Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Randy W. Lesh"'
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Akademický článek
Prevalence of pathogenic variants in DNA damage response and repair genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer
Autor: Tiffiney R. Hartman, Elena V. Demidova, Randy W. Lesh, Lily Hoang, Marcy Richardson, Andrea Forman, Lisa Kessler, Virginia Speare, Erica A. Golemis, Michael J. Hall, Mary B. Daly, Sanjeevani Arora
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Pathogenic variants (PVs) in multiple genes are known to increase the risk of early-onset renal cancer (eoRC). However, many eoRC patients lack PVs in RC-specific genes; thus, their genetic risk remains undefined. Here, we determine if PVs i
Externí odkaz: https://doaj.org/article/2fc011ae6b1b4fdcabeb4fe468c8545c
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2
Therapeutic implications of germline vulnerabilities in DNA repair for precision oncology
Autor: Shreya M. Shah, Elena V. Demidova, Randy W. Lesh, Michael J. Hall, Mary B. Daly, Joshua E. Meyer, Martin J. Edelman, Sanjeevani Arora
Publikováno v: Cancer Treat Rev
DNA repair vulnerabilities are present in a significant proportion of cancers. Specifically, germline alterations in DNA repair not only increase cancer risk but are associated with treatment response and clinical outcomes. The therapeutic landscape
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac17b46c1fe644f37a1abd2db7c3126
https://europepmc.org/articles/PMC9016579/
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3
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors
Autor: Martin J. Edelman, Michal Kubiak, Yanis Boumber, Hossein Borghaei, Usman Ali, Rodion Velichinskii, Sanjeevani Arora, Randy W. Lesh, Pranshu Bansal
Publikováno v: Advances in Therapy
In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b2a8eb65a8fe41304526cd17befcf5
https://doi.org/10.1007/s12325-019-01051-z
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4
Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer
Autor: Tiffiney R. Hartman, Marcy E. Richardson, Sanjeevani Arora, Virginia Speare, Mary B. Daly, Lily Hoang, Elena Demidova, Andrea Forman, Randy W. Lesh, Lisa Kessler, Michael J. Hall, Erica A. Golemis
PurposePathogenic variants (PVs) in a number of genes are known to increase the risk of hereditary renal cancer (hRC). However, many early-onset RC (eoRC) patients undergoing genetic testing lack PVs in hRC genes; thus, their genetic risk remains und
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f53f2ac0a13a3abd116be2f308a7f55
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5
Abstract 349: Association of DNA damage response capacity with neoadjuvant chemoradiation response in locally advanced rectal cancer
Autor: Joshua E. Meyer, Margret B. Einarson, V. Avkshtol, Sanjeevani Arora, Randy W. Lesh, Erica A. Golemis, Elena Demidova
Publikováno v: Cancer Research. 81:349-349
Background: Locally advanced rectal cancer (RC) cases are ~60% of newly diagnosed RCs, with neoadjuvant chemoradiation therapy (nCRT) followed by surgery as the standard of care. While nCRT is highly toxic, it is also beneficial. Recent prospective t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d153b84906ef839d7f0940695a1233
https://doi.org/10.1158/1538-7445.am2021-349
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Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods
Autor: Rahmat K. Sikder, Randy W. Lesh, Peter J. Huwe, Sanjeevani Arora, Sanat Deshpande, Michael J. Hall, Amanda J. Browne, Erica A. Golemis, Roland L. Dunbrack, Manali Shah, Emmanuelle Nicolas
Publikováno v: Cancer Biology & Therapy. 18:519-533
The cancer-predisposing Lynch Syndrome (LS) arises from germline mutations in DNA mismatch repair (MMR) genes, predominantly MLH1, MSH2, MSH6, and PMS2. A major challenge for clinical diagnosis of LS is the frequent identification of variants of unce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a5d186fcbecf69de4498ff13d75715
https://doi.org/10.1080/15384047.2017.1326439
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