Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Ranga R, Krishnan"'
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Akademický článek
Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
Autor: Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga R. Krishnan, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk, the Mood Disorders Precision Medicine Consortium
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract It is unknown whether indoles, metabolites of tryptophan that are derived entirely from bacterial metabolism in the gut, are associated with symptoms of depression and anxiety. Serum samples (baseline, 12 weeks) were drawn from participants
Externí odkaz: https://doaj.org/article/30eb222b87c747c397003f3db5d1bac9
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2
Akademický článek
Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment
Autor: Sudeepa Bhattacharyya, Boadie W. Dunlop, Siamak Mahmoudiandehkordi, Ahmed T. Ahmed, Gregory Louie, Mark A. Frye, Richard M. Weinshilboum, Ranga R. Krishnan, A. John Rush, Helen S. Mayberg, W. Edward Craighead, Rima Kaddurah-Daouk
Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)
Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to t
Externí odkaz: https://doaj.org/article/1d507e490bc94b759eac5e2877b632db
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3
Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression
Autor: Yuri Milaneschi, Matthias Arnold, Gabi Kastenmüller, Siamak Mahmoudian Dehkordi, Ranga R. Krishnan, Boadie W. Dunlop, A. John Rush, Brenda W.J.H. Penninx, Rima Kaddurah-Daouk
Publikováno v: Journal of Affective Disorders, 307, 254-263. Elsevier
Journal of Affective Disorders
Mood Disorders Precision Medicine Consortium (MDPMC) 2022, ' Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression ', Journal of Affective Disorders, vol. 307, pp. 254-263 . https://doi.org/10.1016/j.jad.2022.03.070
J. Affect. Disord. 307, 254-263 (2022)
Background: Altered metabolism of acylcarnitines – transporting fatty acids to mitochondria – may link cellular energy dysfunction to depression. We examined the potential causal role of acylcarnitine metabolism in depression by leveraging genomi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9843d3aee5e2f55de0f684c2af262825
https://research.vumc.nl/en/publications/560b082e-dd81-4727-9c2a-3f1caae202fa
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4
Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression
Autor: Rima Kaddurah-Daouk, Siamak Mahmoudian Dehkordi, Boadie W. Dunlop, Brenda W.J.H. Penninx, Ranga R. Krishnan, Yuri Milaneschi, Gabi Kastenmüller, Matthias Arnold, A. John Rush
BackgroundAltered metabolism of acylcarnitines – transporting fatty acids to mitochondria – may link cellular energy dysfunction to depression. We examined the potential causal role of acylcarnitine metabolism in depression by leveraging genomics
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996006831b1309a10a4f76afa9fe5032
https://doi.org/10.1101/2021.10.18.21265157
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5
Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients
Autor: Sudeepa Bhattacharyya, Ahmed T. Ahmed, Hongjie Zhu, A. John Rush, Duan Liu, Siamak MahmoudianDehkordi, Ranga R. Krishnan, Richard M. Weinshilboum, Drew Neavin, Mark A. Frye, Matthias Arnold, Gregory Louie, Liewei Wang, Chunqiao Luo, Boadie W. Dunlop, Rima Kaddurah-Daouk
Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-14 (2019)
Transl. Psychiatry 9:173 (2019)
Translational Psychiatry
Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a37a695ec6298acf02a46a9218ebbff
http://link.springer.com/article/10.1038/s41398-019-0507-5
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6
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression
Autor: Boadie W. Dunlop, Lisa St. John-Williams, Michelle K. Skime, Gregory Louie, W. Edward Craighead, J. Will Thompson, Rima Kaddurah-Daouk, Mark A. Frye, Xianlin Han, Rebecca Baillie, Sudeepa Bhattacharyya, Siamak MahmoudianDehkordi, Richard M. Weinshilboum, A. John Rush, Matthias Arnold, Patricio Riva-Posse, Ahmed T. Ahmed, M. Arthur Moseley, William M. McDonald, Ranga R. Krishnan
Publikováno v: Translational psychiatry, vol 11, iss 1
Translational psychiatry, 11(1):153
The Mood Disorders Precision Medicine Consortium (MDPMC) 2021, ' Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression ', Translational psychiatry, vol. 11, no. 1, 153 . https://doi.org/10.1038/s41398-020-01097-6
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Transl. Psychiatry 11:153 (2021)
Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9754e2acca12abde3a737ae62b5471
https://escholarship.org/uc/item/9fc8043n
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7
Akademický článek
Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway.
Autor: Hongjie Zhu, Mikhail B Bogdanov, Stephen H Boyle, Wayne Matson, Swati Sharma, Samantha Matson, Erik Churchill, Oliver Fiehn, John A Rush, Ranga R Krishnan, Eve Pickering, Marielle Delnomdedieu, Rima Kaddurah-Daouk, Pharmacometabolomics Research Network
Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68283 (2013)
Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to 4 weeks of treatment. The obj
Externí odkaz: https://doaj.org/article/24d5a64e84744557ad6a9850b6d11604
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9
BCI Facilitates the Improvement of Cognitive Functions in Children and Elderly
Autor: Choon Guan Lim, Helen Juan Zhou, Ranga R. Krishnan, Daniel Fung, Cuntai Guan, Tih-Shih Lee
Publikováno v: 2020 8th International Winter Conference on Brain-Computer Interface (BCI).
Brain-Computer Interface (BCI) technology has been under exploration as an alternative approach to restore or enhance brain functions, possibly. One of the attempts is to use BCI to help improve human cognitive functions by leveraging on the BCI capa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5806487d9ce9b9adacaa94d79f655c9
https://doi.org/10.1109/bci48061.2020.9061625
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10
Akademický článek
Hippocampus shape analysis and late-life depression.
Autor: Zheen Zhao, Warren D Taylor, Martin Styner, David C Steffens, K Ranga R Krishnan, James R MacFall
Publikováno v: PLoS ONE, Vol 3, Iss 3, p e1837 (2008)
Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have sh
Externí odkaz: https://doaj.org/article/e11f4565b09e44129ebdc6cb30a4c012
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