Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA

Autor: D'Agostino, Ilaria, Ardino, Claudia, Poli, Giulio, Sannio, Filomena, Lucidi, Massimiliano, Poggialini, Federica, Visaggio, Daniela, Rango, Enrico, Filippi, Silvia, Petricci, Elena, Visca, Paolo, Botta, Lorenzo, Docquier, Jean-Denis, Dreassi, Elena

Publikováno v: In European Journal of Medicinal Chemistry 5 March 2022 231

Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma.

Autor: Rango, Enrico^1,2 (AUTHOR), Di Maria, Salvatore^1,2 (AUTHOR), Zamperini, Claudio^2,3 (AUTHOR), Poggialini, Federica^1,2 (AUTHOR), Crespan, Emmanuele^2,4 (AUTHOR), Perini, Cecilia^2,4 (AUTHOR), Sabetta, Samantha^2,5 (AUTHOR), Saponara, Simona^2,6 (AUTHOR), Fusi, Fabio^1,2 (AUTHOR), Maga, Giovanni^2,4 (AUTHOR), Angelucci, Adriano^2,5 (AUTHOR), Gaudio, Eugenio^2,7,8 (AUTHOR), Berton, Francesco^2,7,8 (AUTHOR), Schenone, Silvia^2,9 (AUTHOR), Botta, Lorenzo^2,3,10 (AUTHOR) lor.botta83@gmail.com, Dreassi, Elena^1,2 (AUTHOR), Botta, Maurizio^1,2,10 (AUTHOR)

Publikováno v: Pharmaceutical Chemistry Journal. Mar2023, Vol. 56 Issue 12, p1616-1626. 11p.

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PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT

Autor: RANGO, ENRICO

The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c04aef68a1e2de1d7dec0a3f364bd5f
http://hdl.handle.net/11365/1140389

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