Zobrazeno 1 - 10
of 521
pro vyhledávání: '"Rangamani, Padmini"'
Understanding the mechanisms of interactions within cells, tissues, and organisms is crucial to driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating biological systems and revealing biochemical r
Externí odkaz:
http://arxiv.org/abs/2408.05395
Mathematical models are indispensable to the system biology toolkit for studying the structure and behavior of intracellular signaling networks. A common approach to modeling is to develop a system of equations that encode the known biology using app
Externí odkaz:
http://arxiv.org/abs/2406.11178
Autor:
Francis, Emmet A., Laughlin, Justin G., Dokken, Jørgen S., Finsberg, Henrik N. T., Lee, Christopher T., Rognes, Marie E., Rangamani, Padmini
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, particularl
Externí odkaz:
http://arxiv.org/abs/2405.15968
The formation of microparticles requires the bending of the plasma membrane away from the cytosol. The capcity of the cell membrane to form a microparticle, and the rate of membrane deformation, are controlled by multiple factors, including loss of l
Externí odkaz:
http://arxiv.org/abs/2402.07120
Autor:
Laughlin, Justin G., Dokken, Jørgen S., Finsberg, Henrik N. T., Francis, Emmet A., Lee, Christopher T., Rognes, Marie E., Rangamani, Padmini
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of intracellular subcompartments such as membrane-bound organelles. These
Externí odkaz:
http://arxiv.org/abs/2306.07368
The initiation of directional cell motion requires symmetry breaking that can happen both with or without external stimuli. During cell crawling, forces generated by the cytoskeleton and their transmission through mechanosensitive adhesions to the ex
Externí odkaz:
http://arxiv.org/abs/2306.00236
Autor:
Malingen, Sage, Rangamani, Padmini
The deformation of cellular membranes regulates trafficking processes, such as exocytosis and endocytosis. Classically, the Helfrich continuum model is used to characterize the forces and mechanical parameters that cells tune to accomplish membrane s
Externí odkaz:
http://arxiv.org/abs/2206.05307
Autor:
Mahapatra, Arijit, Rangamani, Padmini
Plasma membrane tubes are ubiquitous in cellular membranes and in the membranes of intracellular organelles. They play crucial roles in trafficking, ion transport, and cellular motility. The formation of plasma membrane tubes can be due to localized
Externí odkaz:
http://arxiv.org/abs/2206.03652
Publikováno v:
PLOS Computational Biology 18(10): e1010651 (2022)
Dynamical systems modeling, particularly via systems of ordinary differential equations, has been used to effectively capture the temporal behavior of different biochemical components in signal transduction networks. Despite the recent advances in ex
Externí odkaz:
http://arxiv.org/abs/2204.05415
Effective treatments that prevent or reduce drug relapse vulnerability should be developed to relieve the high burden of drug addiction to society. This will only be possible by enhancing the understanding of the molecular mechanisms underlying the n
Externí odkaz:
http://arxiv.org/abs/2201.01735