Výsledky vyhledávání - "Ranga, Godavarti"

A modular approach for the ultra-scale-down of depth filtration

Autor: Ranga Godavarti, Jonida Basha, Daniel LaCasse, Tarit Mukhopadhyay, John M. Frostad, Doug Millard, Aaron Noyes, Benjamin Huffman, Richard S. Wright, Nigel J. Titchener-Hooker, Jim Mullin, Khurram Sunasara, Robert Fahrner, Scott Cook

Publikováno v: Journal of Membrane Science. 496:199-210

Depth filtration is employed in the production of many biological products. Although high throughput process development is available for most purification operations, options for high throughput depth filtration are limited. In this report, we descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::559242a7c8fae4cf8c38b9cdff23acce
https://doi.org/10.1016/j.memsci.2015.07.010

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Nature of foulants and fouling mechanism in the Protein A MabSelect resin cycled in a monoclonal antibody purification process

Autor: Jeffrey R. Salm, Martin Joseph P, William F. Daniels, Judy Glynn, Ranga Godavarti, Shaojie Zhang, Christopher Gallo, Giorgio Carta

Publikováno v: Biotechnology and Bioengineering. 113:141-149

The composition and origin of foulants and their spatial distribution within the particles of the Protein A MabSelect resin cycled in a mAb purification process are determined using electron and confocal microscopy techniques with gold and fluorescen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1374e48bff2c27aeecd0f0c8a8d24c9
https://doi.org/10.1002/bit.25706

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Structural and functional characteristics of virgin and fouled Protein A MabSelect resin cycled in a monoclonal antibody purification process

Autor: Judy Glynn, Shaojie Zhang, Martin Joseph P, Christopher Gallo, Jeffrey R. Salm, Giorgio Carta, Ranga Godavarti, William F. Daniels, Kerui Xu

Publikováno v: Biotechnology and Bioengineering. 113:367-375

The structural and functional characteristics of the Protein A MabSelect resin are determined for a virgin sample and for samples removed from a column that had been operated in an antibody capture process which had shown losses in product recovery o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eccc7dfed053581e62ae1c1215c3b9d
https://doi.org/10.1002/bit.25708

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High throughput screening of particle conditioning operations: II. Evaluation of scale-up heuristics with prokaryotically expressed polysaccharide vaccines

Autor: Khurram Sunasara, Aaron Noyes, Nick Merchant, Nigel J. Titchener-Hooker, Ben Huffman, Ranga Godavarti, Jonathan Coffman, Tarit Mukhopadhyay, Alex Berrill

Publikováno v: Biotechnology and Bioengineering. 112:1568-1582

Multivalent polysaccharide conjugate vaccines are typically comprised of several different polysaccharides produced with distinct and complex production processes. Particle conditioning steps, such as precipitation and flocculation, may be used to ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6025f3db0b99aa165ce143d6fc03d3fb
https://doi.org/10.1002/bit.25580

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High throughput screening of particle conditioning operations: I. System design and method development

Autor: Ranga Godavarti, Nigel J. Titchener-Hooker, Jonathan Coffman, Khurram Sunasara, Ben Huffman, Aaron Noyes, Tarit Mukhopadhyay

Publikováno v: Biotechnology and Bioengineering. 112:1554-1567

The biotech industry is under increasing pressure to decrease both time to market and development costs. Simultaneously, regulators are expecting increased process understanding. High throughput process development (HTPD) employs small volumes, paral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27868907d8fbe6a01bf9b3618baba31f
https://doi.org/10.1002/bit.25575

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High throughput quantification of capsular polysaccharides for multivalent vaccines using precipitation with a cationic surfactant

Autor: Aaron Noyes, Austin W. Boesch, Tarit Mukhopadhyay, Nigel J. Titchener-Hooker, Ranga Godavarti, Jonathan Coffman

Publikováno v: Vaccine. 31(48):5659-5665

The increasing requirement for multivalent vaccines containing diverse capsular polysaccharides has created an unmet need for a fast and straightforward assay for polysaccharide titer. We describe a novel and robust assay for the quantitation of anio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1154b27c103260f19e25e795d53e315e

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A tandem laboratory scale protein purification process using Protein A affinity and anion exchange chromatography operated in a weak partitioning mode

Autor: Ranga Godavarti, Timothy Iskra, Michael Shamashkin, Jon Coffman

Publikováno v: Biotechnology and Bioengineering. 110:2655-2663

A significant consequence of scaling up production of high titer monoclonal antibody (mAb) processes in existing facilities is the generation of in-process pools that exceed the capacity of storage vessels. A semi-continuous downstream process where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cff0c30b015c557f7806d6e32c3f1ec
https://doi.org/10.1002/bit.24955

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Structural and performance characteristics of representative anion exchange resins used for weak partitioning chromatography

Autor: Ranga Godavarti, William F. Daniels, Shaojie Zhang, Jeffrey R. Salm, Tim Iskra, Christopher Gallo, Giorgio Carta

Publikováno v: Biotechnology progress. 33(2)

Weak partitioning chromatography (WPC) has been proposed for the purification of monoclonal antibodies using an anion exchange (AEX) resin to simultaneously remove both acidic and basic protein impurities. Despite potential advantages, the relationsh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eff500a6f718077f156ec9cb7b0776
https://pubmed.ncbi.nlm.nih.gov/27997072

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