Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rang, Xu"'
Autor:
Xi-ji Qin, Meng-meng Xu, Jia-jun Ye, Yi-wei Niu, Yu-rong Wu, Rang Xu, Fen Li, Qi-hua Fu, Sun Chen, Kun Sun, Yue-juan Xu
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-16 (2022)
Abstract Background Heterotaxy syndrome (HTX) is caused by aberrant left–right patterning early in embryonic development, which results in abnormal positioning and morphology of the thoracic and abdominal organs. Currently, genetic testing discerns
Externí odkaz:
https://doaj.org/article/bb8e900448224b3fb576e6638b25b69f
Autor:
Sijie Liu, Wei Wei, Pengcheng Wang, Chunjie Liu, Xuechao Jiang, Tingting Li, Fen Li, Yurong Wu, Sun Chen, Kun Sun, Rang Xu
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010530 (2022)
Defects in laterality pattern can result in abnormal positioning of the internal organs during the early stages of embryogenesis, as manifested in heterotaxy syndrome and situs inversus, while laterality defects account for 3~7% of all congenital hea
Externí odkaz:
https://doaj.org/article/a08c086518fd4853ae4d6445344b5d1c
Autor:
Liqing Zhao, Suqiu Huang, Wei Wei, Bingyao Zhang, Wenxiang Shi, Yongzhou Liang, Rang Xu, Yurong Wu
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by motile ciliary dysfunction and impaired ultrastructure. Despite numerous studies, the genetic basis for about 30% of PCD cases remains to be elucidated. Here, we present the
Externí odkaz:
https://doaj.org/article/f15a648ab5824a7e9007f5dd623db401
Autor:
Xuechao Jiang, Tingting Li, Sijie Liu, Qihua Fu, Fen Li, Sun Chen, Kun Sun, Rang Xu, Yuejuan Xu
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Background TBX1 (T-box transcription factor 1) is a major candidate gene that likely contributes to the etiology of velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS). Although the haploinsufficiency of TBX1 in both mice and humans res
Externí odkaz:
https://doaj.org/article/0b3a087497624863a7b0a9e234c04a19
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract Background Cardiac valvulogenesis is a highly conserved process among vertebrates and cause unidirectional flow of blood in the heart. It was precisely regulated by signal pathways such as VEGF, NOTCH, and WNT and transcriptional factors suc
Externí odkaz:
https://doaj.org/article/085fbba0ca914efc8c4aa2eeeb180f8f
Publikováno v:
Zoological Research; 2024, Vol. 45 Issue 3, p567-574, 8p
Autor:
Shaohai Fang, Jia Li, Yang Xiao, Minjung Lee, Lei Guo, Wei Han, Tingting Li, Matthew C. Hill, Tingting Hong, William Mo, Rang Xu, Ping Zhang, Fen Wang, Jiang Chang, Yubin Zhou, Deqiang Sun, James F. Martin, Yun Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that
Externí odkaz:
https://doaj.org/article/100780c789c64844afdc6a69f48c6de2
Autor:
Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu, Kun Sun
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negative regulator of the k
Externí odkaz:
https://doaj.org/article/bafec5435c1148a8ba158e94a09169d7
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart diseases; as a result, the
Externí odkaz:
https://doaj.org/article/5829d9e99530484eae3dc533de23a57d
Autor:
Xuan He, Shuangshuang Yang, Rui Zhang, Lina Hou, Jianrong Xu, Yaer Hu, Rang Xu, Hao Wang, Yongfang Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Current therapies for Parkinson’s disease (PD) only offer limited symptomatic alleviation but fail to hamper the progress of the disease. Thus, it is imperative to establish new approaches aiming at protecting or reversing neurodegeneration in PD.
Externí odkaz:
https://doaj.org/article/c280a2d7b5b84cddad2416a536b21ae3