Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Randy T. McConnell"'
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Methods and Figure Legends 1-2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a3405f44d49aec54206ba52ba0d265
https://doi.org/10.1158/0008-5472.22370963
https://doi.org/10.1158/0008-5472.22370963
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e3e38118b83488267a117b29c53cd
https://doi.org/10.1158/0008-5472.22370966
https://doi.org/10.1158/0008-5472.22370966
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 1 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4abec9d184e4e3594165c4dd227e1f2
https://doi.org/10.1158/0008-5472.22370972.v1
https://doi.org/10.1158/0008-5472.22370972.v1
Autor:
Victoria B. Knick, Tona M. Gilmer, Daniel F. Hassler, Masaaki Furuta, Randy T. McConnell, Glenn M. Spehar, Nobuhiro Noro, Kyle A. Emmitte, Robert A. Mook, Timothy J. Lansing, Mui Cheung, Derek R. Duckett
Publikováno v:
Molecular Cancer Therapeutics. 6:450-459
Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and cytokinesis. PLK1 expression and activity are strongly linked to proliferating cells. Many stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6dc37d8e317417670e30adbaf5906a
https://doi.org/10.1158/1535-7163.mct-06-0543
https://doi.org/10.1158/1535-7163.mct-06-0543
Autor:
Anthony E. Choudhry, Igor G. Safonov, Dirk A. Heerding, Jack D. Leber, Nelson Rhodes, Susan L. Strum, Mei Li, Michael D. Schaber, Peter J. Tummino, Derek J. Eberwein, Victoria B. Knick, Louis V. LaFrance, Robert A. Copeland, Timothy J. Lansing, Derek R. Duckett, Edgar R. Wood, Richard M. Keenan, Gregory L. Warren, Zhihong Lai, Joseph W. Venslavsky, Randy T. McConnell, Dennis S. Yamashita, Dennis T. Takata, Nestor O. Concha, Rakesh Kumar, Elisabeth A. Minthorn, Tammy J. Clark, Shu-Yun Zhang
Publikováno v:
Journal of medicinal chemistry. 51(18)
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22722cf2546163a2efc390d4dfb029c
https://pubmed.ncbi.nlm.nih.gov/18800763
https://pubmed.ncbi.nlm.nih.gov/18800763
Autor:
David Barrett, Daniel F. Hassler, Walter S. Dallas, Michael Cory, Kurt Weaver, Randy T. McConnell, Kevin Blackburn, Gary K. Smith, Roderick G. Davis, Mary B. Moyer
Publikováno v:
Archives of biochemistry and biophysics. 399(2)
Because of the intimate role of caspase-8 in apoptosis signaling pathways from FAS, TNFR1, and other death receptors, the enzyme is a potentially important therapeutic target. We have generated an Escherichia coli expression construct for caspase-8 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b890271ba42f6de76a84b71cab0af5a7
https://pubmed.ncbi.nlm.nih.gov/11888206
https://pubmed.ncbi.nlm.nih.gov/11888206
Autor:
Diane M. Otterness, Randy T. McConnell, L.H. Zalkow, H. L. Carter, Wenge Xie, Robert T. Abraham, H. Peng, Garth Powis, J. P. Cogswell
Publikováno v:
Journal of medicinal chemistry. 44(5)
Silica gel supported pyrolysis of an azido-homo-oxa steroid led to rearrangement, presumably by a mechanism similar to that of solution phase Schmidt fragmentation, to produce a group of novel inhibitors for the oncogenic cell cycle regulator Cdc25A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4ada2db8a21785459fc07e29e2f60d
https://pubmed.ncbi.nlm.nih.gov/11262093
https://pubmed.ncbi.nlm.nih.gov/11262093
Publikováno v:
The International journal of biochemistry. 23(3)
1. 1. Membrane association of protein kinase C is thought to be a prerequisite for the activation of the enzyme. 2. 2. We studied the association of the enzyme with liposome. 3. 3. We show here that the mechanisms for the calcium- and the phorbol est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d5d8358a15795d3982af1298290031
https://pubmed.ncbi.nlm.nih.gov/2044837
https://pubmed.ncbi.nlm.nih.gov/2044837
Publikováno v:
Prostaglandins. 21:123-132
Rat neutrophils isolated from three-hour carrageenan pleural exudates actively metabolize arachidonic acid into three major metabolites, HHT, 11-HETE and 15-HETE. However, in the presence of the calcium ionophore, A23187, or the non-ionic detergent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fed21caec85341462e65018cb8567e4
https://doi.org/10.1016/0090-6980(81)90202-1
https://doi.org/10.1016/0090-6980(81)90202-1
Publikováno v:
Biochemistry. 20:5297-5301
The human promyelocytic leukemia cell line HL60 can be induced to differentiate into mature granulocytes by exposure to Me2SO. [1-14C]Arachidonic acid incubated overnight with these cells was incorporated mainly into membrane phospholipids. Stimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a4fb12b6776c605c0ab79ac2e6ac3d
https://doi.org/10.1021/bi00521a032
https://doi.org/10.1021/bi00521a032