Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ranen Aviner"'
Autor:
Ranen Aviner, Peter V Lidsky, Yinghong Xiao, Michel Tassetto, Damian Kim, Lichao Zhang, Patrick L McAlpine, Joshua Elias, Judith Frydman, Raul Andino
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011535 (2024)
A better mechanistic understanding of virus-host dependencies can help reveal vulnerabilities and identify opportunities for therapeutic intervention. Of particular interest are essential interactions that enable production of viral proteins, as thos
Externí odkaz:
https://doaj.org/article/4f949c539917425396f505f21d021d7c
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a genetic mutation in the huntingtin gene (HTT). Here, cryo electron tomography provides insights into the morphology of the cells derived from patients with HD and mouse mod
Externí odkaz:
https://doaj.org/article/27dd4928dbf643889186e8bd55e8a97e
Autor:
Ranen Aviner
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1074-1083 (2020)
Puromycin is a naturally occurring aminonucleoside antibiotic that inhibits protein synthesis by ribosome-catalyzed incorporation into the C-terminus of elongating nascent chains, blocking further extension and resulting in premature termination of t
Externí odkaz:
https://doaj.org/article/d9f894db0f3f4fdbb56782f8fb5534f8
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005554 (2015)
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest
Externí odkaz:
https://doaj.org/article/8f30bede9c914be589931b24c5aa099a
Autor:
Ranen Aviner, Ting-Ting Lee, Vincent B. Masto, Dan Gestaut, Kathy H. Li, Raul Andino, Judith Frydman
SummaryHuntington’s disease (HD) is a devastating neurodegenerative disorder caused by CAG trinucleotide repeat expansions encoding a polyglutamine (polyQ) tract in the Huntingtin (HTT) gene1. Although mutant HTT (mHTT) protein tends to aggregate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337519297c0865cbc0588545fc71647e
https://doi.org/10.1101/2022.05.04.490528
https://doi.org/10.1101/2022.05.04.490528
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313875dd4f14f417b710f2f394017c4
https://doi.org/10.1101/2022.03.26.485912
https://doi.org/10.1101/2022.03.26.485912
Autor:
Peter K. Jackson, Peter V. Lidsky, Ranen Aviner, Dale Talbot, Gilad Doitsh, Weihao Zheng, Weiheng Su, Sara Capponi, Elia Brodsky, Leonid Brodsky, Raul Andino, Chien-Ting Wu, Robert Nakamura, Yuta Shirogane, Judith Frydman, Adam Catching, Weiyi Li, Arabinda Nayak, Yinghong Xiao, Joel D. Ernst, Simone Bianco, Elsa Rousseau, Colby E. Gekko
Publikováno v:
Cell, vol 184, iss 25
Summary RNA viruses generate defective viral genomes (DVG) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10580689b8609c812f9c903a99feb401
https://pubmed.ncbi.nlm.nih.gov/35590140
https://pubmed.ncbi.nlm.nih.gov/35590140
Publikováno v:
Nature
Nature, vol 596, iss 7873
Nature, vol 596, iss 7873
Viral pathogens are an ongoing threat to public health worldwide. Analysing their dependence on host biosynthetic pathways could lead to effective antiviral therapies1. Here we integrate proteomic analyses of polysomes with functional genomics and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4d8b568038f286c5b1df9ffc40686b
https://pubmed.ncbi.nlm.nih.gov/34675396
https://pubmed.ncbi.nlm.nih.gov/34675396
Publikováno v:
Nature. 599:E3-E3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c12c8ad1a340be517d57fa607061a0c
https://doi.org/10.1038/s41586-021-04102-0
https://doi.org/10.1038/s41586-021-04102-0
Autor:
Ranen Aviner, Judith Frydman
Publikováno v:
Cold Spring Harb Perspect Biol
Viruses are obligate intracellular parasites that rely on their hosts for protein synthesis, genome replication, and viral particle production. As such, they have evolved mechanisms to divert host resources, including molecular chaperones, facilitate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e436ea5dc9135f90c896097a8f25b5
https://pubmed.ncbi.nlm.nih.gov/30858229
https://pubmed.ncbi.nlm.nih.gov/30858229