Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ranganath Gopalakrishnan"'
Autor:
Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne A. J. Dubois, Ranganath Gopalakrishnan, Geraldine Masson, Nicola Della Ca’, Stefano Protti, Maurizio Fagnoni, Eli Zysman-Colman, Magnus Johansson, Timothy Noël
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs ea
Externí odkaz:
https://doaj.org/article/f268aa4aece843bb96f8b5b86625428c
Autor:
Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEA
Externí odkaz:
https://doaj.org/article/34105208594045348e3822ea97b488f7
Autor:
Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausch
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148608 (2016)
The aim of this study was to design, synthesize and validate a multifunctional antidepressant probe that is modified at two distinct positions. The purpose of these modifications was to allow covalent linkage of the probe to interaction partners, and
Externí odkaz:
https://doaj.org/article/c7800bb20b1a4b45897b23cc0a2bd9b8
Autor:
Stefan Geschwindner, Mercedes Vazquez-Chantada, Hacer Karatas, Carmen Carrillo García, Elisabetta Chiarparin, Dennis Schade, Malin Lemurell, Tom N. Grossmann, Paul R. J. Davey, Alleyn T. Plowright, Jeremy Kah Sheng Pang, Hélène Adihou, Boon Seng Soh, Stéphanie M. Guéret, Wanjin Hong, Carola M. Wassvik, Ranganath Gopalakrishnan, Eric Valeur, Tim Förster, Herbert Waldmann, Raphael Gasper, Ajaybabu V. Pobbati
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein–protein interactions (PPI). The chemical modulation of transcription factor acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a62c13a75607c3b0b4ec116b5e51b4
http://link.springer.com/article/10.1038/s41467-020-19224-8
http://link.springer.com/article/10.1038/s41467-020-19224-8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2355
Synthetic molecular probes have recently been in focus for their potential use in target deconvolution, target engagement studies, and imaging. With the field expanding, new strategies to develop such tools are in high demand. While traditional conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2d22cf45c5677dad97170bc7491ece5
https://pubmed.ncbi.nlm.nih.gov/34386948
https://pubmed.ncbi.nlm.nih.gov/34386948
Autor:
Ranganath Gopalakrishnan, Anaïs F. M. Noisier, Martin A. Hayes, Lara R. Malins, Magnus Johansson, William J. Drury, Eric Valeur, Laurent Knerr
Publikováno v:
Angewandte Chemie. 131:19272-19278
The late-stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide conjugation. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075503324188482e802a84db634108cb
https://doi.org/10.1002/ange.201910888
https://doi.org/10.1002/ange.201910888
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616161
Synthetic molecular probes have recently been in focus for their potential use in target deconvolution, target engagement studies, and imaging. With the field expanding, new strategies to develop such tools are in high demand. While traditional conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478da3f64a8c6ccc293dfa2b0ff57230
https://doi.org/10.1007/978-1-0716-1617-8_4
https://doi.org/10.1007/978-1-0716-1617-8_4
Autor:
Herbert Waldmann, Alleyn T. Plowright, Stéphanie M. Guéret, Tom N. Grossmann, Malin Lemurell, Eric Valeur, Ranganath Gopalakrishnan, Hélène Adihou
Publikováno v:
Angewandte Chemie. 129:10428-10459
Unsere sich stetig erweiternden Kenntnisse uber biologische Systeme haben eine Vielzahl an hoch interessanten neuen biologischen Zielstrukturen aufgedeckt, deren Modulation moglicherweise neuartige Therapiemoglichkeiten fur viele Krankheiten erschlie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d430335a34e2b44ff79399a9e65744
https://doi.org/10.1002/ange.201611914
https://doi.org/10.1002/ange.201611914
Autor:
Herbert Waldmann, Stéphanie M. Guéret, Tom N. Grossmann, Ranganath Gopalakrishnan, Malin Lemurell, Eric Valeur, Alleyn T. Plowright, Hélène Adihou
Publikováno v:
Valeur, E, Guéret, S M, Adihou, H, Gopalakrishnan, R, Lemurell, M, Waldmann, H, Grossmann, T N & Plowright, A T 2017, ' New Modalities for Challenging Targets in Drug Discovery ', Angewandte Chemie International Edition in English, vol. 56, no. 35, pp. 10294–10323 . https://doi.org/10.1002/anie.201611914
An ever increasing understanding of biological systems is providing a range of exciting novel biological targets whose modulation may enable novel therapeutic options in many diseases. These targets include protein-protein and protein-nucleic acid in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e4ea67a7c105336e8bd829f572354a
http://www.scopus.com/inward/record.url?scp=85021097647&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85021097647&partnerID=8YFLogxK