Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Randy S. Wymore"'
Autor:
Michel Lazdunski, John P. Adelman, Gary V. Desir, Jonathan Robbins, Stephan Grissmer, Heike Wulff, Gail A. Robertson, Manuel Covarriubias, Douglas A. Bayliss, David McKinnon, Bernardo Rudy, Henry A. Lester, Andreas Karschin, Aguan Wei, David E. Clapham, Kiyoshi Furuichi, Maria L. Garcia, Randy S. Wymore, Barry Ganetzky, K. George Chandy, Michael C. Sanguinetti, Lily Yeh Jan, Jayashree Aiyar, Yoshihisa Kurachi, Walter Stuehmer, Florian Lesage, Colin G. Nichols, Ita O'Kelly, Sabina Kuperschmidt, Michael M. Tamkun, George A. Gutman, Susumu Seino, Carol A. Vandenberg, Donghee Kim
Publikováno v:
Pharmacological Reviews. 55:575-578
This summary article presents an overview of the molecular relationships among the voltage-gated sodium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80d8a785235d7399f1aae9d8a3658d0
https://doi.org/10.1124/pr.55.4.7
https://doi.org/10.1124/pr.55.4.7
Publikováno v:
Journal of Membrane Biology. 178:89-101
Epithelial cells from the anterior and equatorial surfaces of the frog lens were isolated and used the same day for studies of the Na/K ATPase. RNase protection assays showed that all cells express α1- and α2-isoforms of the Na/K pump but not the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bad9a8b7ea9ef8595a60f234f31f7e
https://doi.org/10.1007/s002320010017
https://doi.org/10.1007/s002320010017
Autor:
Randy S. Wymore, Wenmei Shi, David McKinnon, Barry S. Brown, Hong-Sheng Wang, Zongming Pan, Jane E. Dixon, Ira S. Cohen
Publikováno v:
Science. 282:1890-1893
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010cac7254d3cbf5c3dce640c20f3f69
https://doi.org/10.1126/science.282.5395.1890
https://doi.org/10.1126/science.282.5395.1890
Publikováno v:
Circulation Research. 80:261-268
The human K + channel gene, HERG, has been linked to the type 2 form of the autosomal dominant long-QT syndrome and has been suggested to encode the fast component of the delayed rectifier K + current (I Kr ) found in heart. To date, the published el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79369921ea2aaf5d41ee065fc73a31c0
https://doi.org/10.1161/01.res.80.2.261
https://doi.org/10.1161/01.res.80.2.261
Autor:
K. Kalman, Jayashree Aiyar, Deborah Negulescu, George A. Gutman, Randy S. Wymore, K. George Chandy, Keith D. Kinoshita
Publikováno v:
Journal of Biological Chemistry. 271:15629-15634
The mouse voltage-gated K+ channel gene, Kv1.4, is expressed in brain and heart as approximately 4.5- and approximately 3.5-kilobase (kb) transcripts. Both mRNAs begin at a common site 1338 bp upstream of the initiation codon, contain 3477 and 4411 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a621de6290fb6022761aa780abd6312
https://doi.org/10.1074/jbc.271.26.15629
https://doi.org/10.1074/jbc.271.26.15629
Autor:
Nancy A. Jenkins, George A. Gutman, Julie R. Korenberg, Christopher Coyne, K. George Chandy, Carolyn M. Hustad, Randy S. Wymore, Xiao Ning Chen, Neal G. Copeland, Jayashree Aiyar, Keith D. Kinoshita
Publikováno v:
Genomics. 20:191-202
A genomic clone encoding the Shaker-related potassium channel gene, Kcna4/mKv1.4, was isolated from mice. Its coding region is contained in a single exon, encodes a protein of 654 amino acids, and shares approximately 91% nucleotide sequence identity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48963fcb57be598320ba0c1d77ff57a6
https://doi.org/10.1006/geno.1994.1153
https://doi.org/10.1006/geno.1994.1153
Autor:
Olivia Crociani, Marika Masselli, Elisa Redaelli, Tommaso Mello, Amedeo Amedei, Annarosa Arcangeli, Leonardo Guasti, Enzo Wanke, Andrea Galli, Simone Polvani, Serena Pillozzi, Randy S. Wymore
A common feature of tumor cells is the aberrant expression of ion channels on their plasma membrane. The molecular mechanisms regulating ion channel expression in cancer cells are still poorly known. K+ channels that belong to the human ether-a-go-go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4b8a49197e5b4be79e44c7ceed01e
https://europepmc.org/articles/PMC2519704/
https://europepmc.org/articles/PMC2519704/
Autor:
Gary V. Desir, I. T. A. O'kelly, David McKinnon, Kiyoshi Furuichi, Maria L. Garcia, Bernardo Rudy, Jonathan Robbins, Lily Yeh Jan, John P. Adelman, Jayashree Aiyar, David E. Clapham, Florian Lesage, Michel Lazdunski, Stephan Grissmer, Manuel Covarriubias, Randy S. Wymore, Heike Wulff, Gail A. Robertson, George A. Gutman, Michael C. Sanguinetti, Aguan Wei, Carol A. Vandenberg, Susumu Seino, Douglas A. Bayliss, Sabina Kuperschmidt, Michael M. Tamkun, Colin G. Nichols, Henry A. Lester, Walter Stuehmer, Barry Ganetzky, K. George Chandy, Yoshihisa Kurachi, Donghee Kim, Andreas Karschin
Publikováno v:
Pharmacological reviews. 55(4)
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels.1 The complete Compend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcda5cc931df2576178ccd1d7586530b
https://pubmed.ncbi.nlm.nih.gov/14657415
https://pubmed.ncbi.nlm.nih.gov/14657415
Autor:
Olivia Crociani, Andrea Becchetti, Annarosa Arcangeli, Enzo Wanke, Randy S. Wymore, Massimo Olivotto, Manuela Balzi, Leonardo Guasti
The role of K(+) channel activity during cell cycle progression has become a research topic of considerable interest. Blocking of K(+) channels inhibits the proliferation of many cell types, although the mechanism of this inhibition is unclear. There
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aba8bc6d1742f0e05c2dfece6eaa43
http://hdl.handle.net/10281/54397
http://hdl.handle.net/10281/54397
Autor:
B. Holmes, Hong-Zhan Wang, David McKinnon, Jane E. Dixon, Joan Zuckerman, William B. Benjamin, Hangang Yu, Rigel T. Wymore, Randy S. Wymore, Ira S. Cohen, M. R. El-Maghrabi, Richard B. Robinson, Wenmei Shi, Irina A. Potapova, Zongming Pan, Jiying Wu
Publikováno v:
Circulation research. 88(12)
Abstract —The HCN family of ion channel subunits underlies the currents I f in heart and I h and I q in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family. As such, it enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8ec55c69241f116f29a55686b9071c
https://pubmed.ncbi.nlm.nih.gov/11420311
https://pubmed.ncbi.nlm.nih.gov/11420311