Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis.

Autor: Paula Giselle Czaikoski, José Maurício Segundo Correia Mota, Daniele Carvalho Nascimento, Fabiane Sônego, Fernanda Vargas e Silva Castanheira, Paulo Henrique Melo, Gabriela Trentin Scortegagna, Rangel Leal Silva, Romualdo Barroso-Sousa, Fabrício Oliveira Souto, Antonio Pazin-Filho, Florencio Figueiredo, José Carlos Alves-Filho, Fernando Queiróz Cunha

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148142 (2016)

Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial damage and take part in the pathogenesis of organ dysfunction in seve

Externí odkaz: https://doaj.org/article/9d63854b8ec5435ea7a3702eadfd87e3

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

Autor: Jing Wang, Henning Fröhlich, Felipe Bodaleo Torres, Rangel Leal Silva, Gernot Poschet, Amit Agarwal, Gudrun A. Rappold

Publikováno v: Proceedings of the National Academy of Sciences. 119

Significance FOXP1 haploinsufficiency underlies cognitive and motor impairments in individuals with FOXP1 syndrome. Here, we show that mice lacking one Foxp1 copy exhibit similar behavioral deficits, which may be caused by striatal dysfunction. Indee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3bb75c0e408badc087acfec810af1b
https://doi.org/10.1073/pnas.2112852119

Cinnamoyloxy-mammeisin, a coumarin from propolis of stingless bees, attenuates Th17 cell differentiation and autoimmune inflammation via STAT3 inhibition

Autor: Marcelo Franchin, Pedro Luiz Rosalen, Douglas da Silva Prado, Murilo César Paraluppi, Rangel Leal Silva, Luis Eduardo Alves Damasceno, David Fernando Colon Morelo, Marcelo Henrique Napimoga, Fernando Q. Cunha, José C. Alves-Filho, Thiago M. Cunha

Publikováno v: European Journal of Pharmacology. 929:175127

T helper 17 (Th17) lymphocytes play a critical role in the pathogenesis of autoimmune diseases, mainly by producing the pro-inflammatory cytokine interleukin-17 (IL-17). Therefore, Th17 lymphocytes have been considered a strategic target for drug dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b9083094da9bc9130e824968a58a7a
https://doi.org/10.1016/j.ejphar.2022.175127

Test of dissolution and comparison of in vitro dissolution profiles of coated ranitidine tablets marketed in Bahia, Brazil

Autor: Aníbal de Freitas Santos Júnior, Igor Santos Barbosa, Venyson Lima dos Santos, Rangel Leal Silva, Edimar Caetite Junior

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 50, Issue: 1, Pages: 83-89, Published: MAR 2014
Brazilian Journal of Pharmaceutical Sciences; Vol. 50 No. 1 (2014); 83-89
Brazilian Journal of Pharmaceutical Sciences; Vol. 50 Núm. 1 (2014); 83-89
Brazilian Journal of Pharmaceutical Sciences; v. 50 n. 1 (2014); 83-89
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

A ranitidina é um fármaco antissecretor, antagonista H2, usado no tratamento de desordens gástricas e duodenais. O teste de dissolução é utilizado para obter e comparar perfis de dissolução, estabelecendo semelhança de formas farmacêuticas.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bee770e2486f3260ca94d8c85f2853e
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100008&lng=en&tlng=en