Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

Autor: Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga R. Krishnan, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk, the Mood Disorders Precision Medicine Consortium

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Serum samples (baseline, 12 weeks) were drawn from participants

Externí odkaz: https://doaj.org/article/30eb222b87c747c397003f3db5d1bac9

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Autor: Rima Kaddurah-Daouk, Siamak Mahmoudian Dehkordi, Boadie W. Dunlop, Brenda W.J.H. Penninx, Ranga R. Krishnan, Yuri Milaneschi, Gabi Kastenmüller, Matthias Arnold, A. John Rush

BackgroundAltered metabolism of acylcarnitines – transporting fatty acids to mitochondria – may link cellular energy dysfunction to depression. We examined the potential causal role of acylcarnitine metabolism in depression by leveraging genomics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996006831b1309a10a4f76afa9fe5032
https://doi.org/10.1101/2021.10.18.21265157

Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression

Autor: Boadie W. Dunlop, Lisa St. John-Williams, Michelle K. Skime, Gregory Louie, W. Edward Craighead, J. Will Thompson, Rima Kaddurah-Daouk, Mark A. Frye, Xianlin Han, Rebecca Baillie, Sudeepa Bhattacharyya, Siamak MahmoudianDehkordi, Richard M. Weinshilboum, A. John Rush, Matthias Arnold, Patricio Riva-Posse, Ahmed T. Ahmed, M. Arthur Moseley, William M. McDonald, Ranga R. Krishnan

Publikováno v: Translational psychiatry, vol 11, iss 1
Translational psychiatry, 11(1):153
The Mood Disorders Precision Medicine Consortium (MDPMC) 2021, ' Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression ', Translational psychiatry, vol. 11, no. 1, 153 . https://doi.org/10.1038/s41398-020-01097-6
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Transl. Psychiatry 11:153 (2021)

Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9754e2acca12abde3a737ae62b5471
https://escholarship.org/uc/item/9fc8043n

BCI Facilitates the Improvement of Cognitive Functions in Children and Elderly

Autor: Choon Guan Lim, Helen Juan Zhou, Ranga R. Krishnan, Daniel Fung, Cuntai Guan, Tih-Shih Lee

Publikováno v: 2020 8th International Winter Conference on Brain-Computer Interface (BCI).

Brain-Computer Interface (BCI) technology has been under exploration as an alternative approach to restore or enhance brain functions, possibly. One of the attempts is to use BCI to help improve human cognitive functions by leveraging on the BCI capa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5806487d9ce9b9adacaa94d79f655c9
https://doi.org/10.1109/bci48061.2020.9061625

Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment

Autor: Sudeepa Bhattacharyya, Boadie W. Dunlop, Siamak Mahmoudiandehkordi, Ahmed T. Ahmed, Gregory Louie, Mark A. Frye, Richard M. Weinshilboum, Ranga R. Krishnan, A. John Rush, Helen S. Mayberg, W. Edward Craighead, Rima Kaddurah-Daouk

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience

Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288fd9988ff099d7bfcc1ab455196e54
https://www.frontiersin.org/article/10.3389/fnins.2019.00926/full