Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Randy Shen"'
Autor:
Hal E. Broxmeyer, Randy Shen, Tetsuzo Tauchi, Mark S. Marshall, Charlie Mantel, Gen-Sheng Feng, Tony Pawson
Publikováno v:
Journal of Biological Chemistry. 269:25206-25211
The c-kit proto-oncogene encodes a transmembrane tyrosine kinase receptor, which is important for the normal development of hematopoietic cells, melanoblasts, and germ cells. Autophosphorylation of c-kit receptor on tyrosine creates binding sites for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb08c89b9394928756aab3b2ae7d91ca
https://doi.org/10.1016/s0021-9258(17)31518-1
https://doi.org/10.1016/s0021-9258(17)31518-1
Autor:
Ho Yeong Song, Tony Pawson, Gen-Sheng Feng, Hal E. Broxmeyer, Tetsuzo Tauchi, Randy Shen, David B. Donner
Publikováno v:
Journal of Biological Chemistry. 269:15381-15387
The phosphorylation of proteins at tyrosine residues is critical in cellular signal transduction and neoplastic transformation. These mechanisms are regulated by the activities of both protein-tyrosine kinases and protein-tyrosine phosphatases. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26aeda323731eda71124edc355cd6da
https://doi.org/10.1016/s0021-9258(17)36617-6
https://doi.org/10.1016/s0021-9258(17)36617-6
Autor:
Randy Shen, Marc-André Lachance
Publikováno v:
Yeast. 9:315-330
The rDNAs of strains of the cactophilic Pichia species P. amethionina, P. antillensis, P. barkeri, P. cactophila, P. caribaea, P. deserticola, P. heedii, P. kluyveri, P. norvegenesis, P. opuntiae, P. pseudocactophila, P. thermotolerans and their vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be79b2a95312c38ed3215979b87b6422
https://doi.org/10.1002/yea.320090402
https://doi.org/10.1002/yea.320090402
Autor:
Randy Shen, Mark H. Kaplan
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 169(2)
The cyclin-dependent kinase inhibitor p27Kip1 is a critical regulator of T cell proliferation. To further examine the relationship of T cell proliferation and differentiation, we examined the ability of T cells deficient in p27Kip1 to differentiate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edfa58d83acfe584a284f2ba0aa3de0
https://pubmed.ncbi.nlm.nih.gov/12097373
https://pubmed.ncbi.nlm.nih.gov/12097373
Autor:
Ying Bin Ouyang, Randy Shen, Andres Alonso, Mark H. Kaplan, Tomas Mustelin, Gen-Sheng Feng, Lindsey Sperzel, Cheng Kui Qu
Publikováno v:
Molecular and cellular biology. 22(10)
Antigen stimulation of the T-cell receptor (TCR) elicits multiple intracellular signaling pathways that culminate in the upregulation of transcription of specific genes, leading to lymphocyte activation and proliferation (9). Among the earliest event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ed353d5a8b6fc6e55769f7cf57f23d
https://pubmed.ncbi.nlm.nih.gov/11971956
https://pubmed.ncbi.nlm.nih.gov/11971956
Autor:
Keith Burridge, Randy Shen, Simone M. Schoenwaelder, David Williamson, Leslie Petch, Gen-Sheng Feng
Publikováno v:
Current biology : CB. 10(23)
Remodeling of filamentous actin into distinct arrangements is precisely controlled by members of the Rho family of small GTPases [1]. A well characterized member of this family is RhoA, whose activation results in reorganization of the cytoskeleton i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f321910a84b63ab7a23bcf2624f3424
https://pubmed.ncbi.nlm.nih.gov/11114521
https://pubmed.ncbi.nlm.nih.gov/11114521
Publikováno v:
The Journal of biological chemistry. 274(28)
We describe a novel human adapter molecule containing a pleckstrin homolgy (PH) domain at the N terminus that is closely related to human Grb2-associated binder 1, Gab1, and Drosophila daughter of sevenless. We designate this protein as Gab2. Norther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1ae663045f45a2367c2d4923d503f7
https://pubmed.ncbi.nlm.nih.gov/10391903
https://pubmed.ncbi.nlm.nih.gov/10391903
Publikováno v:
Molecular and cellular biology. 17(9)
Shp-1 and Shp-2 are cytoplasmic protein tyrosine phosphatases that contain two Src homology 2 (SH2) domains. A negative regulatory role of Shp-1 in hematopoiesis has been strongly implicated by the phenotype of motheaten mice with a mutation in the S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8a749f77d9c01857a220ae72195409
https://pubmed.ncbi.nlm.nih.gov/9271425
https://pubmed.ncbi.nlm.nih.gov/9271425
Autor:
Randy Shen, Gen-Sheng Feng, Tracy M. Saxton, Tony Pawson, Mark Henkemeyer, Derrick J. Rossi, Stéphan Gasca, Fouad Shalaby
Publikováno v:
The EMBO journal. 16(9)
Shp‐1, Shp‐2 and corkscrew comprise a small family of cytoplasmic tyrosine phosphatases that possess two tandem SH2 domains. To investigate the biological functions of Shp‐2, a targeted mutation has been introduced into the murine Shp‐2 gene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef82db8f6ac63508f32983b685dd4fd
https://pubmed.ncbi.nlm.nih.gov/9171349
https://pubmed.ncbi.nlm.nih.gov/9171349
Publikováno v:
The Journal of biological chemistry. 272(2)
Interactions between SHP-2 phosphotyrosine phosphatase and JAK tyrosine kinases have recently been implicated in cytokine signal transduction. However, the molecular basis of these interactions is not well understood. In this study, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3758f8279704ed3175a4d7c54fcd6da
https://pubmed.ncbi.nlm.nih.gov/8995399
https://pubmed.ncbi.nlm.nih.gov/8995399