publikováno v: Molecular & Cellular Oncology. 2022, Vol. 9 Issue 1, p1-3. 3p.

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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.

Autor: Leyte-Vidal A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA., DeFilippis R; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Outhwaite IR; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Kwan I; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lee JY; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Leavitt C; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Miller KB; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Rea D; Adult Hematology Department, Hôpital Saint-Louis, Paris, France., Rangwala AM; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lou K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA., Patel S; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Alvarez A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.; Department of Chemistry, University of California, Berkeley, CA, 94720, USA., Bahar I; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Seeliger MA; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Shah NP; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA. neil.shah@ucsf.edu.

Publikováno v: Leukemia [Leukemia] 2024 Sep; Vol. 38 (9), pp. 2046-2050. Date of Electronic Publication: 2024 Jul 31.