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New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.

Autor: Zhu HY; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. Electronic address: hughzhu@hotmail.com., Desai J; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Cooper AB; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Wang J; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Rane DF; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Kirschmeier P; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Strickland C; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Liu M; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Nomeir AA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA., Girijavallabhan VM; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Feb 15; Vol. 24 (4), pp. 1228-31. Date of Electronic Publication: 2014 Jan 02.

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.

Autor: Njoroge FG; Department of Chemistry, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA., Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1997 Dec 19; Vol. 40 (26), pp. 4290-301.

Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency.

Autor: Lovey RG; Schering-Plough Research Institute, Bloomfield, New Jersey 07003., Elliott AJ, Kaminski JJ, Loebenberg D, Parmegiani RM, Rane DF, Girijavallabhan VM, Pike RE, Guzik H, Antonacci B, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1992 Oct 30; Vol. 35 (22), pp. 4221-9.

Synthesis and antifungal properties of dihydrobenzothiophene azoles.

Autor: Rane DF; Schering Corporation, Bloomfield, New Jersey 07003., Desai JA, Loebenberg D, Parmegiani R, Pike RE

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 1988; Vol. 544, pp. 105-8.