Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rangel L Silva"'
A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity.
Autor:
Emília R Vaz, Patrícia T Fujimura, Galber R Araujo, Carlos A T da Silva, Rangel L Silva, Thiago M Cunha, Mônica Lopes-Ferreira, Carla Lima, Márcio J Ferreira, Jair P Cunha-Junior, Ernesto A Taketomi, Luiz R Goulart, Carlos Ueira-Vieira
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136116 (2015)
The transforming growth factor beta 1 (TGF-β1) is a pleiotropic cytokine with multiple roles in development, wound healing, and immune regulation. TGF-β1-mediated immune dysfunction may lead to pathological conditions, such as inflammation. Chronic
Externí odkaz:
https://doaj.org/article/83e2fa1e711a483f91c5af29c0de7e03
Autor:
Deysi V T Wong, Roberto C P Lima-Júnior, Cibele B M Carvalho, Vanessa F Borges, Carlos W S Wanderley, Amanda X C Bem, Caio A V G Leite, Maraiza A Teixeira, Gabriela L P Batista, Rangel L Silva, Thiago M Cunha, Gerly A C Brito, Paulo R C Almeida, Fernando Q Cunha, Ronaldo A Ribeiro
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139985 (2015)
Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL-1 and IL-18. These molecules and toll-like receptors (TLRs)
Externí odkaz:
https://doaj.org/article/70e4dd6593c243b0847fdb00138d362b
Autor:
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood. In this study, we foun
Externí odkaz:
https://doaj.org/article/c98ec044e03d4d9d88b85df1bc7f3f13
Autor:
Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin, Bernhard Ryffel, Thiago M. Cunha
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the molecular mechanisms of Cg-induced inflammation are not fully elucidated.
Externí odkaz:
https://doaj.org/article/fe56c29d443545788d694f1ed8880f87
Autor:
Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C. P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Silva Prado, Jose Carlos Alves-Filho, Claudio Medana, Geovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.
Externí odkaz:
https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd75
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 109-116 (2017)
Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is associated with plasticity of nociceptive pathway in which pain is prolonged even after healing of the injured tissue. Generally combinations of an
Externí odkaz:
https://doaj.org/article/022f9e1f86274826b113e014d74964a2
Autor:
Fernando Q. Cunha, Thiago M. Cunha, Roberto C. Lima-Junior, José C. Alves-Filho, José M. Mota, Cesar A. Speck-Hernandez, Rangel L. Silva, Cassia R. Silva, Camila M. Silva, Janaina A. Pereira, Caio A. Leite, Paula R. Viacava, Francisco F. Oliveira, João Paulo M. Luiz, David F. Colón, Carlos W. Wanderley
Supplementary material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38bcd3beb11f1dea5d8bf6ce2c7f0cf
https://doi.org/10.1158/0008-5472.22420176
https://doi.org/10.1158/0008-5472.22420176
Autor:
Fernando Q. Cunha, Thiago M. Cunha, Roberto C. Lima-Junior, José C. Alves-Filho, José M. Mota, Cesar A. Speck-Hernandez, Rangel L. Silva, Cassia R. Silva, Camila M. Silva, Janaina A. Pereira, Caio A. Leite, Paula R. Viacava, Francisco F. Oliveira, João Paulo M. Luiz, David F. Colón, Carlos W. Wanderley
Generation of myeloid cell-specific TLR4 knockout mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0526a5ad7dae7c0785ef09d9002c76c3
https://doi.org/10.1158/0008-5472.22420182.v1
https://doi.org/10.1158/0008-5472.22420182.v1
Autor:
Fernando Q. Cunha, Thiago M. Cunha, Roberto C. Lima-Junior, José C. Alves-Filho, José M. Mota, Cesar A. Speck-Hernandez, Rangel L. Silva, Cassia R. Silva, Camila M. Silva, Janaina A. Pereira, Caio A. Leite, Paula R. Viacava, Francisco F. Oliveira, João Paulo M. Luiz, David F. Colón, Carlos W. Wanderley
Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-cycle arrest. Here, we use several tumor models to show that pacli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14141477f0426e0754df79dec95c8a75
https://doi.org/10.1158/0008-5472.c.6510582.v1
https://doi.org/10.1158/0008-5472.c.6510582.v1
Autor:
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha
Publikováno v:
The Journal of clinical investigation. 132(23)
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood. In this study, we foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b766be7d6dc7837dfa31c2f198e1ca
https://pubmed.ncbi.nlm.nih.gov/36227694
https://pubmed.ncbi.nlm.nih.gov/36227694