Výsledky vyhledávání

In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease

Autor: Erin McNulty, Randy Xun, Nathaniel D. Denkers, Amy V. Nalls, Candace K. Mathiason, Edward A. Hoover

Publikováno v: J Gen Virol

Infectivity associated with prion disease has been demonstrated in blood throughout the course of disease, yet the ability to detect blood-borne prions by in vitro methods remains challenging. We capitalized on longitudinal pathogenesis studies of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32f697a07c5daa3e2b5a7381d89a6dd
https://europepmc.org/articles/PMC7416609/

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KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia

Autor: Feng Yang, James Pickel, Daniel Akuma, Randy Xun, Jingshan Chen, Peixiong Yuan, Francesco Papaleo, Gregory V. Carr, Omoye Akhile, Paul Glineburg, James C. Barrow, Grace Y Zhang, Audrey Bebensee, Qingjun Tian, Ming Ren, Jing Du, Daniel R. Weinberger

Publikováno v: Molecular psychiatry

Overexpression in humans of KCNH2-3.1, which encodes a primate-specific and brain-selective isoform of the human ether-a-go-go-related (hERG) potassium channel, is associated with impaired cognition, inefficient neural processing, and schizophrenia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730da1274bd7d64324ff37dab82004e1
https://doi.org/10.1038/mp.2015.219

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Maintenance Role of a Glutathionyl-Hydroquinone Lyase (PcpF) in Pentachlorophenol Degradation by Sphingobium chlorophenolicum ATCC 39723

Autor: Guanjun Chen, Yan Huang, Luying Xun, Randy Xun

Publikováno v: Journal of Bacteriology. 190:7595-7600

Pentachlorophenol (PCP) is a toxic pollutant. Its biodegradation has been extensively studied in Sphingobium chlorophenolicum ATCC 39723. All enzymes required to convert PCP to a common metabolic intermediate before entering the tricarboxylic acid cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551a803fa35186e46e45303a7d346091
https://doi.org/10.1128/jb.00489-08

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Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels

Autor: Lincoln S. Smith, Atsushi Doi, Henner Koch, Sebastien Zanella, Gina E. Elsen, Robert F. Hevner, Jan-Marino Ramirez, Sarah Kirsch, Christopher M. Gomez, Randy Xun, Aguan D. Wei, Alfredo J. Garcia

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(8)

P/Q-type voltage-gated calcium channels (Cav2.1) play critical presynaptic and postsynaptic roles throughout the nervous system and have been implicated in a variety of neurological disorders. Here we report that mice with a genetic ablation of the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36db64d8576311a2af724f5615b12c49
https://pubmed.ncbi.nlm.nih.gov/23426690

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S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases

Autor: Randy Xun, Philip G. Board, Emiliano J. Sanchez, Luying Xun, Yan Huang, Sara M. Belchik, Huina Zhou, ChulHee Kang

Publikováno v: The Biochemical journal. 428(3)

Sphingobium chlorophenolicum completely mineralizes PCP (pentachlorophenol). Two GSTs (glutathione transferases), PcpC and PcpF, are involved in the degradation. PcpC uses GSH to reduce TeCH (tetrachloro-p-hydroquinone) to TriCH (trichloro-p-hydroqui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84470a5fc1882f48f7391c9abaa56545
https://pubmed.ncbi.nlm.nih.gov/20388120

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