Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Randy W. Hyppa"'
Publikováno v:
Nucleic Acids Research
During meiosis, DNA double-strand breaks (DSBs) are formed at high frequency at special chromosomal sites, called DSB hotspots, to generate crossovers that aid proper chromosome segregation. Multiple chromosomal features affect hotspot formation. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ce9909bee7a66c0691c5af2e2e998a
http://europepmc.org/articles/PMC8789058
http://europepmc.org/articles/PMC8789058
Autor:
Silvia Polakova, Lucia Molnarova, Randy W Hyppa, Zsigmond Benko, Ivana Misova, Alexander Schleiffer, Gerald R Smith, Juraj Gregan
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006102 (2016)
To identify new proteins required for faithful meiotic chromosome segregation, we screened a Schizosaccharomyces pombe deletion mutant library and found that deletion of the dbl2 gene led to missegregation of chromosomes during meiosis. Analyses of b
Externí odkaz:
https://doaj.org/article/e82663668f1542be9e4c8fb247dd9c79
Autor:
Naina Phadnis, Lubos Cipak, Silvia Polakova, Randy W Hyppa, Ingrid Cipakova, Dorothea Anrather, Lucia Karvaiova, Karl Mechtler, Gerald R Smith, Juraj Gregan
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005225 (2015)
Proper meiotic chromosome segregation, essential for sexual reproduction, requires timely formation and removal of sister chromatid cohesion and crossing-over between homologs. Early in meiosis cohesins hold sisters together and also promote formatio
Externí odkaz:
https://doaj.org/article/95ccefd9ba9d42a6b5df24c809ffca6a
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000267 (2008)
The fission yeast Schizosaccharomyces pombe Rec12 protein, the homolog of Spo11 in other organisms, initiates meiotic recombination by creating DNA double-strand breaks (DSBs) and becoming covalently linked to the DNA ends of the break. This protein-
Externí odkaz:
https://doaj.org/article/8032bf3170014cfa82829f1190e08277
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e141 (2007)
Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends. Like recombination events, DSBs occur at hotspots in the genome, but the genetic factors re
Externí odkaz:
https://doaj.org/article/b49598dd440744499602cd1523a1bde3
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Viable gamete formation requires segregation of homologous chromosomes connected, in most species, by cross-overs. DNA double-strand break (DSB) formation and the resulting cross-overs are regulated at multiple levels to prevent overabundance along c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3fb37441434fef67925b5e01659e89
https://doi.org/10.1073/pnas.1801920115
https://doi.org/10.1073/pnas.1801920115
Publikováno v:
Methods in Molecular Biology ISBN: 9781493963386
The fission yeast Schizosaccharomyces pombe is especially well suited for studying meiosis in molecular detail. Experiments with S. pombe strains that undergo a nearly synchronous meiosis—at variable temperatures—have elucidated the mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82db04dad40a92045207e8135273fc8
https://europepmc.org/articles/PMC5771505/
https://europepmc.org/articles/PMC5771505/
Publikováno v:
Nature Protocols. 9:223-231
Synchronous cultures are often indispensable for studying meiosis. Here we present an optimized protocol for induction of synchronous meiosis in the fission yeast Schizosaccharomyces pombe. Chemical inactivation of an ATP analog-sensitive form of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238a03330e72ab98311aa3796804623f
https://doi.org/10.1038/nprot.2014.013
https://doi.org/10.1038/nprot.2014.013
Publikováno v:
Genetics. 167:593-605
During meiosis DNA double-strand breaks initiate recombination in the distantly related budding and fission yeasts and perhaps in most eukaryotes. Repair of broken meiotic DNA is essential for formation of viable gametes. We report here distinct but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd3b5a33fc76102e5a535a791fffff6
https://doi.org/10.1534/genetics.103.023762
https://doi.org/10.1534/genetics.103.023762
Publikováno v:
Cell Cycle
To study meiosis, synchronous cultures are often indispensable, especially for physical analyses of DNA and proteins. A temperature-sensitive allele of the Pat1 protein kinase (pat1-114) has been widely used to induce synchronous meiosis in the fissi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be71f7171936ecfd552ed3f234db6ae
https://pubmed.ncbi.nlm.nih.gov/22580457
https://pubmed.ncbi.nlm.nih.gov/22580457